-
公开(公告)号:US4810497A
公开(公告)日:1989-03-07
申请号:US147208
申请日:1988-01-22
Applicant: David F. Horrobin
Inventor: David F. Horrobin
IPC: A61K33/18 , A61K31/19 , A61K31/195 , A61K31/20 , A61K31/22 , A61K31/60 , A61K33/00 , A61K33/14 , A61P25/28 , A61K31/61 , A61K31/615 , A61K33/04
Abstract: Presenile and senile dementia, in particular Alzheimer's disease, can be combated or alleviated by administration of an effective amount of a physiologically acceptable lithium compound and an essential fatty acid or a physiologically acceptable salt thereof.
-
公开(公告)号:US4806569A
公开(公告)日:1989-02-21
申请号:US45545
申请日:1987-05-04
Applicant: David F. Horrobin
Inventor: David F. Horrobin
IPC: A61K31/19 , A23D9/00 , A23L1/30 , A23L1/325 , A23L1/48 , A61K31/16 , A61K31/20 , A61K31/22 , A61K31/23 , A61K31/557 , A61K35/56 , A61K35/60 , A61K36/00 , A61K36/185 , A61K38/00 , A61P3/08 , A61P11/00 , A61P13/02 , A61P15/00 , A61P25/30 , A61P27/16 , A61P35/00 , A61P37/08
CPC classification number: A61K35/60 , A23D9/00 , A61K31/20 , A61K31/23 , A61K31/557 , A61K36/185 , Y10S514/861 , Y10S514/866
Abstract: A method of treatment of atopic disorders, including eczema, asthma, allergies (especially allergic rhinitis), migraine and disorders associated with atopy including Crohn's disease, ulcerative colitis, otitis media, nephrotic syndrome, or benign breast disease, or breast or other cancer, or diabetes, or alcoholism, with effective amounts of one or more of the metabolites of linoleic acid (GLA, DGLA, AA, 22:4n-6 or 22:5n-6) and one or more of the metabolites of .alpha.-linolenic acid (18:4n-3), 20:4n-3, 20:5n-3, 22:5n-3 or 22:6n-3) are administered as such or in the form of an ester, salt, amide or other derivative convertible in the body thereto along or in an acceptable pharmaceutical carrier or diluent.
-
公开(公告)号:US4738853A
公开(公告)日:1988-04-19
申请号:US719953
申请日:1985-04-04
Applicant: David F. Horrobin
Inventor: David F. Horrobin
CPC classification number: A23K50/75 , A23K20/158 , Y10S426/807
Abstract: A method of maintaining hens or other domesticated birds for egg production, comprises giving the birds feed supplemented with .gamma.-linolenic acid or one or more higher acids in the n-6 series, in the form of the free acid or as an ester, amide, phospholipid, salt or other physiologically acceptable derivative convertible in the bird's body to, or having the effect of, the free acid.
Abstract translation: 维持母鸡或其他驯养的鸡用于产蛋的方法包括以游离酸形式或作为酯酰胺给予在n-6系列中补充有γ-亚麻酸或一种或多种高级酸的鸟饲料 ,磷脂,盐或其他生理学上可接受的衍生物在鸟体内转化为或具有游离酸的作用。
-
公开(公告)号:US4302447A
公开(公告)日:1981-11-24
申请号:US89293
申请日:1979-10-30
Applicant: David F. Horrobin
Inventor: David F. Horrobin
IPC: A61K31/43 , A61K31/545 , A61K33/30 , A61K31/20 , A61K31/54
CPC classification number: A61K31/545 , A61K31/43 , A61K33/30 , Y10S514/825 , Y10S514/899 , Y10S514/909
Abstract: Compositions and use of .gamma.-linolenic acids and related materials alone or with zinc and or .beta.-lactam antibiotics to treat schizophrenia, obesity, menstrual disorders, skin disorders and other conditions, and .beta.-lactam antibiotics alone to treat schizophrenia.
Abstract translation: 单独或与锌和/或β-内酰胺抗生素一起使用γ-亚麻酸和相关材料来治疗精神分裂症,肥胖症,月经失调,皮肤病和其他病症,以及单独使用β-内酰胺类抗生素治疗精神分裂症。
-
公开(公告)号:US4273763A
公开(公告)日:1981-06-16
申请号:US4924
申请日:1979-01-19
Applicant: David F. Horrobin
Inventor: David F. Horrobin
IPC: A61K31/43 , A61K31/545 , A61K33/30 , A61K31/20 , A61K31/315 , A61K31/54
CPC classification number: A61K31/545 , A61K31/43 , A61K33/30 , Y10S514/825 , Y10S514/899 , Y10S514/909
Abstract: Compositions and use of .gamma.-linolenic acids and related materials alone or with zinc and or .beta.-lactam antibiotics to treat schizophrenia, and .beta.-lactam antibiotics alone to treat schizophrenia.
Abstract translation: 单独或与锌和/或β-内酰胺抗生素一起使用γ-亚麻酸和相关材料来治疗精神分裂症,单独使用β-内酰胺类抗生素治疗精神分裂症。
-
公开(公告)号:US06441038B1
公开(公告)日:2002-08-27
申请号:US09686629
申请日:2000-10-12
Applicant: Cari Loder , David F. Horrobin
Inventor: Cari Loder , David F. Horrobin
IPC: A61K31195
CPC classification number: A61K31/55 , A61K45/06 , A61K2300/00
Abstract: A method of treatment of disorders of neurological origin and drug formulations for use in the method are disclosed. These conditions comprise fatigue and associated syndromes of pain, weakness and depressed mood which are associated with chronic fatigue syndrome, brain injury and stroke, stress, fibromyalgia, and irritable bowel syndrome. The treatment comprises administering to a patient in need thereof a selective inhibitor of noradrenaline reuptake combined with either phenylalanine or tyrosine in the same dosage form or the same pack.# The noradrenergic drug may be selected from lofepramine, desipramine or reboxetine. The selective inhibitor may be a combined inhibitor of both noradrenaline and serotonin reuptake such as venlafaxine, duloxetine or milnacipran, or an inhibitor of both noradrenaline and dopamine reuptake such as bupropion.
