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68 条记录 (耗时 0.023 秒)

    Formulations for the administration of fluoxetine
    32.
    发明授权
    Formulations for the administration of fluoxetine 失效
    氟西汀治疗剂型

    公开(公告)号：US06512010B1

    公开(公告)日：2003-01-28

    申请号：US08892118

    申请日：1997-07-14

    申请人： Robert M. Gale ,  Melinda K. Nelson ,  Michel J. N. Cormier ,  Suneel K. Gupta ,  Patricia S. Campbell

    发明人： Robert M. Gale ,  Melinda K. Nelson ,  Michel J. N. Cormier ,  Suneel K. Gupta ,  Patricia S. Campbell

    IPC分类号： A61K3135

    CPC分类号： A61K9/7084 ,  A61K31/135 ,  A61K31/138 ,  A61K31/57 ,  A61K2300/00

    摘要： Composition of matter for application to a body surface or membrane to administer fluoxetine by permeation through the body surface or membrane, the composition comprising fluoxetine to be administered, at a therapeutically effective rate, alone or in combination with a permeation enhancer or mixture. A preferred embodiment is directed to the transdermal administration of fluoxetine at reduced skin irritation levels wherein fluoxetine, preferably provided as fluoxetine acetate, is coadministered with a corticosteroid such as hydrocortisone. Also disclosed are drug delivery devices containing the fluoxetine or fluoxetine and enhancer composition and methods for the transdermal administration of the fluoxetine and fluoxetine/enhancer composition.

    摘要翻译： 用于通过穿过身体表面或膜透过体外表面或膜施用氟西汀的物质的组成，所述组合物包含单独或与渗透促进剂或混合物组合的待施用氟西汀。 优选的实施方案涉及在减少的皮肤刺激水平下透皮给药氟西汀，其中氟西汀，优选以醋酸氟西汀提供，与皮质类固醇如氢化可的松共同施用。 还公开了含有氟西汀或氟西汀和增强剂组合物的药物递送装置和用于透皮给药氟西汀和氟西汀/增强剂组合物的方法。

    Pharmaceutical compositions for treating priapism and peyronie's syndrome
    33.
    发明授权
    Pharmaceutical compositions for treating priapism and peyronie's syndrome 失效
    用于治疗阴茎异常勃起和白血病综合征的药物组合物

    公开(公告)号：US6113939A

    公开(公告)日：2000-09-05

    申请号：US482366

    申请日：1995-06-07

    申请人： Virgil A. Place ,  Robert M. Gale ,  Randall G. Berggren

    发明人： Virgil A. Place ,  Robert M. Gale ,  Randall G. Berggren

    IPC分类号： A61F5/41 ,  A61K9/00 ,  A61M31/00 ,  A61F6/06

    CPC分类号： A61M31/00 ,  A61F5/41 ,  A61K9/0034 ,  A61M31/002 ,  A61M2210/167

    摘要： A composition for the treatment of impotence via delivery to the urethra comprises a vasoactive prostaglandin and a polyethylene glycol dispersant having sufficient viscosity to be retained without spillage from a urethra receivable insert. The composition can additionally contain an .alpha.-blocker. Suppositories can be formulated that are small enough for administration to the male urethra, and that dissolve, melt or bioerode within the urethra to release the active agent(s). The suppositories can contain vasodilators other than prostaglandins as the active for the treatment of impotence. Suppositories can also be formulated that contain active agents useful in the treatment of priapism or Peyronie's syndrome.

