专利检索 ap:"UNIVERSITE DE LILLE" 第 4 页

31.

发明申请
AGENTS FOR THE TREATMENT OF PATIENTS WITH NSCLC AND METHODS TO PREDICT RESPONSE 有权

公开(公告)号：US20220389420A1

公开(公告)日：2022-12-08

申请号：US16463886

申请日：2017-11-23

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE LILLE , UNIVERSITE DE NICE SOPHIA ANTIPOLIS , CENTRE HOSPITALIER ET UNIVERSITAIRE DE LILLE

发明人： Nicolas POTTIER , Christelle CAUFFIEZ , Grégoire SAVARY , Edmone DEWAELES , Cynthia VAN DER HAUWAERT , Bernard MARI

IPC分类号： C12N15/113 , A61K33/243 , A61P35/00 , A61P11/00 , C12Q1/6886

摘要： Agents for the treatment of patients having non-small cell lung cancer and methods of diagnostics related include an inhibitor of miR 24 3p, a locked nucleic acid, including methods of predicting response to platinum-based chemotherapy, for patients having, or suspected of having, non-small cell lung cancer.

32.

发明申请
NOVEL LACTIC ACID BACTERIA STRAIN - ANTIBACTERIAL PEPTIDES PRODUCED BY SAID STRAIN AND RELATED PHARMACEUTICAL COMPOSITIONS 有权

公开(公告)号：US20220249583A1

公开(公告)日：2022-08-11

申请号：US17616156

申请日：2020-06-03

申请人： UNIVERSITE DE LILLE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , YNCREA HAUTS DE FRANCE , UNIVERSITE DU LITTORAL CÔTE D'OPALE , UNIVERSITE D'ARTOIS , UNIVERSITE POLYTECHNIQUE DES HAUTS DE FRANCE , CENTRALE LILLE INSTITUT

发明人： RABAH BOUKHERROUB , DJAMEL DRIDER , NOURA HAZIME , YANATH BELGUESMIA , KAMEL BENDJEDDOU

IPC分类号： A61K35/747 , A61K45/06 , A61K38/16 , A61K36/02 , A61P31/00

摘要： A Lactobacillus paracasei strain deposited at the CNCM under reference number CNCM I-5369. A mixture of the peptides having the following sequences: (SEQ ID NO 1), (SEQ ID NO 2), (SEQ ID NO 3), (SEQ ID NO 4) and (SEQ ID NO 5) and to one of the above-mentioned peptides in combination with at least one component chosen among: essential oils and particularly among essential oil of mint, essential oil of thyme, essential oil of pine tree, menthol, thymol, pinene, vitamin C, formic acid, propionic acid, citric acid, sorbic acid and lactic acid and/or a nanoparticle which may be loaded with said active ingredients.

33.

发明申请
PHONON PARAMETRIC OSCILLATOR 有权

公开(公告)号：US20210035549A1

公开(公告)日：2021-02-04

申请号：US16969054

申请日：2019-02-08

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE LILLE , YNCREA HAUTS DE FRANCE ISEN LILLE

发明人： Arnaud DEVOS

IPC分类号： G10K15/04

摘要： A phonon parametric oscillator is provided. The phonon parametric oscillator comprises a laser for periodically emitting brief optical pulses (IL), an assembly for generating acoustic pulses (IA) and a medium for coupling the acoustic pulses to an object (O), the assembly for generating acoustic pulses comprising an entrance face, an exit face, a conversion medium for converting the brief optical pulses into acoustic pulses and a propagation medium for propagating said acoustic pulses, the entrance and exit faces being reflective to the acoustic pulses, the propagation medium having a defined thickness, the exit face making contact with the coupling medium. In the phonon parametric oscillator according to the invention, the round-trip time of an acoustic pulse due to reflection from the entrance and exit faces, is equal to the emission period (τ) of the laser, so that the reflected acoustic pulse is in phase with the following acoustic pulse.

34.

