公开(公告)号：US20070134234A1

公开(公告)日：2007-06-14

申请号：US11541449

申请日：2006-09-29

申请人： Craig Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

发明人： Craig Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K16/46 ,  C12N5/06 ,  C12P21/08

CPC分类号： C12N9/16 ,  A61K38/162 ,  C07K14/005 ,  C07K14/70539 ,  C07K16/2803 ,  C07K2319/30 ,  C12N2710/24022 ,  C12N2710/24122

摘要： The poxvirus proteins designated A41L and 130L bind to three receptor-like protein tyrosine phosphatases (RPTP), leukocyte common antigen related protein (LAR), RPTP-δ, and RPTP-σ, that are present on the cell surface of immune cells. When a host is infected with the poxvirus, binding of A41L to cell surface proteins on the host cells results in suppression of the immune response. The present invention provides agents such as antibodies, and antigen-binding fragments thereof, small molecules, aptamers, small interfering RNAs, and peptide-IgFc fusion polypeptides that interact with one or more of LAR, RPTP-δ, and RPTP-σ expressed by immune cells or interact with a polynucleotide encoding the RPTP. Also provided are RPTP Ig domain oligomers and Fc fusion polypeptides. Such agents are useful for treating an immunological disorder in a subject according to the methods described herein.

摘要翻译： 命名为A41L和130L的痘病毒蛋白与存在于免疫细胞的细胞表面上的三种受体样蛋白酪氨酸磷酸酶（RPTP），白细胞常见抗原相关蛋白（LAR），RPTP-delta和RPTP-sigma结合。 当宿主感染痘病毒时，A41L与宿主细胞上的细胞表面蛋白的结合导致免疫应答的抑制。 本发明提供诸如抗体及其抗原结合片段，小分子，适体，小干扰RNA和肽-IgFc融合多肽的试剂，其与LAR，RPTP-δ和RPTP-sigma中的一种或多种相互作用， 免疫细胞或与编码RPTP的多核苷酸相互作用。 还提供了RPTP Ig结构域寡聚体和Fc融合多肽。 根据本文所述的方法，这样的试剂可用于治疗受试者的免疫学障碍。

公开(公告)号：US20070264654A1

公开(公告)日：2007-11-15

申请号：US11728329

申请日：2007-03-22

申请人： Steven Wiley ,  Craig Smith ,  Ajamete Kaykas

发明人： Steven Wiley ,  Craig Smith ,  Ajamete Kaykas

IPC分类号： G01N33/53 ,  C12Q1/68

CPC分类号： G01N33/6845 ,  A61K39/3955 ,  C12Q1/18 ,  C12Q1/70 ,  G01N33/5008 ,  G01N33/56983 ,  G01N2500/02

摘要： The present invention provides methods for identifying viral virulence factors and for identifying cellular polypeptides to which the viral polypeptides bind. The cellular polypeptide is useful as a therapeutic target or as a therapeutic agent for treating diseases and disorders, including immunological diseases or disorders.

摘要翻译： 本发明提供用于鉴定病毒毒力因子和鉴定病毒多肽结合的细胞多肽的方法。 细胞多肽可用作治疗靶点或用作治疗疾病和病症（包括免疫疾病或病症）的治疗剂。

公开(公告)号：US07874606B2

公开(公告)日：2011-01-25

申请号：US12361611

申请日：2009-01-29

申请人： Takashi Yamamura ,  Craig Smith

发明人： Takashi Yamamura ,  Craig Smith

IPC分类号： B60N2/36

CPC分类号： B62D21/08 ,  B60N2/3011 ,  B60N2/305 ,  B60N2/686 ,  B60R22/023 ,  B60R22/24 ,  B60R2022/1818 ,  B62D25/087 ,  B62D33/02 ,  B62D33/0625

