Process for the preparation of lercanidipine
    31.
    发明授权
    Process for the preparation of lercanidipine 失效
    氯卡地平的制备方法

    公开(公告)号:US07772401B2

    公开(公告)日:2010-08-10

    申请号:US12603896

    申请日:2009-10-22

    CPC classification number: C07D211/90 C07D211/82

    Abstract: The invention provides a novel process for the preparation of lercanidipine or a pharmaceutical acceptable salt using novel intermediates. Thus, 2,N-dimethyl-N-(3,3-diphenylpropy1)-1-amino-2-propanol is reacted with trimethylsilyl chloride in presence of triethyl amine in methylene chloride to give 2,N-dimethyl-2-(trimethylsilyloxy)-N-(3,3-diphenylpropy1)-1-propanamine, which is then reacted with 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carbonyl chloride for 2 hours and crystallized to obtain lercanidipine hydrochloride.

    Abstract translation: 本发明提供了使用新型中间体制备氯卡地平或药学上可接受的盐的新方法。 因此,在三乙基胺的二氯甲烷存在下,使2,N-二甲基-N-(3,3-二苯基丙基)-1-氨基-2-丙醇与三甲基甲硅烷基氯反应,得到2,N-二甲基-2-(三甲基甲硅烷氧基 )-N-(3,3-二苯基丙基)-1-丙胺,然后与2,6-二甲基-5-甲氧基羰基-4-(3-硝基苯基)-1,4-二氢吡啶-3-羰基氯反应 2小时结晶,得到盐酸氯卡地平。

    ON-TARGET RAPID CONTROL PROTOTYPING
    32.
    发明申请
    ON-TARGET RAPID CONTROL PROTOTYPING 有权
    目标快速控制原型

    公开(公告)号:US20100192122A1

    公开(公告)日:2010-07-29

    申请号:US12555338

    申请日:2009-09-08

    Abstract: An on-target rapid control prototyping (RCP) system includes a host control module that generates a first RCP model based on selected function blocks in a block library. A target language compiler converts the first RCP model into source code. A cross-compiler coverts the source code into object code. A download module performs an on-target download of the object code from a host that includes the host control module to a production control module of a production system that is separate from the host.

    Abstract translation: 目标快速控制原型(RCP)系统包括主机控制模块,其基于块库中的所选功能块生成第一RCP模型。 目标语言编译器将第一个RCP模型转换为源代码。 交叉编译器将源代码覆盖为目标代码。 下载模块从包含主机控制模块的主机执行目标代码的目标下载到与主机分离的生产系统的生产控制模块。

    COALESCING AND CAPTURING DATA BETWEEN EVENTS PRIOR TO AND AFTER A TEMPORAL WINDOW
    33.
    发明申请
    COALESCING AND CAPTURING DATA BETWEEN EVENTS PRIOR TO AND AFTER A TEMPORAL WINDOW 有权
    在时间窗口之前和之后的事件之间的通话和捕获数据

    公开(公告)号:US20100169281A1

    公开(公告)日:2010-07-01

    申请号:US12344335

    申请日:2008-12-26

    CPC classification number: G06F17/30386 G06F17/30286 G06F17/30575 G06Q10/10

    Abstract: Systems and methods of coalescing and capturing data between events prior to and after a temporal window are disclosed. In an embodiment, a method includes determining a temporal window based on one or more of a user data and an automatically generated data, coalescing data between events prior to the temporal window using a processor and a physical memory and capturing data between events after the temporal window. The coalescing data between events prior to the temporal window may be determined by a set of overlapping operations to a data set, wherein certain operations have non-overlapping sectors which are not coalesced. Shifting a data view around a recovery point through a direction-agnostic roll algorithm that may use a roll-forward algorithm to shift the data view to a time after the recovery point and/or a roll-backward algorithm to shift the data view to a time before the recovery point.

