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72 条记录 (耗时 0.056 秒)

    Method of making a tissue shaping device
    32.
    发明授权
    Method of making a tissue shaping device 有权
    制作组织整形装置的方法

    公开(公告)号：US07814635B2

    公开(公告)日：2010-10-19

    申请号：US11383115

    申请日：2006-05-12

    申请人： Lucas Gordon ,  Mark L. Mathis ,  Nathan Aronson

    发明人： Lucas Gordon ,  Mark L. Mathis ,  Nathan Aronson

    IPC分类号： B23P11/00 ,  A61F2/24

    CPC分类号： A61F2/2451 ,  Y10T29/49609 ,  Y10T29/49826 ,  Y10T29/49947 ,  Y10T29/49995

    摘要： A tissue shaping device adapted to be deployed in a vessel to reshape tissue adjacent to the vessel. In some embodiments the device includes first and second anchors and a connector disposed between the first and second anchors, with the connector being integral with at least a portion of the first anchor. The invention is also a method of making a tissue shaping device including the steps of removing material from a blank to form a connector and an integral anchor portion; and attaching a non-integral anchor portion to the integral anchor portion.

    摘要翻译： 一种组织成形装置，其适于部署在容器中以重塑邻近容器的组织。 在一些实施例中，该装置包括第一和第二锚定器以及设置在第一和第二锚固件之间的连接器，其中连接器与第一锚固件的至少一部分成一体。 本发明还是一种制造组织成形装置的方法，包括以下步骤：从坯料上去除材料以形成连接器和一体的锚定部分; 以及将非整体锚定部分附接到所述整体锚定部分。

    Mitral valve device using conditioned shape memory alloy
    33.
    发明授权
    Mitral valve device using conditioned shape memory alloy 有权
    二尖瓣装置采用条状形状记忆合金

    公开(公告)号：US07758639B2

    公开(公告)日：2010-07-20

    申请号：US11655710

    申请日：2007-01-18

    申请人： Mark L. Mathis

    发明人： Mark L. Mathis

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2451 ,  A61F2210/0023

    摘要： A mitral valve annulus reshaping device includes at least a portion that is formed of a biocompatible shape memory alloy SMA having a characteristic temperature, Af, that is preferably below body temperature. The device is constrained in an unstable martensite (UM) state while being introduced through a catheter that passes through the venous system and into the coronary sinus of the heart. The reshaping device is deployed adjacent to the mitral valve annulus of the heart as it is forced from the catheter. When released from the constraint of the catheter, the SMA of the device at least partially converts from the UM state to an austenitic state and attempts to change to a programmed shape that exerts a force on the adjacent tissue and modifies the shape of the annulus. The strain of the SMA can be varied when the device is within the coronary sinus.

    摘要翻译： 二尖瓣环重塑装置至少包括由具有特征温度Af的生物相容性形状记忆合金SMA形成的部分，其优选低于体温。 该装置被限制在不稳定的马氏体（UM）状态，同时通过导管穿过静脉系统并进入心脏的冠状窦。 当从导管被迫时，整形装置邻近心脏的二尖瓣环部署。 当从导管的约束释放时，该装置的SMA至少部分地从UM状态转变为奥氏体状态，并尝试改变为在相邻组织上施加力并且修改环形的形状的编程形状。 当器件在冠状窦内时，SMA的应变可以变化。

    Devices and Methods for Perfusing an Organ
    34.
    发明申请
    Devices and Methods for Perfusing an Organ 审中-公开
    用于灌注器官的装置和方法

    公开(公告)号：US20090018526A1

    公开(公告)日：2009-01-15

    申请号：US11996416

    申请日：2006-08-25

    申请人： John Melmouth Power ,  Mark L. Mathis ,  David Martin Kaye ,  Adam Lucas Bilney

    发明人： John Melmouth Power ,  Mark L. Mathis ,  David Martin Kaye ,  Adam Lucas Bilney

    IPC分类号： A61M25/01 ,  A61F2/84

    CPC分类号： A61M25/01 ,  A61F2/82 ,  A61M25/09 ,  A61M25/10 ,  A61M29/02 ,  A61M2025/09183 ,  A61M2025/1052

    摘要： The present invention provides devices and methods for use in the perfusion of organs and anatomical regions. In one aspect the present method provides a percutaneously deliverable device for supporting a vessel in a human or animal subject including means for supporting the vessel during delivery of a fluid thereto or collection of a fluid therefrom. In another aspect the invention provides a method for delivery or collection of a fluid to or from an organ or anatomical region in a human or animal subject, the method including the step of supporting a vessel associated with the organ or anatomical region. The devices and methods may be used to deliver, remove or recirculate a therapeutic agent to an organ or anatomical region.