摘要： A utility vehicle includes a vehicle body frame, a pair of left and right front wheels and at least a pair of left and right rear wheels that are supported on the vehicle frame, a front seat that is provided to the rear of the front wheels, and a rear seat that is provided to the rear of the front seat and including an in-use position, a transition position, and a non-use position. A cargo bed, disposed to the rear of the front seat includes a bottom wall portion whereon the seat cushion portion of the rear seat is provided movably; a left side wall portion and a right side wall portion that are provided on the left and right side portions of the bottom wall portion, wherein the left side wall portion and the right side wall portion extend forward to the rear seat in its non-use position; and a rear wall portion that is provided at the rear end portion of the bottom wall portion. The utility vehicle further includes a rear floor provided between the front seat and the rear seat and lower than the bottom wall portion of the cargo bed.

摘要翻译： 一种多功能车辆包括车身框架，一对左前轮和右前轮以及支撑在车架上的至少一对左右后轮，设置在前轮后部的前排座椅， 以及后座，其设置在所述前座的后部并且包括使用中的位置，过渡位置和不使用位置。 设置在前排座椅后部的货床包括底壁部分，其后座的座垫部分可移动地设置; 左侧壁部分和右侧壁部分，其设置在底壁部分的左侧和右侧部分上，其中左侧壁部分和右侧壁部分在其不使用中向前延伸到后座椅 位置; 以及设置在所述底壁部的后端部的后壁部。 多功能车还包括设置在前排座椅和后座椅之间并且低于货物底板的底壁部分的后底板。

公开(公告)号：US07735903B2

公开(公告)日：2010-06-15

申请号：US12361605

申请日：2009-01-29

申请人： Takashi Yamamura ,  Craig Smith

发明人： Takashi Yamamura ,  Craig Smith

IPC分类号： B60N3/00 ,  B62D25/00

CPC分类号： B62D23/005 ,  B60N2/005 ,  B60N2/06 ,  B60N2/3011 ,  B60N2/305 ,  B60N2/686 ,  B60N2/803 ,  B62D25/04

摘要： A utility vehicle includes a vehicle body frame having a left side portion and a right side portion, a front seat affixed to the vehicle body frame, a rear seat affixed to the vehicle body frame provided to the rear of the front seat, and a rear floor affixed to the vehicle body frame provided between the front seat and the rear seat. A first roof support structure includes a first left pipe member and first right pipe member that extend generally in the vertical direction from the vehicle body frame, a second roof support structure includes a second left pipe member and a second right pipe member that extend generally in the vertical direction from the vehicle body frame, and a third roof support structure includes a third left pipe member and third right pipe member that extend generally in the vertical direction from the vehicle body frame.

摘要翻译： 一种多功能车辆包括具有左侧部分和右侧部分的车体框架，固定到车身框架上的前座椅，固定到设置在前座椅后部的车体框架的后座椅，以及后座椅 底板固定在设置在前排座椅和后座椅之间的车体框架上。 第一屋顶支撑结构包括从车身框架大致沿垂直方向延伸的第一左管构件和第一右管构件，第二屋顶支撑结构包括第二左管构件和第二右管构件，第二右管构件大体上延伸 来自车体框架的垂直方向和第三车顶支撑结构包括从车体框架大致沿垂直方向延伸的第三左管件和第三右管件。

公开(公告)号：US07728539B2

公开(公告)日：2010-06-01

申请号：US11750839

申请日：2007-05-18

申请人： Craig Smith ,  Stan Shepherd ,  Xin Yang ,  Yu Sun

发明人： Craig Smith ,  Stan Shepherd ,  Xin Yang ,  Yu Sun

IPC分类号： H02P6/18

CPC分类号： G11B5/5526 ,  G11B5/59633 ,  G11B5/59666

摘要： Devices and methods for performing dynamic sampling of a back electromotive force (BEMF) measurement are provided. A device has hardware, including a voice coil motor (VCM) for receiving a VCM command signal and a correction circuit, for obtaining the VCM command signal and a coil voltage measurement from the hardware, where the correction circuit removes a transient voltage measurement due to a change in the VCM command signal from the coil voltage measurement and outputs an estimated BEMF measurement.

