Patent search ap:("ABBOTT CARDIOVASCULAR SYSTEMS INC.") AND inv:"James Oberhauser" Page 4

31.

发明授权
Stents including poly(L-lactide) formulations that minimize molecular weight drop during processing 有权
Title translation: 支架，包括聚（L-丙交酯）制剂，使加工过程中的分子量下降最小化

公开(公告)号：US08882825B2

公开(公告)日：2014-11-11

申请号：US14022098

申请日：2013-09-09

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Byron Lambert , Yunbing Wang , James Oberhauser

IPC: C08J3/28 , A61L31/00 , A61F2/82 , A61L31/06 , A61L31/14 , A61L31/04

CPC classification number: B29C47/0076 , A61F2/82 , A61L31/041 , A61L31/06 , A61L31/143 , A61L31/148 , B29D23/20 , B29K2005/00 , B29L2023/20 , B29L2031/753 , C08J3/28 , C08J2367/04 , C08L67/04

Abstract: A stent scaffolding including a polymer formulation comprising PLLA and polymandelide is disclosed. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing.

Abstract translation: 公开了一种包括含有PLLA和聚扁桃酸酯的聚合物制剂的支架支架。聚对苯二甲酸丁二醇酯降低加工过程中的分子量下降，特别是在灭菌过程中。支架支架还可包括一种或多种附加的稳定剂，其另外降低加工过程中的分子量下降。

32.

发明申请
BIOABSORBABLE SCAFFOLD WITH PARTICLES PROVIDING DELAYED ACCELERATION OF DEGRADATION 审中-公开
Title translation: 具有提供延迟延迟降解的颗粒的生物可溶性SCAFFOLD

公开(公告)号：US20140319724A1

公开(公告)日：2014-10-30

申请号：US14223908

申请日：2014-03-24

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Yunbing Wang , James Oberhauser

IPC: A61L31/14

CPC classification number: A61F2/82 , A61F2210/0004 , A61F2250/003 , A61L31/10 , A61L31/14 , A61L31/148 , A61L31/16

Abstract: Methods of controlling the degradation profile of a biodegradable stent scaffolding are disclosed. A bioabsorbable scaffold having a plurality of particles incorporated into the scaffolding that accelerate the absorption of the scaffolding after an induction time during degradation is disclosed.

Abstract translation: 公开了控制可生物降解的支架支架的降解特征的方法。公开了一种生物吸收性支架，其具有并入到脚手架中的多个颗粒，其在降解过程中的诱导时间之后加速脚手架的吸收。

33.

发明申请
CONTROLLING MOISTURE IN AND PLASTICIZATION OF BIORESORBABLE POLYMER FOR MELT PROCESSING 审中-公开
Title translation: 控制用于熔融加工的可生物降解聚合物的水分和塑化

公开(公告)号：US20140298675A1

公开(公告)日：2014-10-09

申请号：US14311175

申请日：2014-06-20

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Bethany Steichen , Stephen Pacetti , Manish Gada , Thierry Glauser , Lothar Kleiner , Yunbing Wang , James Oberhauser , Ni Ding

IPC: B29B13/06

CPC classification number: B29C47/0078 , B29B13/06 , B29B13/065 , B29C47/0014 , B29C47/0021 , B29C47/0023 , B29C47/1018 , B29C47/1072 , B29C47/76 , B29C47/92 , B29C2947/922 , B29C2947/92228 , B29C2947/92342 , B29C2947/92695 , B29C2947/92704 , B29C2947/92723 , B29K2995/006

Abstract: Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon.

Abstract translation: 公开了用于在挤出之前控制可生物降解和生物可再吸收的聚合物树脂的含水量的方法和系统，其允许聚合物树脂熔体增塑并低于上限以降低或防止分子量损失。进一步公开的方法涉及用二氧化碳和氟利昂进料到挤出机中的聚合物树脂的增塑。

34.

发明申请
METHOD TO MINIMIZE CHAIN SCISSION AND MONOMER GENERATION IN PROCESSING OF POLY(L-LACTIDE) STENT 审中-公开
Title translation: 减少聚合（L-LACTIDE）STENT处理中的链分离和单体产生的方法

公开(公告)号：US20140288628A1

公开(公告)日：2014-09-25

申请号：US14226727

申请日：2014-03-26

Applicant: Abbott Cardiovascular Systems Inc.

Inventor： Yunbing Wang , James Oberhauser

IPC: A61F2/82 , A61L31/14 , A61F2/958

CPC classification number: A61F2/82 , A61F2/958 , A61F2002/9583 , A61L31/06 , A61L31/148 , H01J2237/31 , C08L67/04

Abstract: Methods of fabricating an implantable medical devices such as stents made from biodegradable polymers are disclosed that reduce or minimize chain scission and monomer generation during processing steps. The method includes processing a poly(L-lactide) resin having an number average molecular weight between 150 to 200 kD in an extruder in a molten state. A poly(L-lactide) tube is formed from the processed resin and a stent is fabricated from the tube. The number average molecular weight of the poly(L-lactide) of the stent after sterilization is 70 to 100 kD.

Abstract translation: 公开了制造可植入医疗装置的方法，例如由可生物降解的聚合物制成的支架，其可减少或最小化加工步骤期间的链断裂和单体产生。该方法包括在熔融状态的挤出机中加工数均分子量为150〜200kD的聚（L-丙交酯）树脂。由处理后的树脂形成聚（L-丙交酯）管，并由管制造支架。灭菌后支架的聚（L-丙交酯）数均分子量为70〜100kD。