公开(公告)号：US5200420A

公开(公告)日：1993-04-06

申请号：US677731

申请日：1991-03-29

Applicant: Siegfried Goldmann ,  Horst Boshagen ,  Jurgen Stoltefuss ,  Alexander Straub ,  Rainer Gross ,  Joachim Hutter ,  Siegbert Hebisch ,  Martin Bechem

Inventor： Siegfried Goldmann ,  Horst Boshagen ,  Jurgen Stoltefuss ,  Alexander Straub ,  Rainer Gross ,  Joachim Hutter ,  Siegbert Hebisch ,  Martin Bechem

IPC: A61K31/435 ,  A61K31/44 ,  A61P9/04 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07D263/56 ,  C07D263/57 ,  C07D277/66 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D491/04 ,  C07D491/048

CPC classification number: C07D263/57 ,  C07D277/66 ,  C07D413/04 ,  C07D417/04 ,  C07D491/04

Abstract: 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines which exhibit positive inotropic action with largely neutral vascular behavior, of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms,R.sup.2 represents nitro or cyano, orR.sup.1 and R.sup.2 together form a lactone ring of the formula ##STR2## R.sup.3 represents a radical of the formula ##STR3## R.sup.4 -R.sup.7 are defined hereinafter and physiologically acceptable salts thereof.

Abstract translation: 表现出具有大量中性血管行为的正性肌力作用的2,6-二烷基-4-（苯并噻唑基或苯并恶唑-7-基）-1,4-二氢吡啶，其中R1和R5是 相同或不同，代表具有至多8个碳原子的直链或支链烷基，R2代表硝基或氰基，或R1和R2一起形成下式的内酯环R3表示下式的基团： 下文定义R4-R7及其生理上可接受的盐。

公开(公告)号：US08530505B2

公开(公告)日：2013-09-10

申请号：US13360107

申请日：2012-01-27

Applicant: Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Röhrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

Inventor： Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Röhrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

IPC: A61K31/42 ,  C07D409/14

CPC classification number: C07D498/04 ,  A61K31/5377 ,  C07D333/38 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

Abstract: The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.

公开(公告)号：US20130005701A1

公开(公告)日：2013-01-03

申请号：US13360107

申请日：2012-01-27

Applicant: Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Röhrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

Inventor： Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Röhrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

IPC: A61K31/422 ,  A61K31/5377 ,  C07D417/14 ,  A61K31/541 ,  C07D495/04 ,  C12N5/078 ,  A61K31/428 ,  A61K31/496 ,  A61K31/444 ,  A61K31/454 ,  A61K31/538 ,  A61K31/5383 ,  C07D413/14 ,  A61K31/4365

CPC classification number: C07D498/04 ,  A61K31/5377 ,  C07D333/38 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

Abstract: The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.

公开(公告)号：US08129378B2

公开(公告)日：2012-03-06

申请号：US12494879

申请日：2009-06-30

Applicant: Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Röhrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

Inventor： Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Röhrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

IPC: A61K31/5377 ,  A61K31/42 ,  C07D409/14

CPC classification number: C07D498/04 ,  A61K31/5377 ,  C07D333/38 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

Abstract: The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.

Abstract translation: 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。

公开(公告)号：US08124786B2

公开(公告)日：2012-02-28

申请号：US12373218

申请日：2007-07-12

Applicant: Alexander Straub

Inventor： Alexander Straub

IPC: C07D231/00

CPC classification number: C07D231/14

Abstract: The present invention provides a metal-catalyzed process for preparation of substituted pyrazolecarboxamides of formula (I) as fungicidally active compounds from 2-alkylhaloaromatics and heterocyclylamides.

Abstract translation: 本发明提供一种金属催化的制备式（I）的取代的吡唑甲酰胺作为2-烷基卤代芳烃和杂环基酰胺的杀真菌活性化合物的方法。

公开(公告)号：US07926867B2

公开(公告)日：2011-04-19

申请号：US11950527

申请日：2007-12-05

Applicant: Stefan Kochert ,  Jochen Becker ,  Ralph Dalhaeuser ,  Andres Stiller ,  Alexander Straub ,  Thomas Hogger ,  Mark Riess ,  Josef Reindl ,  Juergen Kempf ,  Niklas Eberle ,  Robert Schalausky

Inventor： Stefan Kochert ,  Jochen Becker ,  Ralph Dalhaeuser ,  Andres Stiller ,  Alexander Straub ,  Thomas Hogger ,  Mark Riess ,  Josef Reindl ,  Juergen Kempf ,  Niklas Eberle ,  Robert Schalausky

IPC: B62D25/04

CPC classification number: B62D29/002

Abstract: A lengthwise extended component contains of a support that possesses flow channels in the direction of its longitudinal axis. The support additionally possesses external surfaces that are offset to each other in the direction of the longitudinal axis as well as a lateral external surface. These external surfaces are provided with a layer of a thermally expansible and curable composition. Reinforcing components of this type are suitable for stiffening and/or reinforcing hollow supports, such as the A-, B- or C-pillars, the roof edges or the rocker panels of vehicles, especially passenger cars.