发明申请
MODERATELY MULTIMODAL AMPLIFYING FIBRE 审中-公开

公开(公告)号：US20200313382A1

公开(公告)日：2020-10-01

申请号：US16628424

申请日：2018-06-29

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE LILLE

发明人： Jean-Baptiste TRINEL , Guillaume LE COCQ , Laurent BIGOT , Géraud BOUWMANS

IPC分类号： H01S3/067

摘要： According to one aspect, a few-mode amplifying fiber in a given spectral band of use is provided. The few-mode amplifying fiber comprises a cladding having a given refractive index (n0) and at least one core of refractive index and of dimensions suited to the propagation of a finite number of spatial modes in the spectral band of use of the fiber, a spatial propagation mode corresponding to a channel for transporting information. The core comprises a first solid material having a given first refractive index (n1) strictly greater than the refractive index of the cladding (n0), and, within said first material, inclusions spatially separated from one another, formed by longitudinal bars comprising a second solid material having a second refractive index (n2) strictly greater than the first refractive index (n1), at least one of said inclusions being actively doped.

35.

发明授权
Light emitting system 有权

公开(公告)号：US10561856B2

公开(公告)日：2020-02-18

申请号：US15025623

申请日：2014-11-25

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE LILLE 2 DROIT ET SANTE , CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)

发明人： Serge Mordon , Nacim Betrouni , Laurent Mortier

IPC分类号： A61N5/06

摘要： The system comprises: —a bundle of light fibers (11) connected to a light-emitting source (8), and both transmitting light inside the light fiber and emitting light toward a treatment volume (V), —a temperature-modifying system attached to the bundle of light fibers (11) to modify temperature in the treatment volume (V).

36.

发明授权
Imidazol- or 1,2,4-triazol-derivatives and their use 有权

公开(公告)号：US10323016B2

公开(公告)日：2019-06-18

申请号：US15315270

申请日：2015-06-11

申请人： UNIVERSITE DE LILLE 2 DROIT ET SANTE , INSTITUT PASTEUR DE LILLE , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

发明人： Julie Charton , Benoit Deprez , Florence Leroux , Bart Staels , Anne Muhr-Tailleux , Nathalie Hennuyer , Sophie Lestavel , Manuel Lassalle , Barbara Dubanchet

IPC分类号： C07D403/12 , C07D401/12 , C07D233/88 , C07D249/14

摘要： The present invention is directed to novel compounds of formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.

37.

发明申请
OPTICAL FIBER MODE SCRAMBLER 审中-公开

公开(公告)号：US20190033525A1

公开(公告)日：2019-01-31

申请号：US16074937

申请日：2017-02-03

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE DE LILLE 2 DROIT ET SANTE , CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU)

发明人： Serge MORDON , Pascal DELEPÔRTE , Nacim BETROUNI

IPC分类号： G02B6/14 , H04B10/2581

CPC分类号： G02B6/14 , H04B10/2581

摘要： An optical fiber mode scrambler adapted to give a determined bending to an optical fiber inserted in the mode scrambler, the mode scrambler having a general extension direction X, the mode scrambler having a morphology adapted to give the optical fiber a direction along X at the entry of the scrambler, and then to bend the fiber to bring the fiber substantially in the X, Y plan in the −X and Y directions, before bringing the fiber in a rotation around the X axis substantially in the Y, Z plan in the anti clockwise direction for one full rotation, and then bending the fiber to bring the fiber substantially in the X, Y plan in the −X and −Y directions, and then bending the fiber to give the optical fiber a direction along X at the exit of the scrambler.

38.

发明授权
Pharmaceutical solution comprising dopamine for use in treating parkinson's disease 有权

公开(公告)号：US10105326B2

公开(公告)日：2018-10-23

申请号：US15310364

申请日：2015-05-12

申请人： CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE (CHRU) , UNIVERSITE DE LILLE 2 DROIT ET SANTE , UNIVERSITE DU LITTORAL COTE D'OPALE

发明人： David Devos , Caroline Moreau , Charlotte Laloux , Jean-christophe Devedjian

IPC分类号： A61K31/137 , A61K9/08 , A61P25/16 , A61K9/00

摘要： The present invention is directed to pharmaceutical solution comprising at least dopamine for use in treating Parkinson's disease, wherein said pharmaceutical solution is kept under anaerobic conditions from its formulation to its administration.