    Abstract translation: 公开了在时间窗口之前和之后在事件之间聚合和捕获数据的系统和方法。 在一个实施例中,一种方法包括基于用户数据和自动生成的数据中的一个或多个来确定时间窗口,使用处理器和物理存储器在时间窗口之前的事件之间聚合数据,并且在时间之后的事件之间捕获数据 窗口。 在时间窗口之前的事件之间的合并数据可以通过对数据集合的一组重叠操作来确定,其中某些操作具有不重叠的扇区,它们不合并。 通过方向不确定的滚动算法来绕着恢复点移动数据视图,该算法可以使用前滚算法将数据视图移动到恢复点之后的时间和/或滚动后退算法以将数据视图移动到 恢复点前的时间。

    CARBON FIBERS AND FILMS AND METHODS OF MAKING SAME

    公开(公告)号:US20100112322A1

    公开(公告)日:2010-05-06

    申请号:US12525293

    申请日:2008-01-30

    CPC classification number: D01F9/225 B29C48/08 B82Y30/00 D01F1/10 Y10T428/2918

    Abstract: The various embodiments of the present invention provide improved carbon fibers and films, as well as methods of making the carbon fibers and films. The carbon fibers and films disclosed herein are generally formed from an acrylonitrile-containing polymer. The carbon fibers and/or films can also be formed from a composite that includes the acrylonitrile-containing polymer as well as carbon nanotubes, graphite sheets, or both. The fibers and films described herein can be tailored to exhibit one or more of high strength, high modulus, high electrical conductivity, high thermal conductivity, or optical transparency, depending on the desired application for the fibers or films.

    NOVEL PROCESS FOR THE PREPARATION OF LERCANIDIPINE
    35.
    发明申请
    NOVEL PROCESS FOR THE PREPARATION OF LERCANIDIPINE 失效
    制备LERCANIDIPINE的新方法

    公开(公告)号:US20100087653A1

    公开(公告)日:2010-04-08

    申请号:US12603896

    申请日:2009-10-22

    CPC classification number: C07D211/90 C07D211/82

    Abstract: The invention provides a novel process for the preparation of lercanidipine or a pharmaceutical acceptable salt using novel intermediates. Thus, 2,N-dimethyl-N-(3,3-diphenylpropy1)-1-amino-2-propanol is reacted with trimethylsilyl chloride in presence of triethyl amine in methylene chloride to give 2,N-dimethyl-2-(trimethylsilyloxy)-N-(3,3-diphenylpropy1)-1-propanamine, which is then reacted with 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carbonyl chloride for 2 hours and crystallized to obtain lercanidipine hydrochloride.

    Abstract translation: 本发明提供了使用新型中间体制备氯卡地平或药学上可接受的盐的新方法。 因此,在三乙基胺的二氯甲烷存在下,使2,N-二甲基-N-(3,3-二苯基丙基)-1-氨基-2-丙醇与三甲基甲硅烷基氯反应,得到2,N-二甲基-2-(三甲基甲硅烷氧基 )-N-(3,3-二苯基丙基)-1-丙胺,然后与2,6-二甲基-5-甲氧羰基-4-(3-硝基苯基)-1,4-二氢吡啶-3-羰基氯反应 2小时结晶,得到盐酸氯卡地平。

    Process for the preparation of lercanidipine
    36.
    发明授权
    Process for the preparation of lercanidipine 失效
    氯卡地平的制备方法

    公开(公告)号:US07687653B2

    公开(公告)日:2010-03-30

    申请号:US11570533

    申请日:2005-06-15

    CPC classification number: C07D211/90 C07D211/82

    Abstract: The invention provides a novel process for the preparation of lercanidipine or a pharmaceutical acceptable salt using novel intermediates. Thus, 2,N-dimethyl-N-(3,3-diphenylpropyl)-1-amino-2-propanol is reacted with trimethylsilyl chloride in presence of triethyl amine in methylene chloride to give 2,N-dimethyl-2-(trimethylsilyloxy)-N-(3,3-diphenylpropyl)-1-propanamine, which is then reacted with 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carbonyl chloride for 2 hours and crystallized to obtain lercanidipine hydrochloride.