Abstract translation: 纵向延伸部件包含在其纵向轴线方向上具有流动通道的支撑件。 支撑件还具有在纵向轴线方向上彼此偏移的外表面以及侧向外表面。 这些外表面设置有可热膨胀和可固化组合物的层。 这种类型的加强部件适用于加强和/或加强中空支撑件，例如A-，B-或C-支柱，车辆的车顶边缘或摇摆板，特别是乘用车。

公开(公告)号：US07576111B2

公开(公告)日：2009-08-18

申请号：US11932082

申请日：2007-10-31

Applicant: Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Rohrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

Inventor： Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Rohrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

IPC: A61K31/42 ,  C07D409/14

CPC classification number: C07D498/04 ,  A61K31/5377 ,  C07D333/38 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

Abstract: The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.

Abstract translation: 本发明涉及血液凝固领域。 描述了通式（I）的新型恶唑烷酮衍生物的制备及其作为用于预防和/或治疗病症的药物活性化合物的用途。

公开(公告)号：US20080090815A1

公开(公告)日：2008-04-17

申请号：US11932082

申请日：2007-10-31

Applicant: Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Rohrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

Inventor： Alexander Straub ,  Thomas Lampe ,  Jens Pohlmann ,  Susanne Rohrig ,  Elisabeth Perzborn ,  Karl-Heinz Schlemmer ,  Joseph Pernerstorfer

IPC: A61K31/541 ,  A61K31/421 ,  A61K31/4453 ,  A61P9/10 ,  C07D401/14 ,  C07D417/14 ,  C07D413/14 ,  C07D263/02 ,  A61P9/00 ,  A61K31/5355

CPC classification number: C07D498/04 ,  A61K31/5377 ,  C07D333/38 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D495/04

Abstract: The invention relates to the field of blood coagulation. Novel oxazolidinone derivatives of the general formula (I) processes for their preparation and their use as medicinally active compounds for the prophylaxis and/or treatment of disorders are described.

公开(公告)号：US07115599B2

公开(公告)日：2006-10-03

申请号：US10432572

申请日：2001-11-12

Applicant: Johannes-Peter Stasch ,  Achim Feurer ,  Stefan Weigand ,  Elke Stahl ,  Dietmar Flubacher ,  Cristina Alonso-Alija ,  Frank Wunder ,  Dieter Lang ,  Klaus Dembowsky ,  Alexander Straub ,  Elisabeth Perzborn

Inventor： Johannes-Peter Stasch ,  Achim Feurer ,  Stefan Weigand ,  Elke Stahl ,  Dietmar Flubacher ,  Cristina Alonso-Alija ,  Frank Wunder ,  Dieter Lang ,  Klaus Dembowsky ,  Alexander Straub ,  Elisabeth Perzborn

IPC: C07D471/04 ,  A61K31/437

CPC classification number: C07D471/04

Abstract: This invention relates to compounds of the formula in which R1, R2, and R3 are as defined in the claims, to a process for preparing such compounds, to pharmaceutical compositions containing such compounds, and to methods of using such compounds for treatment of hypertension and sexual dysfunction.

Abstract translation: 本发明涉及下式的化合物，其中R 1，R 2，R 3和R 3如权利要求中所定义， 用于制备这些化合物的药物组合物，以及使用这些化合物治疗高血压和性功能障碍的方法。

公开(公告)号：US20060004196A1

公开(公告)日：2006-01-05

申请号：US10518454

申请日：2003-06-20

Applicant: Alexander Straub

Inventor： Alexander Straub

IPC: C07D285/10 ,  C07D277/36

CPC classification number: C07D277/36

Abstract: The present invention relates to a process for preparing heterocyclic fluoroalkenyl sulfones and fluoroalkenyl sulfoxides by allowing the corresponding fluoroalkenyl thioethers to react with a salt of peroxomonosulfuric acid (H2SO5), optionally in the presence of a reaction assistant and optionally in the presence of a diluent.

Abstract translation: 本发明涉及一种通过使相应的氟代烯基硫醚与过氧硫酸（H 2 SO 3 H 5）的盐反应来制备杂环氟烯基砜和氟烯基亚砜的方法， 任选地在反应助剂的存在下和任选地在稀释剂存在下进行。