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31.发明申请SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS 审中-公开作为HISTAMINE-3（H3）受体配体的取代的羟基丙烯酰胺衍生物公开(公告)号：US20140296212A1
公开(公告)日：2014-10-02
申请号：US14177046
申请日：2014-02-10
申请人： Edward R. Bacon , Thomas R. Bailey , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Allison L. Zulli , Brigitte Lesur , Babu G. Sundar , Christophe Yue
发明人： Edward R. Bacon , Thomas R. Bailey , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Allison L. Zulli , Brigitte Lesur , Babu G. Sundar , Christophe Yue
IPC分类号： C07D403/12 , C07C217/54 , C07D211/22 , C07D209/44 , C07D215/02 , C07D207/08 , C07D217/04
CPC分类号： C07D403/12 , C07C217/54 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/27 , C07D209/44 , C07D211/14 , C07D211/22 , C07D211/38 , C07D211/46 , C07D215/02 , C07D215/06 , C07D217/04 , C07D241/08 , C07D295/108 , C07D295/185 , C07D401/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D471/04 , C07D487/04
摘要： The present invention provides compounds of formula I: their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.
摘要翻译： 本发明提供式I化合物：它们用作H3拮抗剂/反向激动剂，其制备方法及其药物组合物。
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公开(公告)号：US20120295882A1
公开(公告)日：2012-11-22
申请号：US13529378
申请日：2012-06-21
申请人： Edward R. Bacon , Thomas R. Bailey , Derek D. Dunn , Greg A. Hostetler , Robert J. McHugh , George C. Morton , Gerard C. Rosse , Joseph M. Salvino , Babu G. Sundar , Rabindranath Tripathy
发明人： Edward R. Bacon , Thomas R. Bailey , Derek D. Dunn , Greg A. Hostetler , Robert J. McHugh , George C. Morton , Gerard C. Rosse , Joseph M. Salvino , Babu G. Sundar , Rabindranath Tripathy
IPC分类号： A61K31/4355 , C07D491/20 , A61K31/438 , A61K31/444 , A61K31/506 , C07D495/20 , A61K31/497 , A61K31/4709 , A61K31/5377 , C07D491/22 , C07D513/04 , A61K31/4725 , A61K31/496 , A61P25/22 , A61P25/08 , A61P25/24 , A61P25/18 , A61P25/28 , A61P25/16 , A61P25/20 , A61P25/30 , A61P3/04 , A61P25/00 , C07D491/048
CPC分类号： C07D491/153 , C07D491/048 , C07D491/20 , C07D513/04
摘要： This application relates to tricyclic compounds of Formula I: including all stereoisomers, mixtures of stereoisomers, and salts thereof. This application also relates to compositions comprising compounds of Formula I and uses therefore.
摘要翻译： 本申请涉及式I的三环化合物：包括所有立体异构体，立体异构体的混合物及其盐。 本申请还涉及包含式I化合物的组合物并因此使用。
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33.发明授权Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases 有权用于治疗和预防正痘病毒感染和相关疾病的化合物，组合物和方法公开(公告)号：US08124643B2
公开(公告)日：2012-02-28
申请号：US12643641
申请日：2009-12-21
申请人： Robert Jordan , Thomas R. Bailey , Susan R. Rippin
发明人： Robert Jordan , Thomas R. Bailey , Susan R. Rippin
IPC分类号： A61K31/403 , C07D209/56
CPC分类号： A61K31/403 , A61K31/407 , A61K31/4439
摘要： Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.
摘要翻译： 使用二，三和四环酰肼衍生物和类似物的方法以及含有它们的药物组合物用于治疗或预防病毒感染和与之相关的疾病，特别是由正痘病毒引起的那些病毒感染和相关疾病。
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34.发明申请COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF ORTHOPOXVIRUS INFECTIONS AND ASSOCIATED DISEASES 有权化合物，组合物和方法治疗和预防恶性疟原虫感染和相关疾病公开(公告)号：US20120020922A1
公开(公告)日：2012-01-26
申请号：US13194437
申请日：2011-07-29
IPC分类号： A61K31/4035 , A61K38/21 , A61K31/7056 , A61P31/12 , A61K39/00 , A61P29/00 , A61P31/00 , C07D209/94 , A61P31/14 , A61K39/395
CPC分类号： C07D209/70 , A61K31/4035 , A61K45/06 , C07D209/50 , C07D209/56 , C07D209/76 , C07D209/94 , C07D401/12 , C07D409/12 , C07D417/12
摘要： Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.
摘要翻译： 使用二，三和四环酰肼衍生物和类似物的方法以及含有它们的药物组合物用于治疗或预防病毒感染和与之相关的疾病，特别是由正痘病毒引起的那些病毒感染和相关疾病。
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35.发明申请ANTHRANILIC ACID DERIVATIVES USEFUL IN TREATING INFECTION WITH HEPATITIS C VIRUS 审中-公开用于治疗乙型肝炎病毒感染的抗坏血酸衍生物公开(公告)号：US20080269333A1
公开(公告)日：2008-10-30
申请号：US12168645
申请日：2008-07-07
IPC分类号： A61K31/196
CPC分类号： A61K31/195 , A61K31/24 , A61K31/41 , C07C235/24 , C07C237/04 , C07C255/54 , C07C323/60 , C07D257/04
摘要： The present invention provides pharmaceutical compositions useful in treating hepatitis C infection. The present invention also provides methods of treating hepatitis C infection by administering to a mammal the pharmaceutical compositions of the present invention.
