利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

19 条记录 (耗时 0.064 秒)

    Pituitary adenylate cyclase activating peptide (PACAP) receptor (VPAC2) agonists and their pharmacological methods of use
    1.
    发明申请
    Pituitary adenylate cyclase activating peptide (PACAP) receptor (VPAC2) agonists and their pharmacological methods of use 审中-公开
    垂体腺苷酸环化酶激活肽（PACAP）受体（VPAC2）激动剂及其药理学用途

    公开(公告)号：US20090258826A1

    公开(公告)日：2009-10-15

    申请号：US12154468

    申请日：2008-05-23

    申请人： Wayne A. Froland ,  Drew N. Kelner ,  Michael L. Dumas ,  Clark Pan ,  James Whelan ,  Yu-chang John Wang ,  Wei Wang

    发明人： Wayne A. Froland ,  Drew N. Kelner ,  Michael L. Dumas ,  Clark Pan ,  James Whelan ,  Yu-chang John Wang ,  Wei Wang

    IPC分类号： A61K38/17 ,  C07K14/47 ,  C07H21/00 ,  C12N15/63 ,  C12N5/10 ,  C12P21/02 ,  C07K16/18 ,  A61P3/10 ,  A61K31/711

    CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K14/57563

    摘要： This invention provides novel peptides that function in vivo as agonists of the VPAC2 receptor. These insulin secretagogue polypeptides are shown to lower blood glucose in vivo more than controls upon glucose challenge. The polypeptides of this invention are also stable in formulation and have long half-lives. The peptides of the present invention provide a new therapy for patients with decreased endogenous insulin secretion, in particular type 2 diabetics. In particular, the invention is a polypeptide selected from a specific group of VPAC2-related polypeptides, or functional equivalents thereof. The invention is also directed to a method of treating a metabolic disease in a mammal comprising administering a therapeutically effective amount of the insulin secretagogue peptides to said mammal. Also disclosed are methods of making the peptides, both recombinant and synthetic.

    摘要翻译： 本发明提供了在体内作为VPAC2受体的激动剂起作用的新型肽。 显示这些胰岛素促分泌素多肽比葡萄糖攻击时的对照降低体内血糖。 本发明的多肽在制剂中也是稳定的并且具有长的半衰期。 本发明的肽为具有降低的内源性胰岛素分泌的患者特别是2型糖尿病患者提供了新的疗法。 特别地，本发明是选自VPAC2相关多肽的特定组的多肽或其功能等同物。 本发明还涉及一种治疗哺乳动物代谢疾病的方法，包括向所述哺乳动物施用治疗有效量的胰岛素促分泌肽。 还公开了制备重组体和合成肽的方法。

    Radio frequency identification (RFID) test information control and tracking system
    6.
    发明申请
    Radio frequency identification (RFID) test information control and tracking system 失效
    射频识别（RFID）测试信息控制和跟踪系统

    公开(公告)号：US20050009122A1

    公开(公告)日：2005-01-13

    申请号：US10887433

    申请日：2004-07-08

    申请人： James Whelan ,  C. Hanbury

    发明人： James Whelan ,  C. Hanbury

    IPC分类号： B01L3/00 ,  G01N33/569 ,  G01N35/00

    CPC分类号： G01N35/00732 ,  B01L3/5023 ,  B01L3/5085 ,  B01L3/545 ,  B01L2300/022 ,  B01L2300/024 ,  B01L2300/0825 ,  B01L2300/0829 ,  G01N2035/00782

    摘要： In one embodiment, a system for analytical testing comprises a test cartridge for use in conducting an analytical test including a test medium and an RFID device. An encoding device is provided adapted to preprogram the RFID with information relating to the test. An analytical detection device including a RFID transceiver adapted to transfer data to and from the RFID device is coupled to test detection instrumentation adapted to analyze the test medium in response to the information relating to the test.

    摘要翻译： 在一个实施例中，用于分析测试的系统包括用于进行包括测试介质和RFID设备的分析测试的测试盒。 提供了一种编码装置，其适于使用与测试相关的信息对RFID进行预编程。 包括适于向RFID设备传送数据的RFID收发器的分析检测装置耦合到适于根据与测试相关的信息分析测试介质的测试检测仪器。