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1.发明授权公开(公告)号：US07011947B2
公开(公告)日：2006-03-14
申请号：US10198064
申请日：2002-07-17
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N2333/475 , G01N2800/52
摘要： The present invention relates to the diagnosis of mixed lineage leukemia (MLL), acute lymphoblastic leukemia (ALL), and acute myelogenous leukemia (AML) according to the gene expression profile of a sample from an individual, as well as to methods of therapy and screening that utilize the genes identified herein as targets.
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公开(公告)号：US20170209458A9
公开(公告)日：2017-07-27
申请号：US14928223
申请日：2015-10-30
IPC分类号： A61K31/553
CPC分类号： A61K31/553
摘要： The present invention relates to a method of treating a warm-blooded animal, especially a human, having Mixed Lineage Leukemia (MLL rearranged ALL) comprising administering to said animal a therapeutically effective amount of a staurosporine derivative, especially PKC412 or a pharmaceutically acceptable salt thereof, alone or in combination with further therapeutic measures, for example, those defined herein; to the use of a staurosporine derivative for the preparation of a medicament for the treatment of MLL rearranged ALL; and to a commercial package comprising a staurosporine derivative together with instructions for its use in the treatment of MLL rearranged ALL.
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公开(公告)号：US08478420B2
公开(公告)日：2013-07-02
申请号：US11457033
申请日：2006-07-12
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N1/36142 , A61N1/36153 , A61N1/3704
摘要： A method is provided including delivering at least one electrical signal to tissue of a patient through an electrode. The method further includes assessing whether a net charge remains on the electrode a predetermined period of time after the delivery of the electrical signal. Systems for delivering such a signal, and assessing whether a net charge remains on the electrode providing the signal, are also provided.
摘要翻译： 提供了一种方法，包括通过电极将至少一个电信号递送给患者的组织。 该方法还包括评估在电信号传递之后预定时间段内电极是否保留在电极上。 还提供了用于传送这种信号的系统，以及评估净电荷是否保留在提供信号的电极上。
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公开(公告)号：US08437853B2
公开(公告)日：2013-05-07
申请号：US13359720
申请日：2012-01-27
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/36114 , A61N1/36142 , A61N1/36146 , A61N1/3718
摘要： An implantable medical device (IMD) may include a lead circuit including a first node configured to be coupled to a first lead that may be coupled to a first target tissue and including a second node configured to be coupled to a second lead that may be coupled to a second target tissue. The IMD may include an impedance unit that may determine at least one characteristic of coupled energy associated with the lead circuit, where the coupled energy may be produced by a source external to the IMD. The impedance unit may provide an impedance between the first node and the second node, where the impedance is selected based at least in part on a characteristic of the coupled energy. The impedance is selected to reduce the coupled energy or a negative effect associated with functionality of the IMD induced by the coupled energy.
摘要翻译： 可植入医疗装置（IMD）可以包括引线电路，其包括被配置为耦合到第一引线的第一节点，第一引线可以耦合到第一目标组织，并且包括被配置为耦合到第二引线的第二节点， 到第二靶组织。 IMD可以包括阻抗单元，其可以确定与引线电路相关联的耦合能量的至少一个特性，其中耦合能量可以由IMD外部的源产生。 阻抗单元可以在第一节点和第二节点之间提供阻抗，其中至少部分地基于耦合能量的特性来选择阻抗。 选择阻抗以减少耦合能量或与由耦合能量引起的IMD的功能相关联的负面影响。
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公开(公告)号：US20090324618A1
公开(公告)日：2009-12-31
申请号：US12294195
申请日：2007-03-26
IPC分类号： A61K39/395 , C12Q1/68 , A61K31/7088 , A61K31/7105 , C12N5/06 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/57426
摘要： The present invention relates to compounds and methods which are useful in molecular investigations of target genes, as well as their encoded RNAs and protein, belonging to signature self renewal programs in leukemia and/or cancer stem cells. Data herein shows that leukemia stem cells can be generated from committed progenitors without widespread reprogramming of gene expression, and wherein a leukemia self-renewal associated signature is activated in the process.
摘要翻译： 本发明涉及可用于靶基因的分子研究的化合物和方法，以及它们编码的RNA和蛋白质，属于白血病和/或癌干细胞中的特征自我更新程序。 本文的数据表明，白血病干细胞可以从未经广泛重新编程基因表达的定型祖细胞产生，并且其中白血病自我更新相关的特征在该过程中被激活。
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公开(公告)号：US07835796B2
公开(公告)日：2010-11-16
申请号：US11118452
申请日：2005-04-29
IPC分类号： A61N1/00
CPC分类号： A61N1/36007 , A61F5/0003
摘要： A method and apparatus for treatment of an eating disorder includes electrically, mechanically and/or pharmaceutically/chemically stimulating a of the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. The device may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. An implantable stimulus generator may be operatively coupled to a nerve electrode, pressure device or chemical outlet to apply a defined signal to a selected nerve branch. The implantable stimulus generator is programmable to allow clinician programming of defined signal parameters effective to treat the eating disorder of the patient. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译： 用于治疗进食障碍的方法和装置包括电，机械和/或药学/化学刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导传入 迷走神经的动作电位。 该装置可以在植入之后进行非侵入性调节，以对患者的胃肠道提供增加或减少的限制。 每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。 可植入刺激发生器可以可操作地耦合到神经电极，压力装置或化学品出口以将所定义的信号施加到所选择的神经分支。 可植入刺激发生器是可编程的，以允许临床医生对限定的信号参数进行编程，以有效地治疗患者的进食障碍。 还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。
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公开(公告)号：US07711426B2
公开(公告)日：2010-05-04
申请号：US11588798
申请日：2006-10-27
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/3708 , A61N1/378
摘要： A method and an apparatus for determining a time period remaining in a useful life of an energy storage device in an implantable medical device. The method may include measuring a voltage of the energy storage device to produce a measured voltage, and comparing the measured voltage to a transition voltage. While the measured voltage is greater than or equal to the transition voltage, the time period remaining in the energy storage device's useful life is approximated based upon a function of charge depleted. While the measured voltage is less than the transition voltage, the time period remaining in the energy storage device's useful life is approximated based upon a higher order polynomial function of the measured voltage. The transition voltage corresponds to a predetermined point on a energy storage device voltage depletion curve representing the voltage across the energy storage device over time.
