专利检索 ap:("Clark Pan" OR "James Whelan" OR "Kevin Clairmont") AND inv:"Kevin Clairmont" 第 1 页

1.

发明申请
Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use 失效

公开(公告)号：US20050288248A1

公开(公告)日：2005-12-29

申请号：US11212439

申请日：2005-08-26

申请人： Clark Pan , James Whelan , Kevin Clairmont

发明人： Clark Pan , James Whelan , Kevin Clairmont

IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K38/22 , A61K48/00 , A61P3/00 , A61P3/04 , A61P3/08 , A61P3/10 , A61P43/00 , C07K14/47 , C07K14/575 , C07K14/605 , C07K14/745 , C07K16/00 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/00 , C12P21/02 , C07H21/04 , C07K14/705 , C12Q1/68

CPC分类号： C07K14/605 , A61K38/00

摘要： The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.

2.

发明申请
Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use 失效

公开(公告)号：US20050153890A1

公开(公告)日：2005-07-14

申请号：US10999622

申请日：2004-11-29

申请人： Clark Pan , James Whelan , Kevin Clairmont

发明人： Clark Pan , James Whelan , Kevin Clairmont

IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K38/22 , A61K48/00 , A61P3/00 , A61P3/04 , A61P3/08 , A61P3/10 , A61P43/00 , C07K14/47 , C07K14/575 , C07K14/605 , C07K14/745 , C07K16/00 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/00 , C12P21/02 , A61K38/17 , C07H21/04 , C07K14/72 , C07K16/28

CPC分类号： C07K14/605 , A61K38/00

摘要： The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.

3.

发明申请
Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use 失效

公开(公告)号：US20060003934A1

公开(公告)日：2006-01-05

申请号：US11213023

申请日：2005-08-26

申请人： Clark Pan , James Whelan , Kevin Clairmont

发明人： Clark Pan , James Whelan , Kevin Clairmont

IPC分类号： A61K38/17 , C07H21/04 , C12P21/06 , C07K14/47 , C07K16/18

CPC分类号： C07K14/605 , A61K38/00

摘要： The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.

4.

发明申请
Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use 审中-公开

公开(公告)号：US20060003935A1

公开(公告)日：2006-01-05

申请号：US11213024

申请日：2005-08-26

申请人： Clark Pan , James Whelan , Kevin Clairmont

发明人： Clark Pan , James Whelan , Kevin Clairmont

IPC分类号： A61K38/17

CPC分类号： C07K14/605 , A61K38/1709 , A61K38/26

摘要： The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.

5.

发明申请
Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use 审中-公开

公开(公告)号：US20060003418A1

公开(公告)日：2006-01-05

申请号：US11213083

申请日：2005-08-26

申请人： Clark Pan , James Whelan , Kevin Clairmont

发明人： Clark Pan , James Whelan , Kevin Clairmont

IPC分类号： A61K38/17 , A61K48/00 , C07K14/47 , C07K16/18

CPC分类号： C07K14/605 , A61K38/00

摘要： The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.

6.

发明申请
Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use 失效

公开(公告)号：US20060003419A1

公开(公告)日：2006-01-05

申请号：US11213087

申请日：2005-08-26

申请人： Clark Pan , James Whelan , Kevin Clairmont

发明人： Clark Pan , James Whelan , Kevin Clairmont

IPC分类号： A61K38/17 , A61K48/00 , C07K14/47 , C07K16/18 , C07H21/04 , C12P21/06

CPC分类号： C07K14/605 , A61K38/00

摘要： The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.

7.

发明申请
Peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists and their pharmacological methods of use 失效

公开(公告)号：US20060003417A1

公开(公告)日：2006-01-05

申请号：US11213026

申请日：2005-08-26

申请人： Clark Pan , James Whelan , Kevin Clairmont

发明人： Clark Pan , James Whelan , Kevin Clairmont

IPC分类号： A61K38/17 , A61K48/00 , C07K14/47 , C07K16/18

CPC分类号： C07K14/605 , A61K38/00

摘要： The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.

