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公开(公告)号：US20120149893A1
公开(公告)日：2012-06-14
申请号：US13267805
申请日：2011-10-06
申请人： Sanjay Bhanot , Kenneth W. Dobie , Ravi Jain
发明人： Sanjay Bhanot , Kenneth W. Dobie , Ravi Jain
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节eIF4E-BP2的表达。 组合物包含靶向编码eIF4E-BP2的核酸的寡核苷酸。 提供了使用这些化合物调节eIF4E-BP2表达和用于诊断和治疗与eIF4E-BP2表达相关的疾病和病症的方法。
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公开(公告)号：US08198253B2
公开(公告)日：2012-06-12
申请号：US12374635
申请日：2007-07-18
CPC分类号： C12N15/1135 , C12N2310/11
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of HBXIP in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译： 本文公开了用于调节细胞，组织或动物中HBXIP表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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33.发明授权公开(公告)号：US07981868B2
公开(公告)日：2011-07-19
申请号：US10568488
申请日：2004-08-12
CPC分类号： C12N15/1137 , A61K31/7052 , A61K38/00 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y207/11024 , Y02P20/582 , C12N2310/3525
摘要： Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for decreasing airway hyperresponsiveness or airway inflammation in an animal are also provided.
摘要翻译： 提供了用于治疗和诊断适于通过调节编码p38丝裂原活化蛋白激酶（p38MAPK）的基因的表达进行治疗的疾病或病症的组合物和方法。 还提供了降低动物气道高反应性或气道炎症的方法。
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公开(公告)号：US07902163B2
公开(公告)日：2011-03-08
申请号：US11449446
申请日：2006-06-07
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12Y115/01001 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of superoxide dismutase 1, soluble. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding superoxide dismutase 1, soluble. Methods of using these compounds for modulation of superoxide dismutase 1, soluble expression and for treatment of diseases associated with expression of superoxide dismutase 1, soluble are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节超氧化物歧化酶1的表达，可溶性。 组合物包含靶向编码超氧化物歧化酶1的核酸的可反应化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节超氧化物歧化酶1，可溶性表达和治疗与超氧化物歧化酶1表达相关的疾病的方法。
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公开(公告)号：US07759479B1
公开(公告)日：2010-07-20
申请号：US11226884
申请日：2005-09-13
申请人： Kenneth W. Dobie , Susan M. Freier
发明人： Kenneth W. Dobie , Susan M. Freier
CPC分类号： C12N15/113 , C07H21/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/342 , C12N2310/343 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of a Gemin Gene. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译： 本文公开了用于调节Gemin基因表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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公开(公告)号：US20090264502A1
公开(公告)日：2009-10-22
申请号：US12064330
申请日：2006-08-24
IPC分类号： A61K31/7125 , C07H21/02 , A61P35/00
CPC分类号： A61K48/00 , C12N15/113 , C12N2310/11 , C12N2310/321 , C12N2310/3341 , C12N2310/345 , C12N2310/3527
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of HSP27 in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.
摘要翻译： 本文公开了用于调节细胞，组织或动物中HSP27表达的化合物，组合物和方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。
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公开(公告)号：US20090203765A1
公开(公告)日：2009-08-13
申请号：US12094598
申请日：2006-11-21
申请人： Sanjay Bhanot , Kenneth W. Dobie , Ravi Jain
发明人： Sanjay Bhanot , Kenneth W. Dobie , Ravi Jain
IPC分类号： A61K31/7088 , A61P9/10 , A61K48/00
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of eIF4E-BP2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding eIF4E-BP2. Methods of using these compounds for modulation of eIF4E-BP2 expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E-BP2 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节eIF4E-BP2的表达。 组合物包含靶向编码eIF4E-BP2的核酸的寡核苷酸。 提供了使用这些化合物调节eIF4E-BP2表达和用于诊断和治疗与eIF4E-BP2表达相关的疾病和病症的方法。
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公开(公告)号：US20090156538A1
公开(公告)日：2009-06-18
申请号：US12262090
申请日：2008-10-30
申请人： Kenneth W. Dobie
发明人： Kenneth W. Dobie
IPC分类号： A61K31/7088 , A61K31/711 , A61K31/7105
CPC分类号： C07H21/00 , C07H21/04 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/01003 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of endothelial lipase. The compositions comprise oligonucleotides, targeted to nucleic acid encoding endothelial lipase. Methods of using these compounds for modulation of endothelial lipase expression and for diagnosis and treatment of disease associated with expression of endothelial lipase are provided.
摘要翻译： 提供化合物，组合物和方法用于调节内皮脂肪酶的表达。 组合物包含靶向编码内皮脂肪酶的核酸的寡核苷酸。 提供了使用这些化合物调节内皮脂肪酶表达和用于诊断和治疗与内皮脂肪酶表达相关的疾病的方法。
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公开(公告)号：US20090156526A1
公开(公告)日：2009-06-18
申请号：US12090847
申请日：2006-10-17
IPC分类号： A61K31/711 , C12Q1/68 , C12N5/00 , C07H21/04
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/11 , C12N2320/33
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of LMNA in a cell, tissue or animal. Also provided are methods of target validation. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Further provided are methods of identifying cis splicing regulatory elements of a selected mRNA using the disclosed compounds.
摘要翻译： 本文公开了用于调节细胞，组织或动物中LMNA表达的化合物，组合物和方法。 还提供了目标验证的方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。 还提供了使用所公开的化合物鉴定所选mRNA的顺式剪接调节元件的方法。
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公开(公告)号：US08642753B2
公开(公告)日：2014-02-04
申请号：US13566642
申请日：2012-08-03
申请人： Susan M. Freier , Kenneth W. Dobie , Robert McKay , Sanjay Bhanot
发明人： Susan M. Freier , Kenneth W. Dobie , Robert McKay , Sanjay Bhanot
IPC分类号： C07H21/04
CPC分类号： C12N15/1138 , C07K14/705 , C07K14/723 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of glucagon receptor. The compositions comprise oligonucleotides, targeted to nucleic acid encoding glucagon receptor. Methods of using these compounds for modulation of glucagon receptor expression and for diagnosis and treatment of disease associated with expression of glucagon receptor are provided.
摘要翻译： 提供化合物，组合物和方法用于调节胰高血糖素受体的表达。 组合物包含针对编码胰高血糖素受体的核酸的寡核苷酸。 提供了使用这些化合物调节胰高血糖素受体表达和用于诊断和治疗与胰高血糖素受体表达相关的疾病的方法。
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