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公开(公告)号：US20070142440A1
公开(公告)日：2007-06-21
申请号：US10590724
申请日：2005-01-13
申请人： Lars Burgdorf , Hans-Peter Buchstaller , Frank Stieber , Christiane Amendt , Hartmut Greiner , Matthias Grell , Christ8an Sirrenberg , Frank Zenke
发明人： Lars Burgdorf , Hans-Peter Buchstaller , Frank Stieber , Christiane Amendt , Hartmut Greiner , Matthias Grell , Christ8an Sirrenberg , Frank Zenke
IPC分类号： C07D211/84 , A61K31/4412
CPC分类号： C07D213/81 , C07D401/12
摘要： The invention relates to substituted arylamide derivatives of the formula I, the preparation and use thereof for the preparation of a medicament for the treatment of diseases, in particular tumours and/or diseases that are caused, mediated and/or propagated by angiogenesis. Compounds of the formula I are effective inhibitors of tyrosine kinases, in particular TIE-2 and VEGFR, and of Raf kinases.
摘要翻译： 本发明涉及式I的取代的芳基酰胺衍生物，其制备和用途，用于制备用于治疗由血管发生引起，介导和/或传播的疾病，特别是肿瘤和/或疾病的药物。 式I化合物是酪氨酸激酶，特别是TIE-2和VEGFR以及Raf激酶的有效抑制剂。
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公开(公告)号：US20080234299A1
公开(公告)日：2008-09-25
申请号：US11913149
申请日：2006-03-17
IPC分类号： A61K31/517 , C07D239/88 , A61P35/00
CPC分类号： C07D239/91 , C07D239/90
摘要： Compounds of the formula (I), in which R, R1, R2, R3, R4, R5, R6, R7, R8, Z1, Z2, Z3, k and Y1 have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours.
摘要翻译： 式（I）化合物，其中R 1，R 2，R 2，R 3，R 4， R 5，R 6，R 7，R 8，Z 1，...， Z 2，Z 3，Z和Y 1具有权利要求1中所示的含义，特别可以用于 治疗肿瘤。
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公开(公告)号：US08501754B2
公开(公告)日：2013-08-06
申请号：US12668864
申请日：2008-06-16
IPC分类号： A01N43/54 , A61K31/517 , C07D401/00
CPC分类号： C07D239/84 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D417/14
摘要： Novel quinazolinamide derivatives of the formula (I), in which R1-R3 have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新颖的喹唑啉酰胺衍生物，其中R1-R3具有权利要求1所示的含义，是HSP90抑制剂，可用于制备用于治疗其中抑制，调节和/或 HSP90的调节发挥作用。
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公开(公告)号：US07906657B2
公开(公告)日：2011-03-15
申请号：US12301067
申请日：2007-04-20
IPC分类号： C07D261/06 , C07D231/12 , C07D401/10 , C07D403/10 , A61K31/501 , A61K31/497 , A61K31/454 , A61K31/4427 , A61K31/415
CPC分类号： C07D231/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R1-R6 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新的1,5-二苯基吡唑衍生物，其中R 1 -R 6具有权利要求1所述的含义，是HSP90抑制剂，可用于制备用于治疗其中抑制，调节 和/或调节HSP90起作用。
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公开(公告)号：US08546565B2
公开(公告)日：2013-10-01
申请号：US13133495
申请日：2009-11-12
IPC分类号： C07D239/70 , A01N43/54
CPC分类号： C07D403/12 , C07D403/06 , C07D403/14
摘要： Novel quinazolinamide derivatives of the formula (I), in which R1-R5 and X have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新型喹唑啉酰胺衍生物，其中R1-R5和X具有权利要求1所述的含义，是HSP90抑制剂，可用于制备用于治疗其中抑制，调节和 /或HSP90调节起作用。
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公开(公告)号：US08119795B2
公开(公告)日：2012-02-21
申请号：US12301140
申请日：2007-04-20
IPC分类号： A61K31/4196 , C07D503/12 , C07D249/12 , C07D401/12
CPC分类号： C07D249/08 , C07D401/12 , C07D403/12
摘要： Novel triazole derivatives of the formula (I) in which R1-R6 and Y have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新型三唑衍生物，其中R 1 -R 6和Y具有权利要求1所述的含义，是HSP90抑制剂，可用于制备用于治疗其中抑制，调节和/ 或调制HSP90起作用。
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公开(公告)号：US20110028485A1
公开(公告)日：2011-02-03
申请号：US12883428
申请日：2010-09-16
IPC分类号： A61K31/415 , C07D231/12 , C07D403/12 , C07D401/12 , C07D405/12 , C07D413/12 , A61K31/496 , A61K31/4439 , A61K31/422 , A61K31/501 , A61K31/497 , A61P35/00 , A61P35/04 , A61P37/00 , A61P31/00 , A61P9/10 , A61P31/12 , A61P3/10 , A61P11/06 , A61P17/06 , A61P25/00 , A61P1/00
CPC分类号： C07D231/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R1-R6 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新的1,5-二苯基吡唑衍生物，其中R 1 -R 6具有权利要求1所述的含义，是HSP90抑制剂，可用于制备用于治疗其中抑制，调节 和/或调节HSP90起作用。
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公开(公告)号：US20090325974A1
公开(公告)日：2009-12-31
申请号：US12301067
申请日：2007-04-20
IPC分类号： A61K31/501 , C07D231/12 , A61K31/415 , A61K31/496 , C07D403/12 , A61P35/00
CPC分类号： C07D231/12 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R1-R6 have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新的1,5-二苯基吡唑衍生物，其中R 1 -R 6具有权利要求1所示的含义，是HSP90抑制剂，可用于制备用于治疗其抑制，调节 和/或调节HSP90起作用。
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公开(公告)号：US08791129B2
公开(公告)日：2014-07-29
申请号：US13819109
申请日：2011-08-31
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： A61K31/517 , A61K31/675 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07F9/65583
摘要： Novel quinazolinamide derivatives of the formula (I), in which R1-R43 and X have the meanings indicated in Claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新颖的喹唑啉酰胺衍生物，其中R1-R43和X具有权利要求1所述的含义，是HSP90抑制剂，可用于制备用于治疗其中抑制，调节和 /或HSP90调节起作用。
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公开(公告)号：US20130178443A1
公开(公告)日：2013-07-11
申请号：US13819109
申请日：2011-08-31
IPC分类号： A61K31/517 , C07D401/14 , A61K45/06 , C07D405/14 , C07F9/6558 , A61K31/675 , C07D403/06 , C07D403/14
CPC分类号： A61K31/517 , A61K31/675 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07F9/65583
摘要： Novel quinazolinamide derivatives of the formula (I), in which R1-R43 and X have the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.
摘要翻译： 式（I）的新型喹唑啉酰胺衍生物，其中R1-R43和X具有权利要求1所述的含义，是HSP90抑制剂，可用于制备用于治疗其中抑制，调节和 /或HSP90调节起作用。
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