摘要翻译： 提供了用于执行反电动势（BEMF）测量的动态采样的装置和方法。 一种设备具有硬件，包括用于接收VCM命令信号的音圈电机（VCM）和用于从硬件获得VCM命令信号和线圈电压测量的校正电路，其中校正电路去除由于 来自线圈电压测量的VCM命令信号的变化并输出估计的BEMF测量值。

公开(公告)号：US20090183938A1

公开(公告)日：2009-07-23

申请号：US12355854

申请日：2009-01-19

申请人： Steven Cover ,  Craig Smith ,  Satoshi Kubota

发明人： Steven Cover ,  Craig Smith ,  Satoshi Kubota

IPC分类号： B60K5/00 ,  B62D25/00

CPC分类号： B60N2/305 ,  B60N2/005 ,  B60N2/01508 ,  B60N2/06 ,  B60N2/0825 ,  B60N2/085 ,  B60N2/0887 ,  B60N2/3011 ,  B60N2/686 ,  B60N2/803

摘要： A vehicle having a center console 29 provided with left and right walls 29a and 29b, and a top wall 29c, provided to the rear, in the front/back direction of the vehicle, from a front panel 5, extending rearward, in the front/back direction of the vehicle, from the center portion, in the direction of width of the vehicle, of the front panel 5 to at least the front end of a seat 7, wherein the top wall 29c is provided at a position that is higher than the bottommost end a of the front portion of a seating surface 7e of a seat cushion portion 7a of the front seat 7 and higher than the top end of an engine 6, and at a position that is lower than a top end 5b of the front panel 5.

摘要翻译： 具有设置有左右壁29a和29b的中心控制台29的车辆和从车辆的前后方向设置在车辆的前后方向上的前壁板5c的前壁5 /后方向，从前面板5的车辆宽度方向的中央部至少到座椅7的前端，其中，顶壁29c设置在较高的位置 比前座椅7的座垫部7a的座部表面7e的前部的最底端部a高于发动机6的顶端，并且位于低于发动机6的顶端5b的位置 前面板5。

公开(公告)号：US07331308B1

公开(公告)日：2008-02-19

申请号：US11120754

申请日：2005-05-02

申请人： Craig Smith

发明人： Craig Smith

IPC分类号： A01K5/00

CPC分类号： A01K5/0225

摘要： An exemplary collapsible game feeder and method are provided. In one embodiment, the collapsible game feeder includes a collapsible container and a dispensing device. The collapsible container may receive and store feed and release feed to the dispensing device for dispensing external the collapsible game feeder. In another aspect of the invention, a method for transporting and using a collapsible game feeder. The method includes providing a collapsible game feeder, transporting the collapsible game feeder to a desired location in the collapsed state, filling the collapsible game feeder with feed, and using the collapsible game feeder by having it dispense feed. The present invention also encompasses other embodiments and methods.

摘要翻译： 提供了一种示例性的可折叠游戏进给器和方法。 在一个实施例中，可折叠游戏进给器包括可折叠容器和分配装置。 可折叠容器可以接收和存储进给和释放进料到分配装置以分配外部可折叠游戏进料器。 在本发明的另一方面，一种用于运送和使用可折叠游戏进给器的方法。 该方法包括提供可折叠游戏进给器，将可折叠游戏进给器运送到折叠状态的期望位置，用可进给的饲料填充可折叠游戏进给器，并通过使其可分配饲料使用可折叠游戏进给器。 本发明还包括其他实施方案和方法。

公开(公告)号：US20070291401A1

公开(公告)日：2007-12-20

申请号：US11750853

申请日：2007-05-18

申请人： Yu Sun ,  Craig Smith ,  Stanley Shepherd

发明人： Yu Sun ,  Craig Smith ,  Stanley Shepherd

IPC分类号： G11B21/02 ,  G11B5/596

CPC分类号： G11B5/596 ,  G11B5/59666 ,  G11B5/6064

摘要： Embodiments of the present invention allow for detection of contact between a sensor, such as a data read/write head, and a surface, such as the magnetic surface of a disc. An actuator may be controlled to repeatedly seek a head across a surface of a disc. A touchdown actuation pattern may be provided to the head during the seeks and a set of measurements are made to detect contact.

