公开(公告)号：US20130288983A1

公开(公告)日：2013-10-31

申请号：US13932421

申请日：2013-07-01

Applicant: Amgen Inc.

Inventor： Jeonghoon Sun ,  Lei-Ting Tony Tam ,  Huiquan Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou ,  John Lu

IPC: C07K14/705 ,  A61K31/655 ,  A61K38/17 ,  A61K31/513

CPC classification number: C07K14/705 ,  A61K31/513 ,  A61K31/655 ,  A61K38/177 ,  A61K38/179 ,  A61K38/193 ,  A61K38/2013 ,  A61K38/212 ,  A61K38/45 ,  A61K38/50 ,  C07K14/71 ,  C12Y305/01001 ,  A61K2300/00

Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.

公开(公告)号：US08999917B2

公开(公告)日：2015-04-07

申请号：US13932421

申请日：2013-07-01

Applicant: Amgen Inc.

Inventor： Jeonghoon Sun ,  Lei-Ting Tony Tam ,  Huiquan Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou ,  John Lu

IPC: A61K38/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/71 ,  A61K38/45 ,  A61K31/513 ,  A61K31/655 ,  A61K38/17 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  A61K38/50

CPC classification number: C07K14/705 ,  A61K31/513 ,  A61K31/655 ,  A61K38/177 ,  A61K38/179 ,  A61K38/193 ,  A61K38/2013 ,  A61K38/212 ,  A61K38/45 ,  A61K38/50 ,  C07K14/71 ,  C12Y305/01001 ,  A61K2300/00

Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.

公开(公告)号：US20150231206A1

公开(公告)日：2015-08-20

申请号：US14626457

申请日：2015-02-19

Applicant: Amgen Inc.

Inventor： Jeonghoon Sun ,  Lei-Ting Tony Tam ,  Huiquan Han ,  Keith Soo-Nyung Kwak ,  Xiaolan Zhou ,  John Lu

IPC: A61K38/17 ,  A61K9/00 ,  A61K31/704

CPC classification number: A61K38/179 ,  A61K9/0019 ,  A61K31/513 ,  A61K31/655 ,  A61K31/704 ,  A61K38/177 ,  A61K38/193 ,  A61K38/2013 ,  A61K38/212 ,  A61K38/45 ,  A61K38/50 ,  C07K14/705 ,  C07K14/71 ,  C12Y305/01001 ,  A61K2300/00

Abstract: The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.

Abstract translation: 本发明提供了能够结合和抑制活化素A，肌生成抑制素或GDF-11的活性的变体激活素IIB可溶性受体多肽和蛋白质。 本发明还提供能够产生变体多肽和蛋白质的多核苷酸，载体和宿主细胞。 还提供了用于治疗肌肉消瘦等疾病和病症的组合物和方法。