8.

发明申请
Pituitary adenylate cyclase acivating peptide (pacap) receptor (vpac2) agonists and their pharmacological methods of use 审中-公开
标题翻译：垂体腺苷酸环化酶激活肽（pacap）受体（vpac2）激动剂及其药理学用途

公开(公告)号：US20090280106A1

公开(公告)日：2009-11-12

申请号：US11919819

申请日：2006-04-18

申请人： Kevin Clairmont , James Whelan , Kevin Lumb

发明人： Kevin Clairmont , James Whelan , Kevin Lumb

IPC分类号： A61K38/48 , C07K14/435 , C07H21/04 , C12N15/63 , C12N5/00 , C12P21/06 , C07K16/18 , A61K38/16 , A61K38/28 , A61K38/46

CPC分类号： C07K14/57563 , A61K38/00

摘要： This invention provides peptides with novel modifications that provide suitable derivatization sites to improve the pharmacokinetic properties of the peptides. These modified peptides function in vivo as agonists of the VPAC2 receptor. The peptides of the present invention provide a new therapy for patients with decreased endogenous insulin secretion, for example, type 2 diabetics.

摘要翻译： 本发明提供了具有提供合适的衍生位点以改进肽的药代动力学性质的新型修饰的肽。这些修饰的肽在体内作为VPAC2受体的激动剂发挥作用。本发明的肽为内分泌胰岛素分泌降低的患者提供了新的疗法，例如2型糖尿病患者。

9.

发明授权
Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof 有权
标题翻译：双环乙酰辅酶A羧化酶抑制剂及其用途

公开(公告)号：US08697739B2

公开(公告)日：2014-04-15

申请号：US13189760

申请日：2011-07-25

申请人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Liansheng Su

发明人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Liansheng Su

IPC分类号： C07D215/00 , C07D235/04 , A61K31/4985 , A61K31/47

CPC分类号： A61K31/542 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/1075 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D215/36 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/30 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D471/04 , C07D513/04 , C12N9/93 , C12Y604/01002

摘要： The present invention provides compounds of formula (I); or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (I), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.

摘要翻译： 本发明提供式（I）化合物; 或其药学上可接受的盐，其中变量如本文所定义。本发明提供了制备式（I）化合物，其治疗用途，与其他药理学活性剂的组合以及药物组合物的方法。

10.

发明授权
Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof 有权

公开(公告)号：US09789118B2

公开(公告)日：2017-10-17

申请号：US14188647

申请日：2014-02-24

申请人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon, II , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Su Liansheng

发明人： David Weninger Barnes , Gregory Raymond Bebernitz , Kevin Clairmont , Scott Louis Cohen , Robert Edson Damon, II , Robert Francis Day , Stephanie Kay Dodd , Christoph Gaul , Hatice Belgin Gulgeze Efthymiou , Monish Jain , Rajeshri Ganesh Karki , Louise Clare Kirman , Kai Lin , Justin Yik Ching Mao , Tajesh Jayprakash Patel , Brian Kenneth Raymer , Su Liansheng

IPC分类号： C07D215/36 , C07D235/18 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D413/12 , C07D471/04 , C07D513/04 , A61K31/542 , A61K31/4184 , A61K9/00 , A61K9/08 , A61K9/107 , C12N9/00 , A61K31/404 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/30 , C07D405/14

CPC分类号： A61K31/542 , A61K9/0014 , A61K9/0019 , A61K9/0095 , A61K9/08 , A61K9/1075 , A61K31/404 , A61K31/4184 , A61K31/423 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/24 , C07D215/36 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/18 , C07D235/30 , C07D263/57 , C07D401/04 , C07D401/12 , C07D403/04 , C07D405/04 , C07D405/14 , C07D413/12 , C07D471/04 , C07D513/04 , C12N9/93 , C12Y604/01002

摘要： The present invention provides compounds of formula (IV); or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (IV), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.