摘要翻译： 本发明的实施例允许检测诸如数据读/写头的传感器与诸如盘的磁性表面的表面之间的接触。 可以控制致动器以重复地跨越盘的表面寻找头部。 在寻求期间可以向头部提供触地致动模式，并且进行一组测量以检测接触。

公开(公告)号：US20060240448A1

公开(公告)日：2006-10-26

申请号：US11319146

申请日：2005-12-27

申请人： Rex Bitner ,  Craig Smith ,  Douglas White ,  Braeden Butler ,  Jacqui Sankbeil

发明人： Rex Bitner ,  Craig Smith ,  Douglas White ,  Braeden Butler ,  Jacqui Sankbeil

IPC分类号： C12Q1/68 ,  C12N1/08 ,  C07H21/04

CPC分类号： C12N15/1006 ,  C12N1/02 ,  C12N15/1013 ,  C12Q1/6806 ,  Y10T436/143333

摘要： Methods are disclosed for using paramagnetic particles to concentrate or harvest cells. Methods are also disclosed for clearing a solution of disrupted biological material, such as a lysate of cells or a homogenate of mammalian tissue. Methods are also disclosed for using paramagnetic particles to isolate target nucleic acids, such as RNA or DNA, from a solution cleared of disrupted biological material using the same type or a different type of paramagnetic particle. Kits are also disclosed for use with the various methods of the present invention. Nucleic acids isolated according to the present methods and using the present kits are suitable for immediate use in downstream processing, without further purification.

摘要翻译： 公开了使用顺磁性颗粒来浓缩或收获细胞的方法。 还公开了用于清除破坏的生物材料（例如细胞裂解物或哺乳动物组织的匀浆）的溶液的方法。 还公开了使用顺磁性颗粒从使用相同类型或不同类型的顺磁性颗粒清除的破坏的生物材料的溶液中分离靶核酸（例如RNA或DNA）的方法。 还公开了用于本发明的各种方法的试剂盒。 根据本发明方法分离并使用本试剂盒的核酸适用于下游处理中即时使用，无需进一步纯化。

公开(公告)号：US20060065869A1

公开(公告)日：2006-03-30

申请号：US11127918

申请日：2005-05-12

申请人： Stephen Chipman ,  Michael Luque ,  Herman Pieterse ,  Jeffrey Robison ,  Craig Smith

发明人： Stephen Chipman ,  Michael Luque ,  Herman Pieterse ,  Jeffrey Robison ,  Craig Smith

IPC分类号： F16K47/16

CPC分类号： F16K47/16

摘要： A nozzle design and method for designing such a nozzle being adapted for three phase slurry flow from the choke into the flash tank during pressure let-down in autoclave mining operations that uses a selection of the expansion ratio in the choke to select a nozzle dispersion angle to select a spread of the flow over the slurry pool in the flash tank, to generally maximize the use of the pool for energy dissipation without causing undo wear and tear on the tank walls.

摘要翻译： 用于设计这种喷嘴的喷嘴设计和方法适用于在高压灭菌开采操作中的压力降低期间从扼流器到闪蒸罐的三相浆料流动，其使用选择扼流圈中的膨胀比来选择喷嘴分散角 选择在闪蒸罐中的浆液池中的流动的扩散，以通常最大限度地利用池的能量耗散，而不会在罐壁上造成不可磨损的磨损。