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公开(公告)号：US20180325707A1
公开(公告)日：2018-11-15
申请号：US15590817
申请日：2017-05-09
发明人： Jana Buccola , Joel Harrington , Syed Hossainy , Mary Beth Kossuth , Annie Liu , James Oberhauser , Fuh-Wei Tang
摘要： A method of accelerated aging of bioresorbable polymer scaffolds including exposing the scaffold to water is disclosed. The scaffold is exposed to water at a controlled temperature for a selected aging time. The functional outputs, such as radial strength, expandability, and % recoil obtained from aged scaffolds predict those of real-time aging of the scaffold. The accelerated aging factor, which is the required shelf life divided by the aging time, is significantly higher for poly(L-lactide) scaffolds tested than thermal aging.
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公开(公告)号：US09548215B2
公开(公告)日：2017-01-17
申请号：US14250023
申请日：2014-04-10
IPC分类号： A61F2/89 , B23K26/00 , A61F2/95 , B23K26/40 , A61B19/00 , A61B5/00 , H01L21/311 , H01L21/033 , A61L31/14 , A61L31/18 , A61F2/91 , G01B9/02
CPC分类号： A61B5/4851 , A61B5/0066 , A61B5/0084 , A61B5/6852 , A61F2/91 , A61L29/146 , A61L29/18 , A61L31/146 , A61L31/18 , G01B9/02091 , H01L21/0337 , H01L21/31144
摘要： An endoprosthesis, a method for imaging an endoprosthesis, a method of making an endoprosthesis involve a polymeric substrate that has been modified to have voids embedded within the substrate. The voids are sized to scatter optical radiation from within the substrate so that an optical coherence tomography (OCT) image can be obtained in which an interior region of the substrate can be easily differentiated from empty space and other structures that surround the endoprosthesis. The voids allow for OCT visualization of the polymeric substrate which may be difficult to visualize by other methods such as fluoroscopy.
摘要翻译： 内置假体，用于成像内假体的方法，制造内假体的方法涉及已经被修改为具有嵌入衬底内的空隙的聚合物基底。 空隙的大小适于散射来自衬底内的光辐射，使得可以获得光学相干断层摄影（OCT）图像，其中衬底的内部区域可以容易地与空间和围绕内置假体的其他结构区分开。 空隙允许聚合物基底的OCT可视化，其可能难以通过诸如荧光透视的其它方法可视化。
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公开(公告)号：US20140128959A1
公开(公告)日：2014-05-08
申请号：US13998195
申请日：2013-10-09
发明人： David C. Gale , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian , Anthony J. Abbate , Klaus Kleine , Stephen Schaible , Jonathan P. Durcan , Thierry Glauser , Bethany Steichen , James Oberhauser , Manish Gada , Lothar Kleiner , Mary Beth Kossuth , Yunbing Wang , Daniel Castro , David Wrolstad
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2002/91533 , A61F2002/91566 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61L31/06 , A61L31/14 , A61L31/148 , B29C35/045 , B29C49/0005 , B29C49/04 , B29C49/14 , B29C49/4823 , B29C55/24 , B29C2049/0089 , B29C2793/0009 , B29K2067/00 , B29K2067/046 , B29K2105/258 , B29K2995/006 , B29L2031/7534 , C08L67/04
摘要： Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.
摘要翻译： 公开了制造具有增强的断裂韧性的支架的支架和方法。
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4.发明申请公开(公告)号：US20170319363A1
公开(公告)日：2017-11-09
申请号：US15661925
申请日：2017-07-27
CPC分类号： A61F2/90 , A61F2/91 , A61L31/041 , A61L31/06 , A61L31/148
摘要： Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state.
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公开(公告)号：US09211682B2
公开(公告)日：2015-12-15
申请号：US13734879
申请日：2013-01-04
发明人： Thierry Glauser , Vincent Gueriguian , Bethany Steichen , James Oberhauser , Manish Gada , Lothar Kleiner , Mary Beth Kossuth
IPC分类号： B29C55/26 , B29C35/00 , B29D22/00 , B29C49/08 , B29C49/02 , A61F2/91 , B29C49/00 , B29C49/04 , B29C49/78 , B29L31/00
CPC分类号： B29D22/00 , A61F2/91 , B29C49/0005 , B29C49/02 , B29C49/04 , B29C49/08 , B29C49/78 , B29C55/26 , B29C2793/009 , B29K2995/004 , B29K2995/0041 , B29K2995/0046 , B29K2995/0056 , B29K2995/006 , B29K2995/0077 , B29K2995/0089 , B29L2031/7542
摘要： Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stem manufacture and fabrication of a stent therefrom are disclosed.