摘要翻译： 一种用于确定可植入医疗装置中的能量存储装置的使用寿命中剩余的时间段的方法和装置。 该方法可以包括测量能量存储装置的电压以产生测量的电压，并将测量的电压与转换电压进行比较。 当测量的电压大于或等于转换电压时，能量存储器件的使用寿命中剩余的时间段基于电荷耗尽的函数近似。 当测量的电压小于转换电压时，能量存储器件的使用寿命中剩余的时间段基于所测量的电压的较高阶多项式函数近似。 转换电压对应于表示能量存储装置上的电压随时间的电压耗尽曲线上的预定点。
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公开(公告)号：US07711419B2
公开(公告)日：2010-05-04
申请号：US11180745
申请日：2005-07-13
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/36082 , A61N1/36114 , A61N1/375
摘要： A method, system, and an apparatus for providing a therapy neurostimulation signal. The apparatus includes a sealed housing being of a total volume of less than about 14.5 cc and a power supply contained within the sealed housing. The power supply includes a charge capacity of at least about 100 milliAmpHours. The apparatus also includes a controller to control an operation of the power supply and to provide an electrical neurostimulation signal for stimulating a portion of a neural tissue. The apparatus also provides for implementing an interrupt-driven architecture into an implantable medical device.
摘要翻译： 一种用于提供治疗神经刺激信号的方法，系统和装置。 该设备包括总体积小于约14.5cc的密封壳体和包含在密封壳体内的电源。 电源包括至少约100毫安小时的充电容量。 该装置还包括控制器，用于控制电源的操作并提供用于刺激神经组织的一部分的电神经刺激信号。 该装置还提供将中断驱动架构实现到可植入医疗装置中。
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9.发明授权公开(公告)号：US07310557B2
公开(公告)日：2007-12-18
申请号：US11118861
申请日：2005-04-29
IPC分类号： A61N1/00
CPC分类号： A61F5/0026 , A61F5/005 , A61N1/36007 , A61N1/36082 , A61N1/36185 , A61N1/3686
摘要： A method and apparatus for treatment of an eating disorder includes electrically, mechanically and/or pharmaceutically/chemically stimulating a of the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. The device may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. An implantable stimulus generator may be operatively coupled to a nerve electrode, pressure device or chemical outlet to apply a defined signal to a selected nerve branch. The implantable stimulus generator is programmable to allow clinician programming of defined signal parameters effective to treat the eating disorder of the patient. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译： 用于治疗进食障碍的方法和装置包括电，机械和/或药学/化学刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导传入 迷走神经的动作电位。 该装置可以在植入之后进行非侵入性调节，以对患者的胃肠道提供增加或减少的限制。 每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。 可植入刺激发生器可以可操作地耦合到神经电极，压力装置或化学品出口以将所定义的信号施加到所选择的神经分支。 可植入刺激发生器是可编程的，以允许临床医生对限定的信号参数进行编程，以有效地治疗患者的进食障碍。 还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。
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公开(公告)号：US08560070B2
公开(公告)日：2013-10-15
申请号：US12725962
申请日：2010-03-17
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/3708 , A61N1/378
摘要： A method and an apparatus for determining a time period remaining in a useful life of an energy storage device in an implantable medical device. The method may include measuring a voltage of the energy storage device to produce a measured voltage, and comparing the measured voltage to a transition voltage. While the measured voltage is greater than or equal to the transition voltage, the time period remaining in the energy storage device's useful life is approximated based upon a function of charge depleted. While the measured voltage is less than the transition voltage, the time period remaining in the energy storage device's useful life is approximated based upon a higher order polynomial function of the measured voltage. The transition voltage corresponds to a predetermined point on a energy storage device voltage depletion curve representing the voltage across the energy storage device over time.
摘要翻译： 一种用于确定可植入医疗装置中的能量存储装置的使用寿命中剩余的时间段的方法和装置。 该方法可以包括测量能量存储装置的电压以产生测量的电压，并将测量的电压与转换电压进行比较。 当测量的电压大于或等于转换电压时，能量存储器件的使用寿命中剩余的时间段基于电荷耗尽的函数近似。 当测量的电压小于转换电压时，能量存储器件的使用寿命中剩余的时间段基于所测量的电压的较高阶多项式函数近似。 转换电压对应于表示能量存储装置上的电压随时间的电压耗尽曲线上的预定点。
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