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公开(公告)号：US5885985A
公开(公告)日：1999-03-23
申请号：US525663
申请日：1995-09-21
IPC分类号： C07D205/04 , C07D207/22 , C07D217/06 , C07D233/22 , C07D295/215 , A61K31/40 , C07D401/14 , C07D403/14
CPC分类号： C07D295/215 , C07D205/04 , C07D207/22 , C07D217/06 , C07D233/22
摘要： Guanidine derivatives of formula I ##STR1## wherein R.sup.8 represents hydrogen, halogen, alkyl C1 to 6, nitro, trifluoromethyl, thioalkyl C1 to 6, hydroxy, alkoxy C1 to 6, or a group selected from --NR.sup.4 R.sup.5, --O(CH.sub.2).sub.p Q, --(CH.sub.2).sub.m OQ, --(CH.sub.2).sub.m NR.sup.1 R.sup.2, --O(CH.sub.2).sub.m NR.sup.1 R.sup.2, --NHCO(CH.sub.2).sub.m NH(CH.sub.2).sub.n Q or --(CH.sub.2).sub.p CONR.sup.1 R.sup.2, or R.sup.8 represents the group A--CO--B; R.sup.9 represents hydrogen, halogen, alkyl C1 to 6, nitro or trifluoromethyl;and R.sup.1, R.sup.2, R.sup.4, R.sup.5, n, m, p, Q, A, B, and W are as defined in the specification, are described together with processes for their manufacture and compositions containing them. Compounds of formula I are useful in therapy.
摘要翻译： PCT No.PCT / GB94 / 00584第 371 1995年9月21日第 102（e）日期1995年9月21日PCT 1994年3月22日PCT公布。 公开号WO94 / 21621 日期：1994年9月29日分子式I的胍衍生物其中R8代表氢，卤素，C1至6的烷基，硝基，三氟甲基，硫代烷基C1至6，羟基，烷氧基C1至6，或选自-NR4R5， -O（CH2）pQ， - （CH2）mOQ， - （CH2）mNR1R2，-O（CH2）mNR1R2，-NHCO（CH2）mNH（CH2）nQ或 - （CH2）pCONR1R2，或R8表示A- CO-B; R9代表氢，卤素，C1至6的烷基，硝基或三氟甲基; 并且R1，R2，R4，R5，n，m，p，Q，A，B和W如说明书中所定义，与其制备方法和含有它们的组合物一起进行了描述。 式I化合物可用于治疗。
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32.发明授权
公开(公告)号：US5844852A
公开(公告)日：1998-12-01
申请号：US907754
申请日：1997-08-08
申请人： Robert J. Murray , Paul D. Madland
发明人： Robert J. Murray , Paul D. Madland
IPC分类号： G11C7/00
CPC分类号： G11C7/12
摘要： The precharged bit lines of a memory array are provided with corresponding pass gate devices and a common complementary regulation and control circuitry to keep the precharged bit lines at a voltage below a first voltage and to counter-act any leakage to Vcc through a small current drain to a reference voltage. As a result, the voltage on the precharged bit lines are prevented from moving closer to Vcc, even during a prolonged idle period, and failure will not occur, when the memory cells are accessed again after the prolonged idle period.
摘要翻译： 存储器阵列的预充电位线设置有对应的通过栅极器件和公共互补调节和控制电路，以将预充电位线保持在低于第一电压的电压并且通过小的电流消耗来抵消对Vcc的任何泄漏 到参考电压。 结果，即使在长时间的空闲期间，预充电位线上的电压也被阻止移动到更接近Vcc，并且在延长的空闲周期之后再次访问存储单元时，不会发生故障。
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33.发明授权
公开(公告)号：US4847301A
公开(公告)日：1989-07-11
申请号：US224646
申请日：1988-07-27
申请人： Robert J. Murray
发明人： Robert J. Murray
IPC分类号： C07D213/55 , C07D213/56 , C07D213/57 , C07D295/145 , C07D295/185
CPC分类号： C07D295/185 , C07C255/00 , C07D213/55 , C07D213/56 , C07D213/57 , C07D295/145
摘要： Novel .alpha.-aryl-.alpha.-(.omega.-aminoalkyl)-.alpha.-[hydroxy(aralkyl and cycloalkyl)]acetic acid derivatives and .alpha.-aryl-.alpha.-(.omega.-aminoalkyl)-.alpha.[alkanoyloxy(aralkyl and cycloalkyl)]acetic acid derivatives, such as N,N-dimethyl-2-(hydroxyphenylmethyl)-4-dimethylamino-2-phenylbutanamide, 2-(hydroxyphenylmethyl)-5-dimethylamino-2-phenylpentanenitrile, ethyl 2-(hydroxyphenylmethyl)-5-dimethylamino-2-phenylpentanoate, and N,N-dimethyl-2[(acetyloxy)phenylmethyl]-4-dimethylamino-2-phenylbutanamide, useful in the treatment of cardiovascular disease.