    Abstract translation: 本发明提供了使用新型中间体制备氯卡地平或药学上可接受的盐的新方法。 因此,在三乙基胺的二氯甲烷存在下,使2,N-二甲基-N-(3,3-二苯基丙基)-1-氨基-2-丙醇与三甲基甲硅烷基氯反应,得到2,N-二甲基-2-(三甲基甲硅烷氧基 )-N-(3,3-二苯基丙基)-1-丙胺,然后与2,6-二甲基-5-甲氧羰基-4-(3-硝基苯基)-1,4-二氢吡啶-3-羰基氯反应 2小时结晶,得到盐酸氯卡地平。

    Ensuring data persistence and consistency in enterprise storage backup systems
    37.
    发明授权
    Ensuring data persistence and consistency in enterprise storage backup systems 有权
    确保企业存储备份系统中的数据持久性和一致性

    公开(公告)号:US07634507B2

    公开(公告)日:2009-12-15

    申请号:US11513556

    申请日:2006-08-30

    Abstract: Ensuring data persistence and consistency in enterprise storage backup systems method and apparatus are disclosed. In one embodiment, a method includes creating a data log structure (e.g., a log file) on a storage device (e.g., a Serial ATA drive, a SCSI drive, a SAS drive, a storage are network, etc) coupled to an application server to store a backup data generated by a filter module in a continuous backup environment and buffering the backup data generated by the filter module through a memory module that transfers the backup data to the data log structure on the storage device based on an occurrence of an event. The data log structure may be created by configuring a portion of the storage device as a dedicated resource available to the memory module to copy the backup data and the data log structure may be a file on the storage device coupled to the application server having the file system.

    Abstract translation: 公开了企业存储备份系统方法和装置的数据持久性和一致性。 在一个实施例中,一种方法包括在耦合到应用程序的存储设备(例如,串行ATA驱动器,SCSI驱动器,SAS驱动器,存储器是网络等)上创建数据记录结构(例如,日志文件) 服务器,用于将由过滤器模块生成的备份数据存储在连续备份环境中,并且通过存储器模块缓冲由过滤器模块产生的备份数据,所述存储器模块基于存储设备的发生将备份数据传送到存储设备上的数据记录结构 事件。 可以通过将存储设备的一部分配置为可用于存储器模块的专用资源来复制备份数据来创建数据记录结构,并且数据记录结构可以是耦合到具有该文件的应用服务器的存储设备上的文件 系统。

    Method and system for remote diagnosis of a device over a communication network
    39.
    发明申请
    Method and system for remote diagnosis of a device over a communication network 审中-公开
    通过通信网络远程诊断设备的方法和系统

    公开(公告)号:US20080267169A1

    公开(公告)日:2008-10-30

    申请号:US11790507

    申请日:2007-04-26

    Abstract: A device in a voice over packet (VOP) network includes a transceiver operable to transmit and receive session initiation protocol (SIP) communications over at least a portion of a VOP network. Also included is a processor cooperatively operable with the transceiver. The processor is configured to facilitate, responsive to receipt of an invite request, determining if the invite request is a diagnostic invite. If the invite request is a diagnostic invite, then the audible alert and display of caller id are suppressed. The processor is configured to generate a final response to establish two-way media flow and a dialog. After the dialog is established, diagnostics is launched on the device, and responsive to receipt of diagnostic information requests and after two-way media flow is established, the device responds with diagnostic information responses.

    Abstract translation: 语音分组(VOP)网络中的设备包括可用于在VOP网络的至少一部分上发送和接收会话发起协议(SIP)通信的收发机。 还包括与收发器协同工作的处理器。 处理器被配置为便于响应于收到邀请请求,确定邀请请求是否是诊断邀请。 如果邀请请求是诊断邀请,则抑制呼叫者ID的听觉警报和显示。 处理器被配置为生成最终响应以建立双向媒体流和对话。 对话框建立完成后,在设备上启动诊断程序,响应收到诊断信息请求,建立双向媒体流后,设备将以诊断信息响应进行响应。

Patent Agency Ranking