公开(公告)号：US20250090524A1

公开(公告)日：2025-03-20

申请号：US18709268

申请日：2022-11-11

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  BIn Ma ,  Jürgen Schulz ,  Marta Nevalainen ,  TeYu Chen ,  Robin J. Prince ,  Harold George Vandeveer ,  Issac Marx ,  Simone Sciaboba ,  Edward Yin Shiang Lin

IPC: A61K31/4985 ,  A61K31/437 ,  A61K31/55 ,  C07D471/04 ,  C07D487/04

Abstract: Provided are compounds of Formula (I) or pharmaceutically acceptable salts thereof, wherein the variables in Formula (I) are as defined herein; and methods for their use and production.

公开(公告)号：US12240838B2

公开(公告)日：2025-03-04

申请号：US17610963

申请日：2020-05-15

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Jürgen Schulz ,  Marta Nevalainen

IPC: C07D413/12 ,  C07D401/12 ,  C07D413/14 ,  C07D417/12

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US20250034150A1

公开(公告)日：2025-01-30

申请号：US18709273

申请日：2022-11-10

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Jürgen Schulz ,  Marta Nevalainen ,  TeYu Chen ,  Robin Prince ,  Harold George Vandeveer ,  Isaac Marx ,  Simone Sciabola ,  Zain Yousaf

IPC: C07D487/04 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  C07D471/04 ,  C07D519/00

Abstract: Provided are compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein the variables in Formula (I) are as defined herein; and methods for their use and production.

公开(公告)号：US20240327380A1

公开(公告)日：2024-10-03

申请号：US18019540

申请日：2021-08-05

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Isaac Marx ,  Jürgen Schulz ,  Harold George Vandeveer ,  Robin Prince ,  Marta Nevalainen ,  TeYu Chen ,  Zain Yousaf ,  Martin Himmelbauer ,  Vatee Pattaropong ,  John Howard Jones ,  Rab Gilfillan ,  Edward Yin Shiang Lin ,  Felix Gonzalez Lopez de Turiso ,  Bin Ma

IPC: C07D401/14 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D471/08 ,  C07D487/10

CPC classification number: C07D401/14 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D471/08 ,  C07D487/10

Abstract: Provided are compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m and n are as defined herein; pharmaceutical compositions comprising said compounds or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable excipients; and methods of treating a disorder responsive to inhibition of Bruton's tyrosine kinase using said compounds, or pharmaceutically acceptable salts thereof, or said pharmaceutical compositions.

公开(公告)号：US20240216330A1

公开(公告)日：2024-07-04

申请号：US18285123

申请日：2022-04-01

Applicant: BIOGEN MA INC.

Inventor： Michael Joseph Palte ,  Brian T. Hopkins ,  Matthew P. Scaramozza ,  Michael Christian Mingueneau ,  Alex Pellerin ,  Chelsea R. Parker Harp ,  Catherine Barbey

IPC: A61K31/4015 ,  A61K31/225 ,  A61K31/4545 ,  A61K31/4985 ,  A61K31/506 ,  A61P25/28 ,  A61P37/00

CPC classification number: A61K31/4015 ,  A61K31/225 ,  A61K31/4545 ,  A61K31/4985 ,  A61K31/506 ,  A61P25/28 ,  A61P37/00

Abstract: The present disclosure provides combination therapies for treating an autoimmune disease in a subject in need thereof. The methods comprise administering to the subject an effective amount of a BTK inhibitor in combination with an effective amount of a fumaric acid ester (FAE). The autoimmune disease can be treated include, for example, multiple sclerosis (MS), lupus, rheumatoid arthritis (RA), Pemphigus Vugaris (PV), neuromyelitis optica (NMO), myasthenia gravis (MG), chronic inflammatory demyelinating polyneuropathy (CIDP), anti-NMDA receptor encephalitis, or Sjogren's disease.

公开(公告)号：US20230121818A1

公开(公告)日：2023-04-20

申请号：US17788127

申请日：2020-12-23

Applicant: BIOGEN MA INC.

Inventor： Bin Ma ,  Brian T. Hopkins ,  Isaac Marx ,  Jürgen Schulz ,  George Vandeveer ,  Robin Prince ,  Marta Nevalainen ,  TeYu Chen ,  Zain Yousaf ,  Andrew George Capacci

IPC: C07D401/14 ,  C07D413/12 ,  C07D471/04 ,  C07D403/12 ,  C07D403/10 ,  C07D495/04 ,  C07D401/12 ,  C07D413/14

Abstract: Provided are compounds of Formula (I′) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R8, R9, R11A, R11B, R12, Ri, Rii, A1, A2, Q1, Q2, Q3, X, W, and n are as defined herein; pharmaceutical compositions comprising said compounds or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable excipients; and methods of treating a disorder responsive to inhibition of Bruton's tyrosine kinase using said compounds, or pharmaceutically acceptable salts thereof, or said pharmaceutical compositions.

公开(公告)号：US20230025892A1

公开(公告)日：2023-01-26

申请号：US17773418

申请日：2020-10-29

Applicant: BIOGEN MA INC.

Inventor： Isaac Marx ,  Jürgen Schulz ,  Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Marta Nevalainen

IPC: C07D487/04 ,  C07D519/00

Abstract: Provided are compounds of Formula (I): Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, A1, B1, B2, Q1 and Q2 are as defined herein; and methods for their use and production.

公开(公告)号：US11427577B2

公开(公告)日：2022-08-30

申请号：US17183702

申请日：2021-02-24

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Joseph P. Lyssikatos ,  Fengmei Zheng ,  Matthew Peterson ,  Daniel B. Patience

IPC: C07D417/14 ,  C07D403/14 ,  C07D413/14 ,  C07D405/14 ,  C07D471/04 ,  A61P43/00 ,  A61P1/16

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US20220259194A1

公开(公告)日：2022-08-18

申请号：US17610963

申请日：2020-05-15

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Bin Ma ,  Robin Prince ,  Isaac Marx ,  Jürgen Schulz ,  Marta Nevalainen

IPC: C07D413/12 ,  C07D413/14 ,  C07D401/12 ,  C07D417/12

Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.

公开(公告)号：US20220089592A1

公开(公告)日：2022-03-24

申请号：US17421348

申请日：2020-01-17

Applicant: BIOGEN MA INC.

Inventor： Brian T. Hopkins ,  Magnus Pfaffenbach ,  Tricia May-dracka ,  Ryan Evans ,  Fang Gao ,  Istvan Enyedy ,  Zhili Xin ,  Philippe Bolduc ,  Emily Anne Peterson

IPC: C07D471/04 ,  C07D519/00 ,  C07D487/04

Abstract: This invention relates to Imidazo[1,2-a]pyridinyl Derivatives of formula (I′), or pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, capable of modulating the activity of IRAK4. The invention further provides a method of manufacturing compounds of the invention, and methods for their therapeutic use. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including inflammatory disease, autoimmune disease, cancer, cardiovascular disease, a disease of the central nervous system, disease of the skin, an ophthalmic disease and condition, and a bone disease.