摘要翻译： 新型α-芳基-α-（ω-氨基烷基）-α-[羟基（芳烷基和环烷基）]乙酸衍生物和α-芳基-α-（ω-氨基烷基）-α[烷酰氧基（芳烷基和环烷基）] - 乙酸 衍生物，如N，N-二甲基-2-（羟基苯基甲基）-4-二甲基氨基-2-苯基丁酰胺，2-（羟基苯基甲基）-5-二甲基氨基-2-苯基戊腈，2-（羟苯基甲基）-5-二甲基氨基-2 - 苯基戊酸酯和N，N-二甲基-2 [（乙酰氧基）苯基甲基] -4-二甲基氨基-2-苯基丁酰胺，可用于治疗心血管疾病。
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34.发明授权Process for preparing pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines 失效制备吡咯并[1,2-a]咪唑和咪唑并[1,2-a]吡啶的方法
公开(公告)号：US4560758A
公开(公告)日：1985-12-24
申请号：US674380
申请日：1984-11-23
IPC分类号： C07D471/04 , C07D487/04 , C07D471/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The instantly claimed invention is a process for preparing a 3-aryl or a 2,3-diaryl-2,5,6,7-tetrahydro-3H-pyrrole[1,2-a]imidazole or a 3-aryl or a 2,3-diaryl-2,3,5,6,7,8-hexa-hydroimidazo[1,2-a]pyridine which comprises (a) contacting the acid addition salt of the corresponding cyclic methylthioimine with a 2-aryl or a 2,3-diarylaziridine and (b) recovering from the resultant reaction mixture the desired compound, useful as immunomodulators.
摘要翻译： 本发明是一种制备3-芳基或2,3-二芳基-2,5,6,7-四氢-3H-吡咯并[1,2-a]咪唑或3-芳基或2 ，3-二芳基-2,3,5,6,7,8-六氢咪唑并[1,2-a]吡啶，其包括（a）使相应的环状甲硫基亚胺的酸加成盐与2-芳基或 2,3-二芳基氮丙啶和（b）从所得反应混合物中回收可用作免疫调节剂的所需化合物。
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35.发明授权Process for preparing novel 7-thioester derivatives of 3H pyrrolo [1,2-a]-imidazole and 8-thioester derivatives of imidazo [1,2-a] pyridine 失效咪唑并[1,2-a]吡啶的3H-吡咯并[1,2-a] - 咪唑和8-硫酯衍生物的新型7-硫酯衍生物的制备方法
公开(公告)号：US4551535A
公开(公告)日：1985-11-05
申请号：US675053
申请日：1984-11-26
IPC分类号： C07D471/04 , C07D487/04 , C07D247/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The instantly claimed invention is a process for preparing novel 7-thioether derivatives of 2-aryl, 3 aryl, and 2,3-diary-2,5,7,7-tetra-hydro-3H-pyrrolo [1,2-a] imidazole and 8-thio-ether derivatives of 2-aryl, 3-aryl, and 2,3-diaryl-2,3,5,7,7,8-hexahydro-imidazo [1,2-a]-pyridine which comprises (a) contacting the corresponding amidine with about one molar equivalent of R.sub.1 SSR.sub.1 in the presence of about two molar equivalents of base and at a temperature of -78.degree. C. to about 0.degree. C. (b) contacting the corresponding amidine compound with about two molar equivalents of R,SSR, in the presence of about two molar equivalents of a base and at a temperature of from about -78.degree. C. to about 23.degree. C., said compounds being useful as immunomodulators.
