公开(公告)号：US20150045347A1

公开(公告)日：2015-02-12

申请号：US14371281

申请日：2013-01-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Dharmpal S. Dodd ,  Christopher P. Mussari ,  Rajeev S. Bhide ,  Satheesh Kesavan Nair ,  Venkatram Reddy Paidi ,  Sreekantha Ratna Kumar ,  Abhisek Banerjee ,  Ramesh Sistla ,  William J. Pitts ,  John Hynes

IPC: C07D471/10 ,  C07D417/14

CPC classification number: C07D471/10 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds having the following formula: (I) wherein: A is an optionally substituted triazole, or a stereoisomer or a pharmaceutically-acceptable salt thereof, are useful as kinase modulators, including IRAK-4 modulation.

Abstract translation: 具有下式的化合物：（I）其中：A是任选取代的三唑或其立体异构体或其药学上可接受的盐，可用作激酶调节剂，包括IRAK-4调节。

公开(公告)号：US20150011532A1

公开(公告)日：2015-01-08

申请号：US14371456

申请日：2013-01-11

Applicant: Bristol-Myers Squibb Company

Inventor： Venkatram Reddy Paidi ,  Sreekantha Ratna Kumar ,  Abhisek Banejee ,  Ramesh Sistla ,  Satheesh Kesavan Nair ,  William J. Pitts ,  John Hynes

IPC: C07D417/14 ,  C07D471/10

CPC classification number: C07D417/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04

Abstract: Compounds having the following formula: wherein A is, or; and X is N or C—R7, or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, are useful as kinase modulators, including IRAK-4 modulation.

Abstract translation: 具有下式的化合物：其中A是或; 并且X是N或C-R7，或其对映体，非对映体或其药学上可接受的盐，可用作激酶调节剂，包括IRAK-4调节。

公开(公告)号：USRE49931E1

公开(公告)日：2024-04-23

申请号：US17584147

申请日：2022-01-25

Applicant: Bristol-Myers Squibb Company

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Laxman Pasunoori ,  Sreekantha Ratna Kumar

IPC: A61K31/4196 ,  A61K31/437 ,  A61K31/4427 ,  A61K45/06 ,  C07D249/00 ,  C07D471/04

CPC classification number: A61K31/4196 ,  A61K31/437 ,  A61K31/4427 ,  A61K45/06 ,  C07D249/00 ,  C07D471/04

Abstract: Disclosed are compounds of Formula (I)




or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：USRE49880E1

公开(公告)日：2024-03-26

申请号：US17584139

申请日：2022-01-25

Applicant: Bristol-Myers Squibb Company

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  John E. Macor ,  Christopher P. Mussari ,  Laxman Pasunoori ,  Sreekantha Ratna Kumar ,  Trevor C. Sherwood ,  Ramesh Kumar Sistla

IPC: A61K31/4196 ,  A61K31/437 ,  A61K31/4427 ,  A61K45/06 ,  C07D249/00 ,  C07D471/04

CPC classification number: A61K31/4196 ,  A61K31/437 ,  A61K31/4427 ,  A61K45/06 ,  C07D249/00 ,  C07D471/04

Abstract: Disclosed are compounds of Formula (I)




or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US11820768B2

公开(公告)日：2023-11-21

申请号：US17245595

申请日：2021-04-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Trevor C. Sherwood ,  Brian K. Whiteley ,  John L. Gilmore ,  Sreekantha Ratna Kumar ,  Laxman Pasunoori ,  Pitani Veera Venkata Srinivas ,  Srinivasan Kunchithapatham Duraisamy ,  Subramanya Hegde ,  Rushith Kumar Anumula

IPC: C07D471/04 ,  A61K31/437 ,  C07D491/107 ,  C07D471/08 ,  A61P25/00 ,  A61P29/00 ,  A61P19/02 ,  C07D495/10 ,  C07D519/00 ,  A61P37/00

CPC classification number: C07D471/04 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P37/00 ,  C07D471/08 ,  C07D491/107 ,  C07D495/10 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (I)




N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US11672780B2

公开(公告)日：2023-06-13

申请号：US17113495

申请日：2020-12-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Tasir Shamsul Haque ,  Louis J. Lombardo ,  John E. Macor ,  Christopher P. Mussari ,  Laxman Pasunoori ,  Sreekantha Ratna Kumar ,  Trevor C. Sherwood ,  Shoshana L. Posy ,  Ramesh Kumar Sistla ,  Subramanya Hegde ,  Anupama Kandhi Ramachandra Reddy

IPC: A61K31/4196 ,  A61K31/437 ,  A61K31/4427 ,  A61K45/06 ,  C07D471/04 ,  C07D249/00

CPC classification number: A61K31/4196 ,  A61K31/437 ,  A61K31/4427 ,  A61K45/06 ,  C07D249/00 ,  C07D471/04

Abstract: Disclosed are compounds of Formula (I)




or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20230117470A1

公开(公告)日：2023-04-20

申请号：US17773425

申请日：2020-10-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Laxman Pasunoori ,  Sreekantha Ratna Kumar ,  Pitani Veera Venkata Srinivas ,  Vikram Bhogadi ,  Duraisamy Kunchithapatham Srinivasan ,  Anupama Kandhi Ramachandra Reddy ,  Rushith Kumar Anumula ,  Alaric J. Dyckman

IPC: C07D471/04 ,  C07D519/00 ,  C07D417/14

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US11299501B2

公开(公告)日：2022-04-12

申请号：US16955108

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Brian K. Whiteley ,  Sreekantha Ratna Kumar ,  Anupama Kandhi Ramachandra Reddy

IPC: C07D519/00 ,  C07D487/04

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, X, Y, Z, R1, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US11053244B1

公开(公告)日：2021-07-06

申请号：US16910101

申请日：2020-06-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Trevor C. Sherwood ,  Brian K. Whiteley ,  John L. Gilmore ,  Sreekantha Ratna Kumar ,  Laxman Pasunoori ,  Pitani Veera Venkata Srinivas ,  Srinivasan Kunchithapatham Duraisamy ,  Subramanya Hegde ,  Rushith Kumar Anumula

IPC: C07D471/04 ,  A61K31/437 ,  C07D491/107 ,  C07D471/08 ,  A61P25/00 ,  A61P37/00 ,  A61P19/02 ,  C07D495/10 ,  C07D519/00 ,  A61P29/00

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US10730877B2

公开(公告)日：2020-08-04

申请号：US16695303

申请日：2019-11-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Trevor C. Sherwood ,  Brian K. Whiteley ,  John L. Gilmore ,  Sreekantha Ratna Kumar ,  Laxman Pasunoori ,  Pitani Veera Venkata Srinivas ,  Srinivasan Kunchithapatham Duraisamy ,  Subramanya Hegde ,  Rushith Kumar Anumula

IPC: C07D471/04 ,  A61K31/437 ,  C07D491/107 ,  C07D471/08 ,  A61P25/00 ,  A61P37/00 ,  A61P19/02 ,  C07D495/10 ,  C07D519/00 ,  A61P29/00

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.