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公开(公告)号：US08853178B2
公开(公告)日：2014-10-07
申请号：US13177462
申请日：2011-07-06
申请人： Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madelline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
发明人： Sanjay Bhanot , Lex M. Cowsert , Jacqueline R. Wyatt , Brett P. Monia , Madelline M. Butler , Robert McKay , Susan M. Freier , Kenneth W. Dobie
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
摘要翻译： 提供化合物，组合物和方法用于调节PTP1B的表达。 组合物包含靶向编码PTP1B的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。
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公开(公告)号：US06743909B2
公开(公告)日：2004-06-01
申请号：US10172911
申请日：2002-06-17
申请人： Lex M. Cowsert , Kenneth W. Dobie
发明人： Lex M. Cowsert , Kenneth W. Dobie
IPC分类号： C12N1585
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of PTPN12. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTPN12. Methods of using these compounds for modulation of PTPN12 expression and for treatment of diseases associated with expression of PTPN12 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节PTPN12的表达。 组合物包含靶向编码PTPN12的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTPN12表达和治疗与PTPN12表达相关的疾病的方法。
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公开(公告)号：US06613567B1
公开(公告)日：2003-09-02
申请号：US09663834
申请日：2000-09-15
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C07H2102
CPC分类号： C12N15/1138 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Her-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Her-2. Methods of using these compounds for modulation of Her-2 expression and for treatment of diseases associated with expression of Her-2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节Her-2的表达。 组合物包含靶向编码Her-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节Her-2表达和治疗与Her-2表达相关的疾病的方法。
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公开(公告)号：US06482644B1
公开(公告)日：2002-11-19
申请号：US09920668
申请日：2001-08-01
申请人： Lex M. Cowsert
发明人： Lex M. Cowsert
IPC分类号： C12Q168
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Dual specific phosphatase 8. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Dual specific phosphatase 8. Methods of using these compounds for modulation of Dual specific phosphatase 8 expression and for treatment of diseases associated with expression of Dual specific phosphatase 8 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节双重特异性磷酸酶8的表达。组合物包含靶向编码双重特异性磷酸酶8的核酸的反义化合物，特别是反义寡核苷酸8.使用这些化合物调节双特异性磷酸酶8的方法 提供了表达和用于治疗与双特异性磷酸酶8的表达相关的疾病。
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公开(公告)号：US06426220B1
公开(公告)日：2002-07-30
申请号：US09702327
申请日：2000-10-30
申请人： C. Frank Bennett , Lex M. Cowsert
发明人： C. Frank Bennett , Lex M. Cowsert
IPC分类号： C12Q168
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of calreticulin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding calreticulin. Methods of using these compounds for modulation of calreticulin expression and for treatment of diseases associated with expression of calreticulin are provided.
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公开(公告)号：US06335194B1
公开(公告)日：2002-01-01
申请号：US09496694
申请日：2000-02-02
IPC分类号： C07H2104
CPC分类号： C12N15/113 , A61K38/00 , C07B2200/11 , C07H21/00 , C12N15/1135 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12N2310/3521
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compounds for modulation of Survivin expression and for treatment of diseases associated with expression of Survivin are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节存活蛋白的表达。 组合物包含靶向编码存活蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节存活蛋白表达和治疗与存活蛋白表达相关的疾病的方法。
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公开(公告)号：US06306606B1
公开(公告)日：2001-10-23
申请号：US09721822
申请日：2000-11-22
IPC分类号： C12Q168
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of MP-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MP-1. Methods of using these compounds for modulation of MP-1 expression and for treatment of diseases associated with expression of MP-1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节MP-1的表达。 组合物包含靶向编码MP-1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节MP-1表达和治疗与MP-1表达有关的疾病的方法。
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公开(公告)号：US06300132B1
公开(公告)日：2001-10-09
申请号：US09467642
申请日：1999-12-17
申请人： Brett P. Monia , Lex M. Cowsert
发明人： Brett P. Monia , Lex M. Cowsert
IPC分类号： A61K317115
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Telomeric repeat binding factor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Telomeric repeat binding factor 2. Methods of using these compounds for modulation of Telomeric repeat binding factor 2 expression and for treatment of diseases associated with expression of Telomeric repeat binding factor 2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节端粒重复结合因子2的表达。该组合物包含靶向编码端粒重复结合因子2的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节端粒重复的方法 提供了结合因子2表达和用于治疗与端粒重复结合因子2的表达相关的疾病。
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公开(公告)号：US06261840B1
公开(公告)日：2001-07-17
申请号：US09487368
申请日：2000-01-18
申请人： Lex M. Cowsert , Jacqueline Wyatt
发明人： Lex M. Cowsert , Jacqueline Wyatt
IPC分类号： C12N500
CPC分类号： C12N15/1137 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节PTP1B的表达。 组合物包含靶向编码PTP1B的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节PTP1B表达和治疗与PTP1B表达相关的疾病的方法。
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公开(公告)号：US06258790B1
公开(公告)日：2001-07-10
申请号：US09377309
申请日：1999-08-19
IPC分类号： C12N500
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/334 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compositions and methods are provided for modulating the expression of integrin &agr;4. Antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding integrin &agr;4 are preferred. Methods of using these compounds for modulating integrin &agr;4 expression and for treatment of diseases associated with expression of integrin &agr;4 are also provided.
摘要翻译： 提供组合物和方法用于调节整联蛋白α4的表达。 优选靶向编码整联蛋白α4的核酸的反义化合物，特别是反义寡核苷酸。 还提供了使用这些化合物调节整联蛋白α4表达和治疗与整联蛋白α4的表达相关的疾病的方法。
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