摘要翻译： 本发明是一种制备2-芳基，3芳基和2,3-日记-2,5,7,7-四氢-3H-吡咯并[1,2-a]的新型7-硫醚衍生物的方法 ]咪唑和2-芳基，3-芳基和2,3-二芳基-2,3,5,7,7,8-六氢 - 咪唑并[1,2-a] - 吡啶的8-硫醚衍生物，其中 包括（a）在约2摩尔当量的碱存在下，在-78℃至约0℃的温度下，使相应的脒与约1摩尔当量的R1SSR1接触。（b）使相应的脒化合物与 约2摩尔当量的R，SSR，在约2摩尔当量碱的存在下和在约-78℃至约23℃的温度下，所述化合物可用作免疫调节剂。
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公开(公告)号：US4357584A
公开(公告)日：1982-11-02
申请号：US236424
申请日：1981-02-20
CPC分类号： H03H9/643 , H03H9/14552
摘要： A surface acoustic wave bandpass filter consists of input and output interdigital transducers (IP, OP) with an interposed track changing multistrip array (MSA). A conventional broadband array (MSA) is divided into two groups of strips with respect to a center of symmetry (C) separated by different distances along the input track (T1) and the output track (T2) such that the array (MSA) suppresses a predetermined frequency. If the input and output transducers (IP, OP) both have a double electrode configuration, electrode separation .lambda.o/4, providing a fundamental passband at a corresponding frequency f.sub.o and an equal amplitude passband at the third harmonic 3f.sub.o, then a separation difference of .lambda.o/6 between the groups of the array (MSA) in the two tracks (T1, T2) can suppress the third harmonic passband in the filter output. The two groups of the multistrip array may be further sub-divided to suppress more than one frequency (FIG. 5). Also a multistrip array arranged in groups to provide a shaped bandpass response may have each group divided to suppress a selected harmonic passband of the array (FIG. 6).
摘要翻译： 表面声波带通滤波器由输入和输出叉指式换能器（IP，OP）组成，具有插入的轨道更换多段阵列（MSA）。 传统的宽带阵列（MSA）相对于沿着输入轨道（T1）和输出轨道（T2）分开不同距离的对称中心（C）分成两组条带，使得阵列（MSA）抑制 预定频率。 如果输入和输出传感器（IP，OP）都具有双电极配置，电极分离λo / 4，在相应频率fo处提供基本通带，并在三次谐波3fo处提供等幅通带，则分离差 在两个轨道（T1，T2）中阵列组（MSA）之间的λo / 6可以抑制滤波器输出中的三次谐波通带。 多组阵列的两组可进一步细分以抑制多于一个频率（图5）。 同样，分组布置以提供成形带通响应的多频阵列可以将每个组划分以抑制阵列的所选谐波通带（图6）。
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公开(公告)号：US06542006B1
公开(公告)日：2003-04-01
申请号：US09608638
申请日：2000-06-30
申请人： Milo D. Sprague , Robert J. Murray
发明人： Milo D. Sprague , Robert J. Murray
IPC分类号： H03K19096
CPC分类号： G06F9/3869 , H03K19/0966
摘要： A reset first latching mechanism comprises a pulse chopper circuit responsive to a pulsed signal to control initiation and termination of a reset pulse wherein a domino node is to be precharged in response to the reset pulse. The reset first latching mechanism also includes domino logic circuit responsive to an evaluate pulse at an input to evaluate at the domino node based on a logic function performed by the domino logic circuit. The reset pulse is timed such that the reset pulse is completed before the evaluate at the domino node occurs.
摘要翻译： 复位第一锁存机构包括响应于脉冲信号的脉冲斩波电路，以控制复位脉冲的起始和终止，其中响应于复位脉冲将对多米诺骨架节点进行预充电。 复位第一闭锁机构还包括响应于输入处的评估脉冲的多米诺逻辑电路，以基于由多米诺逻辑电路执行的逻辑功能在多米诺骨牌节点处进行评估。 复位脉冲的定时使得复位脉冲在多米诺骨牌节点发生评估之前完成。
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公开(公告)号：US5680802A
公开(公告)日：1997-10-28
申请号：US309435
申请日：1994-09-20
申请人： Robert J. Murray
发明人： Robert J. Murray
CPC分类号： B27B1/002 , B23D59/001 , B27B31/003 , B27B31/006 , Y10T83/0448 , Y10T83/2194 , Y10T83/531 , Y10T83/6635
摘要： Previous methods of bucksawing logs slow the throughput of a sawmill in that the conveyor line is stopped while a given log is bucksawed to length. The present invention provides a method for bucksawing a log which improves the throughput speed, comprising the steps of a) advancing the log endwise along an infeed conveyor; b) raising the log above the level of said infeed conveyor while advancing the log; c) measuring the advance of the log while raised; d) stopping the log at the desired length; e) sawing the log to produce a forward log segment; and f) lowering the forward log segment onto an outfeed conveyor while advancing the remaining log segments. An apparatus for carrying out the method is also disclosed.
