公开(公告)号：US20090324618A1

公开(公告)日：2009-12-31

申请号：US12294195

申请日：2007-03-26

申请人： Scott A. Armstrong ,  Andrei V. Krivtsov

发明人： Scott A. Armstrong ,  Andrei V. Krivtsov

IPC分类号： A61K39/395 ,  C12Q1/68 ,  A61K31/7088 ,  A61K31/7105 ,  C12N5/06 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57426

摘要： The present invention relates to compounds and methods which are useful in molecular investigations of target genes, as well as their encoded RNAs and protein, belonging to signature self renewal programs in leukemia and/or cancer stem cells. Data herein shows that leukemia stem cells can be generated from committed progenitors without widespread reprogramming of gene expression, and wherein a leukemia self-renewal associated signature is activated in the process.

摘要翻译： 本发明涉及可用于靶基因的分子研究的化合物和方法，以及它们编码的RNA和蛋白质，属于白血病和/或癌干细胞中的特征自我更新程序。 本文的数据表明，白血病干细胞可以从未经广泛重新编程基因表达的定型祖细胞产生，并且其中白血病自我更新相关的特征在该过程中被激活。

公开(公告)号：US07011947B2

公开(公告)日：2006-03-14

申请号：US10198064

申请日：2002-07-17

申请人： Todd R. Golub ,  Scott A. Armstrong ,  Stanley J. Korsmeyer

发明人： Todd R. Golub ,  Scott A. Armstrong ,  Stanley J. Korsmeyer

IPC分类号： C12Q1/68 ,  C12Q1/02 ,  G01N33/53

CPC分类号： G01N33/57426 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N2333/475 ,  G01N2800/52

摘要： The present invention relates to the diagnosis of mixed lineage leukemia (MLL), acute lymphoblastic leukemia (ALL), and acute myelogenous leukemia (AML) according to the gene expression profile of a sample from an individual, as well as to methods of therapy and screening that utilize the genes identified herein as targets.