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公开(公告)号：US11499284B2
公开(公告)日：2022-11-15
申请号：US17334701
申请日：2021-05-29
Inventor： Fuming Wang , Chengchao Guo , Chaojie Wang , Mingsheng Shi , Peng Zhao , Yanhui Pan , Xianfeng Zhao , Binghan Xue , Yanjie Hao , Xijun Zhang , Yangyang Xia , Yingli Wang
Abstract: A trough plate for constructing a locked polymer anti-seepage wall includes a plate body, a guide tube, a grouting pipe and an anti-blocking head. A construction method of the locked polymer anti-seepage wall includes the steps of positioning an Nth trough plate and then pressing the Nth trough plate into ground, wherein N is a natural number larger than and equal to 1; engaging an (N+1)th trough plate with the Nth trough plate, and then pressing the (N+1)th trough plate into the ground; connecting a grouting pipe of the Nth trough plate with a grouting machine, pulling out the Nth trough plate, and simultaneously grouting through the grouting pipe of the Nth trough plate by the grouting machine; and repeating the steps (B) and (C) till the locked polymer anti-seepage wall is completed, wherein the steps (B) and (C) are repeated every time, N is automatically increased by 1.
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公开(公告)号：US20220309214A1
公开(公告)日：2022-09-29
申请号：US17214866
申请日：2021-03-28
Applicant: Zhengzhou University of Aeronautics
Inventor： Litao Zhang , Yingchao Zhao , Yongwei Zhou , Yifan Zhang , Xin Liao , Erbao Feng
Abstract: The present invention relates to a CFD numerical simulation based fluid equipment resistance optimization algorithm, including the following steps: establishing a fluid equipment unit library; establishing CFD models of fluid equipment units in the fluid equipment unit library, and obtaining a correspondence between a flow rate and a resistance of each fluid equipment unit based on a CFD model of the fluid equipment unit; obtaining fluid equipment units that constitute to-be-tested fluid equipment, and a quantity and a connection sequence of the fluid equipment units; calculating a resistance of each fluid equipment unit based on a flow rate and a correspondence between the flow rate and the resistance of each fluid equipment unit; and adding up resistances of the fluid equipment units in the to-be-tested fluid equipment based on their connection sequence, to obtain a resistance of the to-be-tested fluid equipment.
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公开(公告)号：US11455767B1
公开(公告)日：2022-09-27
申请号：US17547285
申请日：2021-12-10
Applicant: ZHENGZHOU UNIVERSITY OF LIGHT INDUSTRY
Inventor： Hao Li , Bing Li , Haoqi Wang , Gen Liu , Guizhong Xie , Chunya Sun , Rongjie Huang , Xiaoyu Wen , Yuyan Zhang , Zhongshang Zhai , Fuquan Nie
Abstract: An intelligent material completeness detection and configuration method based on digital twin and augmented reality (AR) includes: constructing a digital twin model base and knowledge base of an incomplete material; importing the digital twin model base and knowledge base of the incomplete material respectively into a model database and a knowledge database in a digital twin system database; sending materials to be detected into a vision-based material completeness detection platform, sorting out an incomplete material, acquiring corresponding data, and importing the data into an incomplete material information database; performing, based on an AR device, perception and reconstruction of incomplete material configuration; matching a configuration plan of the incomplete material in a digital twin relational database, and performing a virtual-real fusion in the AR device; and allowing, a worker to rapidly and accurately find a location and problem type of the incomplete material and configuration the incomplete material.
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公开(公告)号：US20220234963A1
公开(公告)日：2022-07-28
申请号：US17155698
申请日：2021-01-22
Applicant: Zhengzhou University
Inventor： Zon-Han Wei , Yen-Ya Hsu
Abstract: A method for making moldable and cuttable composite material for magnetic moment calibration of samples with specific shapes is provided. The method is used to quantify a magnetic moment per unit weight from the moldable and cuttable composite material. The moldable and cuttable composite material is made by a non-magnetic matrix with superparamagnetic particles, paramagnetic particles, or ferromagnetic particles without anisotropy. Then, the moldable and cuttable composite material is shaped and tailored into calibration samples with specific shapes. The method provides a method for making calibration samples with the specific shapes, wherein the calibration samples are easily shaped and tailored to same or similar shapes and sizes as test samples. The method improves an original method for making a standard calibration sample, wherein the original method only used pure nickel ball or high purity palladium wire structure.