摘要翻译： 本发明提供可用于治疗丙型肝炎感染的药物组合物。 本发明还提供了通过向哺乳动物施用本发明的药物组合物来治疗丙型肝炎感染的方法。
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36.发明授权Anthranilic acid derivatives useful in treating infection with hepatitis C virus 失效用于治疗丙型肝炎病毒感染的邻氨基苯甲酸衍生物公开(公告)号：US07408078B2
公开(公告)日：2008-08-05
申请号：US10682647
申请日：2003-10-08
IPC分类号： C07C229/34
CPC分类号： A61K31/195 , A61K31/24 , A61K31/41 , C07C235/24 , C07C237/04 , C07C255/54 , C07C323/60 , C07D257/04
摘要： The present invention provides pharmaceutical compositions useful in treating hepatitis C infection. The present invention also provides methods of treating hepatitis C infection by administering to a mammal the pharmaceutical compositions of the present invention.
摘要翻译： 本发明提供可用于治疗丙型肝炎感染的药物组合物。 本发明还提供了通过向哺乳动物施用本发明的药物组合物来治疗丙型肝炎感染的方法。
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37.发明授权1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents 失效1,2,4-氧杂唑并 - 苯氧基甲基咪唑和它们作为抗病毒剂的用途
公开(公告)号：US5175177A
公开(公告)日：1992-12-29
申请号：US731569
申请日：1991-07-17
申请人： Guy D. Diana , Thomas R. Bailey
发明人： Guy D. Diana , Thomas R. Bailey
IPC分类号： A61K31/42 , A61K31/4245 , A61P31/12 , C07D413/12
CPC分类号： C07D413/10
摘要： Compounds of the formula ##STR1## wherein: Y is alkylene of 3 to 9 carbon atoms;R.sub.1 is lower-alkyl, lower-alkoxy-(C.sub.1-3 -alkyl), lower-alkoxycarbonyl, cyclopropyl or trifluoromethyl;R.sub.2 and R.sub.3 independently are hydrogen, lower-alkyl, halogen, lower-alkoxy, nitro, trifluoromethyl or hydroxy; andR.sub.4 is hydrogen or lower-alkyl; where lower-alkyl and lower-alkoxy, each occurrence, have from 1-5 carbon atoms;with the proviso that when R.sub.1 is lower-alkyl, at least one of R.sub.2 and R.sub.3 is hydroxy; or pharmaceutically acceptable acid-addition salts thereof are useful as antiviral agents, particularly against picornaviruses, including numerous strains of rhinovirus.
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公开(公告)号：US08410149B2
公开(公告)日：2013-04-02
申请号：US12914400
申请日：2010-10-28
IPC分类号： A61K31/175 , A61K31/433 , C07C281/06 , C07D285/04
CPC分类号： C07C311/49 , A61K31/18 , A61K31/357 , A61K31/40 , A61K31/415 , A61K31/42 , A61K31/426 , A61K31/433 , A61K31/445 , A61K31/496 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K31/63 , C07D265/36 , C07D285/06 , Y02A50/387 , Y02A50/397
摘要： Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to Arenaviridae (Junin, Machupo, Guanavito, Sabia and Lassa), Filoviridae (ebola and Marburg viruses), Flaviviridae (yellow fever, omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
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公开(公告)号：US20110288075A1
公开(公告)日：2011-11-24
申请号：US13197243
申请日：2011-08-03
申请人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli
发明人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli
IPC分类号： A61K31/55 , A61K31/502 , A61K31/5025 , A61P25/00 , A61K31/50 , A61P25/28 , A61P25/18 , A61K31/501 , A61K31/5377
CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04
摘要： The present invention is directed to novel pyridazinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition/cognitive disorders.
摘要翻译： 本发明涉及介导酶活性的新的哒嗪酮衍生物。 特别地，这些化合物可有效治疗与组胺H3受体活性相关的疾病或疾病状态，包括例如神经变性疾病，睡眠/觉醒障碍，注意缺陷多动障碍和认知/认知障碍。
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公开(公告)号：US20100273779A1
公开(公告)日：2010-10-28
申请号：US12815813
申请日：2010-06-15
申请人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli
发明人： Edward R. Bacon , Thomas R. Bailey , Nadine C. Becknell , Sankar Chatterjee , Derek Dunn , Greg A. Hostetler , Robert L. Hudkins , Kurt A. Josef , Lars J.S. Knutsen , Ming Tao , Allison L. Zulli
IPC分类号： A61K31/55 , C07D403/12 , A61K31/501 , A61K31/502 , C07D495/04 , A61P3/04 , A61P9/10 , A61P11/00 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/28 , A61P1/00 , A61P29/00
CPC分类号： C07D498/04 , C07D237/14 , C07D237/26 , C07D237/32 , C07D237/36 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/04 , C07D495/04
摘要： The present invention is directed to novel pyridizinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition.
摘要翻译： 本发明涉及介导酶活性的新型吡哒嗪酮衍生物。 特别地，这些化合物可有效治疗与组胺H3受体活性相关的疾病或疾病状态，包括例如神经变性疾病，睡眠/觉醒障碍，注意力缺陷多动障碍和认知。
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