    摘要翻译： 用于通过递送至尿道治疗阳A的组合物包括血管活性前列腺素和具有足够粘度的聚乙二醇分散剂，其不会从尿道可接收的插入物中溢出而被保留。 该组合物可另外含有α-阻滞剂。 栓剂可以配制成足够小以用于给予男性尿道，并且在尿道内溶解，熔化或生物代谢以释放活性剂。 栓剂可以含有除前列腺素之外的血管扩张剂作为治疗阳the的活性物质。 也可以配制栓剂，其含有用于治疗阴茎异常勃起或佩罗尼氏综合征的活性剂。

    Segmented device for simultaneous delivery of multiple beneficial agents
    35.
    发明授权
    Segmented device for simultaneous delivery of multiple beneficial agents 失效
    用于同时传送多个有益试剂的分段装置

    公开(公告)号：US5443461A

    公开(公告)日：1995-08-22

    申请号：US114800

    申请日：1993-08-31

    申请人： Linda E. Atkinson ,  John T. Dunn ,  Robert M. Gale ,  David L. Rivera

    发明人： Linda E. Atkinson ,  John T. Dunn ,  Robert M. Gale ,  David L. Rivera

    IPC分类号： A61K9/22 ,  A61K9/48

    CPC分类号： A61K9/4808

    摘要： Diffusional delivery devices are constructed in two or more compartments, each containing a separate drug or other beneficial agent, and each arranged to permit diffusion of the agent out of the device through an individually-characterized agent-permeable wall segment. The diffusion rates of the various agents relative to one another are set and controlled by the parameters of the individual wall segments, such as the surface area of the wall segment, the average thickness of the wall segment, and the permeability of the wall segment for the particular agent. The permeability may be varied by variations in the chemical composition of the wall segment. Using these parameters rather than blending the agents at calculated ratios in a single formulation for diffusion through a single wall permits a wider range of, and greater flexibility in, variation between the diffusion rates of the different agents. This is of value when the simultaneous administration of agents at a specified ratio is desired.

    摘要翻译： 扩散递送装置构造在两个或更多个隔室中，每个隔室含有单独的药物或其它有益剂，并且每个隔室布置成允许药剂通过单独表征的药剂可渗透壁段从装置中扩散出设备。 各种试剂相对于彼此的扩散速率由单个壁段的参数设定和控制，例如壁段的表面积，壁段的平均厚度和壁段的渗透率 特定的代理。 渗透率可以通过壁段的化学组成的变化而变化。 使用这些参数而不是以单一制剂计算的比例混合试剂以通过单个壁扩散，允许不同试剂的扩散速率之间的变化范围更宽且更大的灵活性。 当需要以特定比例同时施用药剂时，这是有价值的。

    Method for treating nocturnal angina
    36.
    发明授权
    Method for treating nocturnal angina 失效
    治疗夜间心绞痛的方法

    公开(公告)号：US4954344A

    公开(公告)日：1990-09-04

    申请号：US269835

    申请日：1988-11-10

    申请人： Robert M. Gale

    发明人： Robert M. Gale

    IPC分类号： A61K9/70

    CPC分类号： A61K9/703 ,  A61K9/7069 ,  A61K9/7084 ,  Y10S514/929

    摘要： A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.

    摘要翻译： 公开了一种医用绷带，其包括含有凝胶流体，流变剂和药物的贮存器。 还公开了使用绷带产生有益效果的方法。

    Medical bandage for administering vasodilator drug
    38.
    发明授权
    Medical bandage for administering vasodilator drug 失效
    用于管理血管扩张剂药物的医用绷带

    公开(公告)号：US4661105A

    公开(公告)日：1987-04-28

    申请号：US872369

    申请日：1986-06-09

    申请人： Robert M. Gale

    发明人： Robert M. Gale

    IPC分类号： A61K9/70 ,  A61K9/00

    CPC分类号： A61K9/703 ,  A61K9/7069 ,  A61K9/7084

    摘要： A medical bandage is disclosed comprising a reservoir containing a gelled fluid, rheological agent and a drug. A method of using the bandage for producing a beneficial effect is disclosed also.

    摘要翻译： 公开了一种医用绷带，其包括含有凝胶流体，流变剂和药物的贮存器。 还公开了使用绷带产生有益效果的方法。