摘要翻译： 公开了扩展聚合物管的方法，其具有用于茎的制造和制造支架的所需或最佳形态和机械性能。
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公开(公告)号：US20140107762A1
公开(公告)日：2014-04-17
申请号：US13998199
申请日：2013-10-09
发明人： David C. Gale , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian , Anthony J. Abbate , Klaus Kleine , Stephen Schaible , Jonathan P. Durcan , Thierry Glauser , Bethany Steichen , James Oberhauser , Manish Gada , Lothar Kleiner , Mary Beth Kossuth , Yunbing Wang , Daniel Castro , David Wrolstad
IPC分类号： A61F2/90
CPC分类号： A61F2/90 , A61F2/82 , A61F2/91 , A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/9522 , A61L31/06 , A61L31/14 , B29C35/045 , B29C49/0005 , B29C49/14 , B29C49/4823 , B29C55/24 , B29C69/001 , B29C2049/0089 , B29C2793/0009 , B29K2067/00 , B29K2067/046 , B29K2105/258 , B29K2995/006 , B29L2031/7534 , C08L67/04
摘要： Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.
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公开(公告)号：US10709589B2
公开(公告)日：2020-07-14
申请号：US15590817
申请日：2017-05-09
发明人： Jana Buccola , Joel Harrington , Syed Hossainy , Mary Beth Kossuth , Annie Liu , James Oberhauser , Fuh-Wei Tang
摘要： A method of accelerated aging of bioresorbable polymer scaffolds including exposing the scaffold to water is disclosed. The scaffold is exposed to water at a controlled temperature for a selected aging time. The functional outputs, such as radial strength, expandability, and % recoil obtained from aged scaffolds predict those of real-time aging of the scaffold. The accelerated aging factor, which is the required shelf life divided by the aging time, is significantly higher for poly(L-lactide) scaffolds tested than thermal aging.
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8.发明申请BRANCHED POLYHYDROXYALKANOATE SYSTEMS FOR BIORESORBABLE VASCULAR SCAFFOLD APPLICATIONS 审中-公开用于生物可溶性血管松弛应用的分支聚羟基烷酸盐系统公开(公告)号：US20150305899A1
公开(公告)日：2015-10-29
申请号：US14261358
申请日：2014-04-24
IPC分类号： A61F2/856
CPC分类号： A61F2/915 , A61F2/958 , A61F2002/91575 , A61L31/06 , C08L67/04
摘要： An implantable medical devices such as a stent that includes sparse comb polyhydroxyalkanoate (PHA) systems is disclosed. The stent includes a stent body, scaffold, or substrate made partially or completely of polymer material including PHA.
摘要翻译： 公开了一种植入式医疗装置，例如包括稀疏梳聚羟基链烷酸酯（PHA）系统的支架。 支架包括支架主体，支架或由部分或完全由包括PHA的聚合物材料制成的基底。
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公开(公告)号：US20150290002A1
公开(公告)日：2015-10-15
申请号：US14250023
申请日：2014-04-10
CPC分类号： A61B5/4851 , A61B5/0066 , A61B5/0084 , A61B5/6852 , A61F2/91 , A61L29/146 , A61L29/18 , A61L31/146 , A61L31/18 , G01B9/02091 , H01L21/0337 , H01L21/31144
摘要： An endoprosthesis, a method for imaging an endoprosthesis, a method of making an endoprosthesis involve a polymeric substrate that has been modified to have voids embedded within the substrate. The voids are sized to scatter optical radiation from within the substrate so that an optical coherence tomography (OCT) image can be obtained in which an interior region of the substrate can be easily differentiated from empty space and other structures that surround the endoprosthesis. The voids allow for OCT visualization of the polymeric substrate which may be difficult to visualize by other methods such as fluoroscopy.
摘要翻译： 内置假体，用于成像内假体的方法，制造内假体的方法涉及已经被修改为具有嵌入衬底内的空隙的聚合物基底。 空隙的大小适于散射来自衬底内的光辐射，使得可以获得光学相干断层摄影（OCT）图像，其中衬底的内部区域可以容易地与空间和围绕内置假体的其他结构区分开。 空隙允许聚合物基底的OCT可视化，其可能难以通过诸如荧光透视的其它方法可视化。
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公开(公告)号：US20140114394A1
公开(公告)日：2014-04-24
申请号：US13998204
申请日：2013-10-09
发明人： David C. Gale , Bin Huang , Timothy A. Limon , Vincent J. Gueriguian , Anthony J. Abbate , Klaus Kleine , Stephen Schaible , Jonathan P. Durcan , Thierry Glauser , Bethany Steichen , James Oberhauser , Manish Gada , Lothar Kleiner , Mary Beth Kossuth , Yunbing Wang , Daniel Castro , David Wrolstad
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2002/9522 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , A61L31/06 , A61L31/14 , B29C35/045 , B29C49/0005 , B29C49/14 , B29C49/4823 , B29C55/24 , B29C69/001 , B29C2049/0089 , B29C2793/0009 , B29K2067/00 , B29K2067/046 , B29K2105/258 , B29K2995/006 , B29L2031/7534 , C08L67/04
摘要： Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed.
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