摘要翻译： 以前的砍伐原木的方法减慢了锯木厂的生产量，因为输送线停止，而给定的对数被锯齿长。 本发明提供了一种用于锯齿的方法，其提高了生产速度，包括以下步骤：a）沿着进料输送机向前推进对数; b）在推进原木的同时将木材提升到所述进料输送机的水平面上方; c）测量升高时日志的提前; d）以所需长度停止原木; e）锯切日志以产生正向日志段; 以及f）将前进日志段降低到出料输送机上，同时推进剩余的日志段。 还公开了一种用于执行该方法的装置。
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39.发明授权Diphenyl-1-(aminoalkyl)-2-piperidinone and -2-pyrrolidinone derivatives having anticonvulsant properties 失效具有抗惊厥性质的二苯基-1-（氨基烷基）-2-哌啶酮和-2-吡咯烷酮衍生物
公开(公告)号：US5334720A
公开(公告)日：1994-08-02
申请号：US666120
申请日：1991-03-07
IPC分类号： C07D207/26 , C07D207/27 , C07D211/76 , C07D401/00
CPC分类号： C07D207/27 , C07D211/76
摘要： Compounds of the formula I, ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently represent hydrogen, alkyl, phenyl or substituted phenyl with the proviso that two of R.sub.1, R.sub.2, R.sub.3 or R.sub.4 are phenyl or substituted phenyl and two of R.sub.1, R.sub.2, R.sub.3 or R.sub.4 are hydrogen or alkyl;m represents an integer from 1-2; andn represents an integer from 1-3;or a pharmaceutically acceptable salt thereof. The compounds are useful as pharmaceuticals, in particular, in the treatment of epilepsy.
摘要翻译： 式I化合物，其中R 1，R 2，R 3和R 4独立地表示氢，烷基，苯基或取代的苯基，条件是R 1，R 2，R 3或R 4中的两个为苯基或取代的苯基， R1，R2，R3或R4是氢或烷基; m表示1-2的整数; 并且n表示1-3的整数; 或其药学上可接受的盐。 该化合物可用作药物，特别是治疗癫痫。
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40.发明授权
公开(公告)号：US5109017A
公开(公告)日：1992-04-28
申请号：US589963
申请日：1990-09-26
IPC分类号： C07D333/20
CPC分类号： C07D333/20
摘要： Compounds of the formula I, ##STR1## in which: R.sub.1 represents hydrogen or C.sub.1-6 alkyl,R.sub.2 represents hydrogen, C.sub.1-6 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl or C.sub.3-6 cycloalkyl,R.sub.3 represents one or more radicals selected from hydrogen, hydroxy, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen, trifluoromethyl, amino, lower alkylamino or dilower alkylamino,R.sub.4 represents one or more radicals selected from hydrogen or C.sub.1-6 alkyl,A represents an alpha-amino acid acyl group or an alkoxycarbonyl group,and pharmaceutically acceptable salts thereof are useful as pharmaceuticals, in particular they possess N-methyl-(d)-aspartate (NMDA) blocking properties and are useful in the treatment and/or prevention of neurological disorders such as stroke, cerebral ischaemia, cerebral palsy, hypoglycaemia, epilepsy, Alzheimer's disease, Huntington's chorea, Olivo-ponto-cerebellar atrophy, perinatal asphyxia and anoxia.
摘要翻译： 式I的化合物，其中：R1表示氢或C1-6烷基，R2表示氢，C1-6烷基，C3-6烯基，C3-6炔基或C3-6环烷基，R3代表一个或 更多的选自氢，羟基，C 1-6烷基，C 1-6烷氧基，卤素，三氟甲基，氨基，低级烷基氨基或二元烷基氨基的基团，R 4表示一个或多个选自氢或C 1-6烷基的基团，A代表α- 氨基酸酰基或烷氧基羰基及其药学上可接受的盐可用作药物，特别是它们具有N-甲基 - （ - ） - 天冬氨酸（NMDA）阻断性质，并且可用于治疗和/或预防神经障碍 如中风，脑缺血，脑性麻痹，低血糖症，癫痫，阿尔茨海默病，亨廷顿氏舞蹈病，Olivo-ponto-cerebellar萎缩，围产期窒息和缺氧。
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