Abstract translation: 公开了一种治疗神经源性疾病的方法和用于该方法的药物制剂。 这些病症包括与慢性疲劳综合征,脑损伤和中风,压力,纤维肌痛和肠易激综合征相关的疲劳和相关的疼痛,虚弱和抑郁情绪综合征。 该治疗包括向有需要的患者施用去甲肾上腺素再摄取的选择性抑制剂与相同剂型或相同包装中的苯丙氨酸或酪氨酸组合。#去甲肾上腺素能药可以选自洛哌匹灵,地昔帕明或瑞波西汀。 选择性抑制剂可以是去甲肾上腺素和5-羟色胺再摄取的组合抑制剂,如文拉法辛,度洛西汀或米那普仑,或去甲肾上腺素和多巴胺再摄入如安非他酮的抑制剂。
-
公开(公告)号:US5888541A
公开(公告)日:1999-03-30
申请号:US784105
申请日:1997-01-15
Applicant: David F. Horrobin , Brenda E. Reynolds
Inventor: David F. Horrobin , Brenda E. Reynolds
IPC: A61K31/201 , A61K35/78 , A61K9/20
CPC classification number: A61K31/201
Abstract: Increase gut calcium absorption in humans or animals by the administration of GLA, DGLA or LA as such or in salt or other pharmacologically acceptable form, optionally in association with EPA, DHA or other EFA in similar forms, specifically useful in the treatment of osteoporosis.
Abstract translation: 通过施用GLA,DGLA或LA本身或以盐或其他药理学上可接受的形式,任选地与EPA,DHA或其他类似形式的EFA相关联地增加对人或动物的肠吸收钙吸收,特别可用于治疗骨质疏松症。
-
公开(公告)号:US5620701A
公开(公告)日:1997-04-15
申请号:US600005
申请日:1996-02-14
Applicant: David F. Horrobin , Yung-Sheng Huang
Inventor: David F. Horrobin , Yung-Sheng Huang
IPC: A61K31/23 , A23D9/00 , A23L1/30 , A61K8/00 , A61K8/30 , A61K8/37 , A61K8/96 , A61P13/02 , A61P15/00 , A61P17/00 , A61P25/04 , A61Q5/00 , A61Q19/00 , C07C69/587 , C11B3/10 , C11B7/00 , C11D3/06 , A61K9/70 , A61K9/14 , A61K31/20 , A61K47/12
CPC classification number: A23D9/00 , A61K31/23 , C07C69/587
Abstract: Atopic eczema, breast pain or premenstrual syndrome are treated by administering to a person in need of same a composition containing at least 20% di-linoleoyl-mono-gamma-linolenyl glycerol by weight.
-
公开(公告)号:US5583159A
公开(公告)日:1996-12-10
申请号:US408135
申请日:1995-03-21
Applicant: David F. Horrobin , Catherine A. Scott
Inventor: David F. Horrobin , Catherine A. Scott
IPC: A61K31/20 , A61K31/202 , A61P25/00 , A61P43/00
CPC classification number: A61K31/202 , A61K31/20
Abstract: Damage to internal tissues, and particularly to the central nervous system as a consequence of exposure to ionizing radiation is prevented or treated by administration of GLA and/or DGLA. Medicaments containing GLA and/or DGLA for such treatment or prevention may also further comprise EPA and/or DHA.
Abstract translation: 通过施用GLA和/或DGLA来防止或治疗由于暴露于电离辐射而对内部组织,特别是对中枢神经系统的损伤。 含有GLA和/或DGLA用于治疗或预防的药物还可以进一步包含EPA和/或DHA。
-
公开(公告)号:US5508307A
公开(公告)日:1996-04-16
申请号:US378708
申请日:1995-01-26
Applicant: David F. Horrobin , Catherine A. Scott
Inventor: David F. Horrobin , Catherine A. Scott
IPC: A61K31/20 , A61K20060101 , A61K9/08 , A61K31/201 , A61K31/202 , A61K31/203 , A61K33/00
CPC classification number: A61K31/20
Abstract: Method of safe intravenous administration of fatty acid(s), and in particular the n-6 and n-3 series essential fatty acids and conjugated fatty acids, whereby the fatty acid(s) or a proportion thereof are administered in the form of lithium salts, and whereby the plasma lithium levels are regularly monitored to avoid haemolysis, preferably keeping the lithium level no higher than 0.7 millimolar in the long term and preferably also no higher than 0.4-0.5 millimolar in the first 24-48 hours or, where only a proportion of the fatty acids are administered as lithium salts, a corresponding proportion of said levels.
Abstract translation: 脂肪酸的安全静脉内给药方法,特别是n-6和n-3系列必需脂肪酸和共轭脂肪酸,其中脂肪酸或其一部分以锂的形式施用 盐,并且由此定期监测血浆锂水平以避免溶血,优选在长期内保持锂水平不高于0.7毫摩尔,优选在第一24-48小时内不超过0.4-0.5毫摩尔,或者仅在 一部分脂肪酸以锂盐的形式施用,相应比例的水平。
-
-
-
-
-
-
-
-
-