公开(公告)号：US20150231206A1

公开(公告)日：2015-08-20

申请号：US14626457

申请日：2015-02-19

Applicant: Amgen Inc.

Inventor： Jeonghoon Sun ,  Lei-Ting Tony Tam ,  Huiquan Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou ,  John Lu

IPC: A61K38/17 ,  A61K9/00 ,  A61K31/704

CPC classification number: A61K38/179 ,  A61K9/0019 ,  A61K31/513 ,  A61K31/655 ,  A61K31/704 ,  A61K38/177 ,  A61K38/193 ,  A61K38/2013 ,  A61K38/212 ,  A61K38/45 ,  A61K38/50 ,  C07K14/705 ,  C07K14/71 ,  C12Y305/01001 ,  A61K2300/00

Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.

Abstract translation: 本发明提供了能够结合和抑制活化素A，肌生成抑制素或GDF-11的活性的变体激活素IIB可溶性受体多肽和蛋白质。 本发明还提供能够产生变体多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦等疾病和病症的组合物和方法。

公开(公告)号：US20140243503A1

公开(公告)日：2014-08-28

申请号：US14134482

申请日：2013-12-19

Applicant: Amgen Inc.

Inventor： Edward John Belouski ,  Murielle Marie Ellison ,  Agnes Eav Hamburger ,  Randy Ira Hecht ,  Yue-Sheng Li ,  Mark Leo Michaels ,  Jeonghoon Sun ,  Jing Xu

IPC: C07K14/50 ,  C07K16/18

CPC classification number: C07K14/50 ,  A61K38/00 ,  A61K38/1825 ,  A61K2039/505 ,  C07K16/18 ,  C07K2319/30

Abstract: The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.

公开(公告)号：US20140194355A1

公开(公告)日：2014-07-10

申请号：US14204460

申请日：2014-03-11

Applicant: Amgen Inc.

Inventor： Jeonghoon Sun ,  Lei-Ting Tony Tam ,  Hui-Quan Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou

IPC: C07K14/71

CPC classification number: C07K14/71 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/30

Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.

Abstract translation: 本发明提供了能够结合和抑制活化素A，肌生成抑制素或GDF-11的活性的变体激活素IIB可溶性受体多肽和蛋白质。 本发明还提供能够产生变体多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦等疾病和病症的组合物和方法。