    摘要翻译： 本发明提供了用于器官和解剖区域灌注中的装置和方法。 在一个方面，本方法提供了一种用于在人或动物对象中支撑血管的经皮递送装置，包括用于在输送流体或从其收集流体的过程中支撑血管的装置。 在另一方面，本发明提供了一种用于将流体递送或收集于人或动物受试者中的器官或解剖区域的方法，所述方法包括支撑与器官或解剖区域相关联的血管的步骤。 所述装置和方法可用于递送，移除或再循环治疗剂至器官或解剖区域。

    System and method to effect the mitral valve annulus of a heart
    35.
    发明授权
    System and method to effect the mitral valve annulus of a heart 有权
    影响心脏二尖瓣环的系统和方法

    公开(公告)号：US06964683B2

    公开(公告)日：2005-11-15

    申请号：US10798728

    申请日：2004-03-10

    申请人： Leonard Kowalsky ,  Gregory D. Nieminen ,  Ryan H. Braxtan ,  Mark L. Mathis

    发明人： Leonard Kowalsky ,  Gregory D. Nieminen ,  Ryan H. Braxtan ,  Mark L. Mathis

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2451

    摘要： An assembly for effecting the condition of a mitral valve annulus includes a mitral valve therapy device, a coupling structure carried by the device, a catheter, a second coupling structure, and a locking member. To implant the device, the device is first releasably locked to a pushing member by the coupling structures and the locking member. When the device is positioned within the coronary sinus adjacent the mitral valve annulus and deployed, the coupling structures may be released from each other by the release of the locking member.

    摘要翻译： 用于实现二尖瓣环的状态的组件包括二尖瓣治疗装置，由装置承载的联接结构，导管，第二联接结构和锁定构件。 为了植入装置，装置首先通过联接结构和锁定构件可释放地锁定到推动构件。 当装置定位在邻近二尖瓣环并展开的冠状窦内时，联接结构可以通过释放锁定构件而相互释放。

    Device, assembly and method for mitral valve repair
    36.
    发明授权
    Device, assembly and method for mitral valve repair 有权
    二尖瓣修复的装置，装配和方法

    公开(公告)号：US06797001B2

    公开(公告)日：2004-09-28

    申请号：US10095507

    申请日：2002-03-11

    申请人： Mark L. Mathis ,  Gregory D. Nieminen

    发明人： Mark L. Mathis ,  Gregory D. Nieminen

    IPC分类号： A61F206

    CPC分类号： A61F2/2451 ,  Y10S623/904

    摘要： A mitral valve therapy device effects the condition of a mitral valve annulus of a heart. The device includes an elongated member dimensioned to be placed in the coronary sinus of the heart adjacent the mitral valve annulus. The elongated member is flexible when placed in the heart in a first orientation to position the device in the coronary sinus adjacent the mitral valve annulus and relatively inflexible when rotated into a second orientation after the device is positioned in the coronary sinus adjacent to the mitral valve annulus to substantially straighten and increase the radius of curvature of the mitral valve annulus.

    摘要翻译： 二尖瓣治疗装置影响心脏二尖瓣环的状况。 该装置包括细长构件，其尺寸设置为放置在邻近二尖瓣环的心脏的冠状窦内。 细长构件在以第一取向放置在心脏中时是柔性的，以将装置定位在邻近二尖瓣环的冠状窦中，并且在将装置定位在与二尖瓣邻近的冠状窦内的第二取向时相对不灵活 环形件以基本上拉直并增加二尖瓣环的曲率半径。