公开(公告)号：US4565815A

公开(公告)日：1986-01-21

申请号：US614454

申请日：1984-05-25

申请人： Sun H. Kim ,  Jacques-Pierre Moreau

发明人： Sun H. Kim ,  Jacques-Pierre Moreau

IPC分类号： A61K31/53 ,  A61P1/04 ,  C07D487/04 ,  A61K31/415 ,  C07D403/14 ,  C07D407/14

CPC分类号： C07D487/04

摘要： A compound having anti-ulcer activity and having the formula ##STR1## wherein D is H, SH, NH.sub.2, OH, R.sup.4 S where R.sup.4 is a lower alkyl group; E is OH or NH.sub.2 ; J is H or aryl; X is CH or N; Y is CH, N, or CT, wherein T is a halogen; Z is CH or N; A is ##STR2## and replaces a hydrogen of D, X, or E; R.sup.1 is H or CH.sub.3 ; L is CH.sub.2 S; Q is O or CH.sub.2 S; n is 0 or 1; 2 m 4; each R.sup.2 and R.sup.3, independently, is H, lower alkyl, cycloalkyl, or arylalkyl; or R.sup.2 and R.sup.3, together with the nitrogen atom to which they are attached, form a 4, 5, or 6 membered heterocyclic ring containing 0, 1, or 2 oxygen atoms and 1, 2, or 3 nitrogen atoms and being unsubstituted or lower alkyl substituted; or a pharmaceutically acceptable salt thereof.

摘要翻译： 具有抗溃疡活性并具有下式的化合物：其中D是H，SH，NH 2，OH，R 4，其中R 4是低级烷基; E是OH或NH 2; J为H或芳基; X是CH或N; Y是CH，N或CT，其中T是卤素; Z是CH或N; A是 + TR ，代替D，X或E的氢; R1是H或CH3; L是CH2S; Q是O或CH2S; n为0或1; 2 m 4; 每个R 2和R 3独立地是H，低级烷基，环烷基或芳基烷基; 或R 2和R 3与它们所连接的氮原子一起形成含有0,1或2个氧原子和1,2或3个氮原子的4,5或6元杂环，并且是未取代的或低级的 烷基取代; 或其药学上可接受的盐。

公开(公告)号：US5773455A

公开(公告)日：1998-06-30

申请号：US672474

申请日：1996-06-28

申请人： Zheng Xin Dong ,  Sun H. Kim

发明人： Zheng Xin Dong ,  Sun H. Kim

IPC分类号： C07D277/02 ,  A61K31/33 ,  A61K31/426 ,  A61K31/427 ,  A61K38/55 ,  A61P9/08 ,  A61P35/00 ,  A61P43/00 ,  C07D277/04 ,  C07D277/06 ,  C07K5/00 ,  C07K5/02 ,  A01N43/78

CPC分类号： C07D277/06

摘要： A family of compounds capable of inhibiting the activity of prenyl transferases. The compounds are covered by one of the two following formulas: ##STR1## Each of the R groups is defined in the disclosure.

摘要翻译： 能够抑制异戊烯基转移酶活性的化合物家族。 这些化合物被以下两个下式之一覆盖： 本公开中定义了每个R基团。

公开(公告)号：US4871870A

公开(公告)日：1989-10-03

申请号：US25850

申请日：1987-03-16

申请人： Sun H. Kim

发明人： Sun H. Kim

IPC分类号： C07C229/16 ,  A61K31/195 ,  A61K31/22 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  C07C67/00 ,  C07C227/00 ,  C07C227/16

CPC分类号： A61K31/195

摘要： A compound having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein A is an amino acid identifying group; B is a hydrogen atom, an alkyl group having 1-5, inclusive, carbon atoms, or an aralkyl group having 6-12, inclusive, carbon atoms; carbon atom 2 is of the R configuration; and carbon atom 3 is of the R configuration. The compounds of the invention are effective in augmenting immunological responses and are useful therefore in the treatment of diseases such as cancer, viral infections, bacterial infections, and arthritis.

公开(公告)号：US4785003A

公开(公告)日：1988-11-15

申请号：US821071

申请日：1986-01-21

申请人： Sun H. Kim

发明人： Sun H. Kim

IPC分类号： A61K38/00 ,  C07D207/28 ,  C07D403/12 ,  C07D471/04 ,  C07K5/06 ,  C07K5/078 ,  A61K31/47 ,  C07D217/16

CPC分类号： C07D403/12 ,  C07D207/28 ,  C07D471/04 ,  C07K5/06026 ,  C07K5/06173 ,  A61K38/00

摘要： A compound having the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein A is N-AC-Sar, pGlu, or homo-pGlu-; B is an aryl group, a heteroaryl group, a cycloalkyl group, an aralkyl group, a heteroalkyl group, a heteroaralkyl group, a benzoyl group, an alkyl group, an acetyl group, or a substituted aryl group wherein the substituent is halogen, hydroxy, alkoxy, nitro, cyano, or hydroxyalkyl; E is H or an alkyl group; B and E being separate substituents or, together with C.sub.1 and the nitrogen atom to which B is attached, forming a 5,6, or 7-membered ring; m is an integer between 0 and 4; either F is ##STR2## wherein R is an alkoxy group or an aralkoxy group; or F is ##STR3## and is capable of forming a 6-membered ring with the nitrogen atom of A, provided that F can only be ##STR4## forming a ring with A when A is pGlu or homo-pGlu.

摘要翻译： 具有式“IMAGE”的化合物或其药学上可接受的盐，其中A是N-AC-Sar，pGlu或homo-pGlu-; B是芳基，杂芳基，环烷基，芳烷基，杂烷基，杂芳烷基，苯甲酰基，烷基，乙酰基或取代的芳基，其中取代基是卤素，羟基 ，烷氧基，硝基，氰基或羟基烷基; E是H或烷基; B和E是独立的取代基，或者与C1和与B连接的氮原子一起形成5,6或7-元环; m是0和4之间的整数; F是F，其中R是烷氧基或芳烷氧基; 或者F是，并且能够与A的氮原子形成6元环，条件是当A是pGlu或homo-pGlu时，F只能与A形成环。