利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

36 条记录 (耗时 0.036 秒)

    Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use
    36.
    发明申请
    Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use 有权
    垂体腺苷酸环化酶活化肽（PACAP）受体3（R3）激动剂及其药理学用途

    公开(公告)号：US20050043237A1

    公开(公告)日：2005-02-24

    申请号：US10892981

    申请日：2004-07-15

    申请人： Clark Pan ,  Manami Tsutsumi ,  Armen Shanafelt

    发明人： Clark Pan ,  Manami Tsutsumi ,  Armen Shanafelt

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/575 ,  C07K14/705 ,  A61K38/17 ,  C07H21/04

    CPC分类号： C07K14/575 ,  A61K38/00 ,  A61K48/00

    摘要： This invention provides novel peptides that function in vivo to stimulate insulin release from pancreatic beta cells in a glucose-dependent fashion. These insulin secretagogue peptides are shown to stimulate insulin release in rat islet cells in vitro, and in vivo. The peptides of the present invention provide a new therapy for patients with decreased endogenous insulin secretion, in particular type 2 diabetics. In particular, the invention is a polypeptide selected from a specific group of VIP/PACAP-related polypeptides, or functional equivalents thereof. The invention is also directed to a method of treating a metabolic disease in a mammal comprising administering a therapeutically effective amount of the insulin secretagogue peptides to said mammal. Also disclosed are methods of making the peptides, both recombinant and synthetic.

    摘要翻译： 本发明提供了新的肽，其在体内起作用以以葡萄糖依赖的方式刺激胰腺β细胞的胰岛素释放。 这些胰岛素促分泌肽显示能够在体外和体内刺激大鼠胰岛细胞中的胰岛素释放。 本发明的肽为具有降低的内源性胰岛素分泌的患者特别是2型糖尿病患者提供了新的疗法。 特别地，本发明是选自VIP / PACAP相关多肽的特定组的多肽或其功能等同物。 本发明还涉及一种治疗哺乳动物代谢疾病的方法，包括向所述哺乳动物施用治疗有效量的胰岛素促分泌肽。 还公开了制备重组体和合成肽的方法。