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    DNA encoding a galanin receptor
    32.
    发明授权
    DNA encoding a galanin receptor 失效
    编码甘丙肽受体的DNA

    公开(公告)号：US06399325B1

    公开(公告)日：2002-06-04

    申请号：US08540650

    申请日：1995-10-11

    申请人： Shuji Hinuma ,  Ryo Fujii ,  Shoji Fukusumi ,  Tetsuya Ohtaki ,  Masaki Hosoya ,  Kazuhiro Ohgi ,  Haruo Onda

    发明人： Shuji Hinuma ,  Ryo Fujii ,  Shoji Fukusumi ,  Tetsuya Ohtaki ,  Masaki Hosoya ,  Kazuhiro Ohgi ,  Haruo Onda

    IPC分类号： C12N1512

    CPC分类号： C07K14/723

    摘要： Galanin receptor proteins, production and use thereof including screening of galanin receptor agonists and antagonists are provided. Galanin receptor proteins, etc. or salts thereof, partial peptides thereof, DNAs coding for the above galanin receptor protein, processes for producing the above receptor protein, methods of screening for a galanin receptor agonist and/or antagonist or screening kits therefor, agonist and/or antagonist compounds or salts thereof obtained by the above screening method or the screening kit, pharmaceutical compositions containing the above compound or its salt, and antibodies against the above receptor protein are provided. It is allowable to efficiently screen a galanin receptor agonist or antagonist by using the galanin receptor protein, the partial peptide thereof, the galanin receptor protein-encoding DNA, the receptor protein-containing cell or its membrane fraction. The pharmaceuticals thus screened or characterized permits various applications including prophylactic and/or therapeutic treatments against a variety of diseases, e.g., stomach ulcer, diabetes, Alzheimer's disease, dementia, etc. and a sedative.

    摘要翻译： 提供了Galanin受体蛋白质，其生产和使用，包括甘露糖素受体激动剂和拮抗剂的筛选。 加兰林素受体蛋白等或其盐，其部分肽，编码上述甘丙肽受体蛋白质的DNA，产生上述受体蛋白质的方法，筛选甘丙肽受体激动剂和/或拮抗剂的方法或其筛选试剂盒，激动剂和 /或通过上述筛选方法获得的拮抗剂化合物或其盐或筛选试剂盒，含有上述化合物或其盐的药物组合物和抗上述受体蛋白的抗体。 可以通过使用甘丙肽受体蛋白，其部分肽，编码甘露糖素受体蛋白的DNA，含受体蛋白的细胞或其膜部分来有效筛选甘丙肽受体激动剂或拮抗剂。 如此筛选或表征的药物允许各种应用，包括针对各种疾病（例如胃溃疡，糖尿病，阿尔茨海默病，痴呆等）和镇静剂的预防和/或治疗性治疗。