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公开(公告)号：US11306129B2
公开(公告)日：2022-04-19
申请号：US15758853
申请日：2016-09-09
Inventor： Yaohe Wang , Pengju Wang , Lemoine Nick , Dongling Gao
IPC: A61K35/76 , A61K35/761 , A61K35/768 , C07K14/54 , A61K48/00 , C12N15/863 , C12N15/861 , C12N15/869 , A61K38/20 , A61P35/00 , C12N15/86
Abstract: The present invention discloses a modified interleukin 12 (nsIL-12) and its gene, recombinant vector and use in manufacture of a medicament for treatment of tumors. When the oncolytic adenovirus vector carrying the modified interleukin 12 gene targets tumor tissue, the modified interleukin 12 is continuously expressed at a low level and mainly distributed in the local tumor tissue, which improves the specificity to tumor cells and reduces the systemic toxicity of interleukin 12; the modified interleukin 12 shows stronger inhibitory effect on tumor growth in intraperitoneally disseminated tumors and orthotopic tumors, and has low toxicity. The modified interleukin 12 armed oncolytic viruses show excellent anti-tumor effects, with a significant regression of tumors and lower toxicity compared with the existing IL-12 armed virus.
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Patent Agency Ranking
公开(公告)号：US11289878B2
公开(公告)日：2022-03-29
申请号：US17098942
申请日：2020-11-16
Applicant: ZHENGZHOU UNIVERSITY OF AERONAUTICS
Inventor： Yan Li , Facheng Zhong , Yanyan Wang , Peng Yang , Kun Xu , Pei Ding , Fanguang Zeng
Abstract: The disclosure provides a nanolaser based on a depth-subwavelength graphene-dielectric hyperbolic dispersive cavity, comprising a pumping light source and the depth-subwavelength graphene-dielectric hyperbolic dispersive cavity; wherein the depth-subwavelength graphene-dielectric hyperbolic dispersive cavity is a spherical or hemispherical hyperbolic dispersive microcavity formed by alternately wrapping a dielectric core with graphene layers and dielectric layers. Because the graphene plasmon has unique excellent performances, such as an electrical adjustability, a low intrinsic loss, a high optical field localization, and a continuously adjustable resonance frequency from mid-infrared to terahertz, compared with a common metal-dielectric hyperbolic dispersive characteristic, a graphene-dielectric hyperbolic dispersive metamaterial used by the disclosure not only may highly localize an energy of an electromagnetic wave in a more depth-subwavelength cavity, but also may reduce an ohmic loss and improve a quality factor.
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37.发明授权公开(公告)号：US11279695B2
公开(公告)日：2022-03-22
申请号：US17009821
申请日：2020-09-02
Applicant: Zhengzhou University
Inventor： Guifu Dai , Di Wu , Haiwei Xu , Jiazhen Zhu , Zibo Fu , Zhenzhen Guan , Xiaopei Zhang , Ning Shang , Shuqiu Zhang , Guangming Yan
IPC: C07D407/04 , C07D307/58 , A61P1/16 , A61P13/12 , A61P11/00
Abstract: A compound represented by formula I or II. R1 and R2 are at each occurrence selected from the group consisting of hydrogen, methyl, phenyl, 2-methoxyphenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3,4,5-trimethoxyphenyl, 2-hydroxyphenyl, 3-hydroxyphenyl, 4-hydroxyphenyl, 2-fluorophenyl, 2-chlorophenyl, 2-bromophenyl, 3-fluorophenyl, 3-chlorophenyl, 3-bromophenyl, 4-fluorophenyl, 4-chlorophenyl, 4-bromophenyl, 2-fluoro-3-methoxyphenyl, 3-methoxy-4-chlorophenyl, 2,4-difluorophenyl, 2,4-dichlorophenyl, 2,4-dibromophenyl, 2-fluoro-4-chlorophenyl, 2-bromo-4-chlorophenyl, 3-fluoro-4-chlorophenyl, 3-bromo-4-chlorophenyl, 3,4-difluorophenyl, 3,4-dichlorophenyl, 3,4-dibromophenyl, 2-chloro-4-fluorophenyl, 2-bromo-4-fluorophenyl, 3-chloro-4-fluorophenyl, 3-bromo-4-fluorophenyl, 2-fluoro-4-bromophenyl, 2-chloro-4-bromobenzene group, 3-fluoro-4-bromophenyl, 3-chloro-4-bromophenyl, 2,3,4-trichlorophenyl, 2-methoxy-4-chlorophenyl, 2-hydroxy-4-chlorophenyl, 2-hydroxy-4-methoxyphenyl, 3-fluoro-4-(4-methylpiperazinyl)phenyl, 4-(N,N-dimethylamino)phenyl, and 3-fluoro-4-(4-morpholinyl)phenyl. R3 and R4 are hydrogen, or R3 and R4 are at each occurrence selected from the group consisting of —CH2CH2COOH, —CH2CH2CH2CH2COOH, —CH2CH═CHCH2COOH, and —CH2CH2CH2CH2CH2CH2CH2COOH; or R3 and R4 are —COR5, and R5 is selected from the group consisting of 3-pyridyl, —CH2CH2COOH, —CH2CH2CH2CH2COOH, —CH2CH═CHCH2COOH, and —CH2CH2CH2CH2CH2CH2CH2COOH.
