公开(公告)号：US11008306B2

公开(公告)日：2021-05-18

申请号：US16864825

申请日：2020-05-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James A. Johnson ,  John Lloyd ,  Heather Finlay ,  James Neels ,  Naveen Kumar Dhondi ,  Prashantha Gunaga ,  Abhisek Banerjee ,  Ashokkumar Adisechan

IPC: C07D401/14 ,  C07D239/95 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/549 ,  A61K45/06 ,  C07D239/94 ,  C07D405/12 ,  C07D471/04 ,  C07D513/04

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

公开(公告)号：US08987311B2

公开(公告)日：2015-03-24

申请号：US14371281

申请日：2013-01-11

Applicant: Bristol-Myers Squibb Company

Inventor： Dharmpal S. Dodd ,  Christopher P. Mussari ,  Rajeev S. Bhide ,  Satheesh Kesavan Nair ,  Venkatram Reddy Paidi ,  Sreekantha Ratna Kumar ,  Abhisek Banerjee ,  Ramesh Sistla ,  William J. Pitts ,  John Hynes

IPC: C07D401/04 ,  A61K31/44 ,  C07D471/10 ,  C07D417/14

CPC classification number: C07D471/10 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds having the following formula: (I) wherein: A is an optionally substituted triazole, or a stereoisomer or a pharmaceutically-acceptable salt thereof, are useful as kinase modulators, including IRAK-4 modulation.

Abstract translation: 具有下式的化合物：（I）其中：A是任选取代的三唑或其立体异构体或其药学上可接受的盐，可用作激酶调节剂，包括IRAK-4调节。

公开(公告)号：US20220324836A1

公开(公告)日：2022-10-13

申请号：US17231088

申请日：2021-04-15

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James A. Johnson ,  John Lloyd ,  Heather Finlay ,  James Neels ,  Naveen Kumar Dhondi ,  Prashantha Gunaga ,  Abhisek Banerjee ,  Ashokkumar Adisechan

IPC: C07D401/14 ,  C07D239/95 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/549 ,  A61K45/06 ,  C07D239/94 ,  C07D405/12 ,  C07D471/04 ,  C07D513/04

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

公开(公告)号：US20180072712A1

公开(公告)日：2018-03-15

申请号：US15818826

申请日：2017-11-21

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Venkatram Reddy Paidi ,  Sreekantha Ratna Kumar ,  Abhisek Banerjee ,  Ramesh Sistla ,  Satheesh Kesavan Nair ,  William J. Pitts ,  John Hynes

IPC: C07D417/14 ,  C07D487/04 ,  C07D471/04 ,  C07D413/14 ,  C07D417/04 ,  C07D413/04

CPC classification number: C07D417/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds having the following formula: or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein X is N or C—R7, are useful as kinase modulators, including IRAK-4 modulation.

公开(公告)号：US09242975B2

公开(公告)日：2016-01-26

申请号：US14371456

申请日：2013-01-11

Applicant: Bristol-Myers Squibb Company

Inventor： Venkatram Reddy Paidi ,  Sreekantha Ratna Kumar ,  Abhisek Banerjee ,  Ramesh Sistla ,  Satheesh Kesavan Nair ,  William J. Pitts ,  John Hynes

IPC: C07D417/14 ,  C07D413/14 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04

CPC classification number: C07D417/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04

Abstract: Compounds having the following formula: wherein A is, or; and X is N or C—R7, or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, are useful as kinase modulators, including IRAK-4 modulation.

Abstract translation: 具有下式的化合物：其中A是或; 并且X是N或C-R7，或其对映体，非对映体或其药学上可接受的盐，可用作激酶调节剂，包括IRAK-4调节。

公开(公告)号：US20230322726A1

公开(公告)日：2023-10-12

申请号：US18125826

申请日：2023-03-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James A. Johnson ,  John Lloyd ,  Heather Finlay ,  James Neels ,  Naveen Kumar Dhondi ,  Prashantha Gunaga ,  Abhisek Banerjee ,  Ashokkumar Adisechan

IPC: C07D401/14 ,  C07D239/95 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/549 ,  A61K45/06 ,  C07D239/94 ,  C07D405/12 ,  C07D471/04 ,  C07D513/04

CPC classification number: C07D401/14 ,  A61K31/517 ,  A61K31/549 ,  A61K31/5377 ,  A61K45/06 ,  C07D239/94 ,  C07D239/95 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D513/04

Abstract: A compound of formula I





wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

公开(公告)号：US10227340B2

公开(公告)日：2019-03-12

申请号：US15818826

申请日：2017-11-21

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Venkatram Reddy Paidi ,  Sreekantha Ratna Kumar ,  Abhisek Banerjee ,  Ramesh Kumar Sistla ,  Satheesh Kesavan Nair ,  William J. Pitts ,  John Hynes

IPC: C07D417/14 ,  C07D413/14 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds having the following formula: or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein X is N or C—R7, are useful as kinase modulators, including IRAK-4 modulation.

公开(公告)号：US20160083375A1

公开(公告)日：2016-03-24

申请号：US14960785

申请日：2015-12-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： VENKATRAM REDDY PAIDI ,  Sreekantha Ratna Kumar ,  Abhisek Banerjee ,  Ramesh Sistla ,  Satheesh Kesavan Nair ,  William J. Pitts ,  John Hynes

IPC: C07D417/14

CPC classification number: C07D417/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds having the following formula: or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein X is N or C—R7, are useful as kinase modulators, including IRAK-4 modulation.

Abstract translation: 具有下式的化合物或其对映体，非对映异构体或其药学上可接受的盐，其中X为N或C-R7，可用作激酶调节剂，包括IRAK-4调节。

公开(公告)号：US20150045347A1

公开(公告)日：2015-02-12

申请号：US14371281

申请日：2013-01-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Dharmpal S. Dodd ,  Christopher P. Mussari ,  Rajeev S. Bhide ,  Satheesh Kesavan Nair ,  Venkatram Reddy Paidi ,  Sreekantha Ratna Kumar ,  Abhisek Banerjee ,  Ramesh Sistla ,  William J. Pitts ,  John Hynes

IPC: C07D471/10 ,  C07D417/14

CPC classification number: C07D471/10 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds having the following formula: (I) wherein: A is an optionally substituted triazole, or a stereoisomer or a pharmaceutically-acceptable salt thereof, are useful as kinase modulators, including IRAK-4 modulation.

Abstract translation: 具有下式的化合物：（I）其中：A是任选取代的三唑或其立体异构体或其药学上可接受的盐，可用作激酶调节剂，包括IRAK-4调节。

公开(公告)号：US20200255407A1

公开(公告)日：2020-08-13

申请号：US16864825

申请日：2020-05-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James A. Johnson ,  John Lloyd ,  Heather Finlay ,  James Neels ,  Naveen Kumar Dhondi ,  Prashantha Gunaga ,  Abhisek Banerjee ,  Ashokkumar Adisechan

IPC: C07D401/14 ,  C07D513/04 ,  C07D471/04 ,  C07D405/12 ,  C07D239/94 ,  A61K45/06 ,  A61K31/549 ,  A61K31/5377 ,  A61K31/517 ,  C07D417/14 ,  C07D417/12 ,  C07D413/14 ,  C07D407/12 ,  C07D403/12 ,  C07D403/04 ,  C07D401/12 ,  C07D239/95

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.