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公开(公告)号：US20210285180A1
公开(公告)日：2021-09-16
申请号：US17334701
申请日：2021-05-29
Inventor： Fuming Wang , Chengchao Guo , Chaojie Wang , Mingsheng Shi , Peng Zhao , Yanhui Pan , Xianfeng Zhao , Binghan Xue , Yanjie Hao , Xijun Zhang , Yangyang Xia , Yingli Wang
Abstract: A trough plate for constructing a locked polymer anti-seepage wall includes a plate body, a guide tube, a grouting pipe and an anti-blocking head. A construction method of the locked polymer anti-seepage wall includes the steps of positioning an Nth trough plate and then pressing the Nth trough plate into ground, wherein N is a natural number larger than and equal to 1; engaging an (N+1)th trough plate with the Nth trough plate, and then pressing the (N+1)th trough plate into the ground; connecting a grouting pipe of the Nth trough plate with a grouting machine, pulling out the Nth trough plate, and simultaneously grouting through the grouting pipe of the Nth trough plate by the grouting machine; and repeating the steps (B) and (C) till the locked polymer anti-seepage wall is completed, wherein the steps (B) and (C) are repeated every time, N is automatically increased by 1.
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公开(公告)号：US20210277513A1
公开(公告)日：2021-09-09
申请号：US15930912
申请日：2020-05-13
Applicant: Zhengzhou University
Inventor： Jilin HE , Benshuang SUN , Yongchun SHU , Yang LIU , Jie CHEN , Xueyun ZENG
IPC: C23C14/34 , C04B35/457
Abstract: A method of preparing an ITO ceramic target includes that: In2O3 powder with mass fraction of 90˜97 and SnO2 powder with mass fraction of 10˜3 are ball-milled and mixed with deionized water, diluent, binder and polymer material by a sand mill to obtain an ITO ceramic slurry with a solid content between 70˜80% and a viscosity between 120˜300 mpa·s, with an average particle size D50 of the mixed powder controlled at 100˜300 nm; the ITO ceramic slurry is shaped by a pressure grouting to obtain an ITO ceramic green body with a relative density of 58˜62%; the ITO ceramic green body is put into a degreasing and sintering integrated furnace, and under a degreasing temperature of 700˜800° C., the ITO ceramic target is degreased in an atmospheric oxygen atmosphere for the time set to 12˜36 hours; the temperature increases from the degreasing temperature to the first sintering temperature of 1,600˜1,650° C.
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公开(公告)号：US10260995B2
公开(公告)日：2019-04-16
申请号：US15807452
申请日：2017-11-08
Applicant: NANJING FORESTRY UNIVERSITY , ZHENGZHOU UNIVERSITY
Inventor： Zeli Que , Xiaolin Yang , Qicheng Teng , Hongyi Lu , Feibin Wang , Zherui Li , Weizhen Cai
Abstract: A test device of universal nail/screw holding power is provided. The device is capable of penetrating a nail/screw into a test piece at any angle and positioning the test piece on which a nail/screw is penetrated at any angle to test the nail/screw holding power. The device includes a base, two opposite supporting plates, two coaxial disks, an upper bearing plate, a lower bearing plate, a side bearing plate, a through groove, a trapezoid slot, and a plurality of trapezoid bolts on the same circumference. When the disk is turned, at least one trapezoid bolt is inserted into the trapezoid slot; when the at least one trapezoid bolt engages with the trapezoid slot and then is tightened up, the at least one trapezoid bolt and the trapezoid slot cooperatively limit the turn of the disk.
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