公开(公告)号：US09402962B2

公开(公告)日：2016-08-02

申请号：US13497375

申请日：2010-09-29

申请人： Catherine Anne Macdonald ,  Robert Veasey ,  Garen Kouyoumjian ,  Christopher Jones ,  Andrew Mark Lindsay

发明人： Catherine Anne Macdonald ,  Robert Veasey ,  Garen Kouyoumjian ,  Christopher Jones ,  Andrew Mark Lindsay

IPC分类号： A61M5/00 ,  A61M5/315 ,  A61M5/31 ,  A61M5/24

CPC分类号： A61M5/31593 ,  A61M5/24 ,  A61M5/3146 ,  A61M5/31501 ,  A61M5/31511 ,  A61M5/31555 ,  A61M2005/2407 ,  A61M2205/581

摘要： The present invention relates to an assembly for a drug delivery device comprising a proximal end, a distal end and a moveable member, a dose member, a fixed member and coupling means, wherein in a first state, the moveable member is moveable in an axial direction with respect to the fixed member and the dose member and the coupling means retains the dose member to the fixed member, and wherein in a second state of the assembly, the moveable member is permanently connected with the dose member by means of the coupling means and the dose member is released from the fixed member and the assembly is configured to set and dispense a dose of a fluid medicinal product out of an assembled cartridge by movement of the dose member. Furthermore it relates to a method for setting-up a drug delivery device.

摘要翻译： 本发明涉及一种用于药物输送装置的组件，其包括近端，远端和可移动构件，剂量构件，固定构件和联接装置，其中在第一状态下，可移动构件可在轴向 相对于固定构件和剂量构件的方向，并且联接装置将剂量构件保持到固定构件，并且其中在组件的第二状态下，可移动构件通过联接装置永久地与剂量构件连接 并且剂量构件从固定构件释放，并且组件构造成通过剂量构件的移动来将流体药物的剂量设置和分配出组装的筒。 此外，它涉及一种用于设置药物递送装置的方法。

公开(公告)号：US09402960B2

公开(公告)日：2016-08-02

申请号：US13395898

申请日：2010-09-29

申请人： Robert Veasey ,  Simon Lewis Bilton ,  Christopher Jones ,  Garen Kouyoumjian ,  Catherine Anne Macdonald

发明人： Robert Veasey ,  Simon Lewis Bilton ,  Christopher Jones ,  Garen Kouyoumjian ,  Catherine Anne Macdonald

IPC分类号： A61M5/315 ,  A61M5/24

CPC分类号： A61M5/31535 ,  A61M5/24 ,  A61M5/31543 ,  A61M5/31555 ,  A61M5/3156 ,  A61M5/3158 ,  A61M5/31593 ,  A61M2005/2407

摘要： A plunger and a lever are arranged in a body and provided with engaging elements engaging the lever with the plunger. The lever is disengageable from the plunger by a shift of the lever, thus enabling a movement of the plunger relatively to the body in the proximal direction.

摘要翻译： 柱塞和杠杆布置在主体中并且设置有与杠杆与柱塞接合的接合元件。 杠杆通过杠杆的移动而与柱塞脱离，从而使得柱塞能够在近端方向上相对于身体移动。

公开(公告)号：US09358340B2

公开(公告)日：2016-06-07

申请号：US13496337

申请日：2010-09-29

申请人： Christopher Jones ,  Robert Veasey ,  Garen Kouyoumjian ,  Catherine Anne MacDonald ,  Michael Jugl ,  Gunther Sendatzki

发明人： Christopher Jones ,  Robert Veasey ,  Garen Kouyoumjian ,  Catherine Anne MacDonald ,  Michael Jugl ,  Gunther Sendatzki

IPC分类号： A61M5/24 ,  A61M5/31 ,  A61M5/315 ,  A61M5/32 ,  A61M5/34

CPC分类号： A61M5/24 ,  A61M5/3146 ,  A61M5/31555 ,  A61M5/3202 ,  A61M5/3293 ,  A61M5/344 ,  A61M5/347 ,  A61M2005/2407 ,  A61M2005/2477 ,  A61M2005/2488 ,  A61M2205/6045 ,  A61M2207/00 ,  Y10T29/49826

摘要： A method for securing a cartridge (4) in a cartridge holder (3) is provided, the method comprising the steps of inserting the cartridge (4) into the cartridge holder (3), the cartridge holder (3) having a proximal end and a distal end, axially displacing the cartridge (4) in a proximal direction with respect to the cartridge holder (3) from a distal initial position to a proximal end position and securing the cartridge (4) in the end position against displacement in the distal direction with respect to the cartridge holder (3). An assembly for a drug delivery device (1) is provided comprising a cartridge (4), an adjusting member (12, 25, 28, 34) and a cartridge holder (3). The cartridge holder (3) has a distal end and a proximal end. The adjusting member (12, 25, 28, 34) is secured to the cartridge holder (3). The adjusting member (12, 25, 28, 34) holds a distal portion of the cartridge (4) at a distance with respect to a distal portion of the cartridge holder (3).

摘要翻译： 提供了一种用于将盒（4）固定在盒保持器（3）中的方法，所述方法包括以下步骤：将盒（4）插入盒保持器（3），盒保持器（3）具有近端和 一个远端，使药筒（4）相对于药筒保持器（3）的近端方向从远端初始位置轴向移位到近端位置，并将药筒（4）固定在终端位置，防止远端 方向相对于盒保持器（3）。 提供了一种用于药物输送装置（1）的组件，其包括盒（4），调节构件（12,25,28,34）和盒保持器（3）。 药筒保持器（3）具有远端和近端。 调节构件（12,25,28,34）固定在盒保持架（3）上。 调节构件（12,25,28,34）将盒（4）的远端部分相对于盒保持器（3）的远端部分保持一段距离。

公开(公告)号：US20120283651A1

公开(公告)日：2012-11-08

申请号：US13395599

申请日：2010-09-29

申请人： Robert Veasey ,  Simon Lewis Bilton ,  Christopher Jones ,  Garen Kouyoumjian ,  Catherine Anne MacDonald

发明人： Robert Veasey ,  Simon Lewis Bilton ,  Christopher Jones ,  Garen Kouyoumjian ,  Catherine Anne MacDonald

IPC分类号： A61M5/315

CPC分类号： A61M5/31543 ,  A61M5/31535 ,  A61M5/31555 ,  A61M5/3156 ,  A61M5/3158 ,  A61M5/31593 ,  A61M2005/2407

摘要： A plunger (4) having engaging means and a lever (5) are arranged in a body (1). The lever has a first pivot that is stationary with respect to the body in the direction of an axis, a second pivot, and a third pivot formed by an engaging element of the lever. The pivots are arranged in such a manner that a rotation of the lever with respect to the first pivot moves the second pivot and the third pivot in the same direction with respect to the axis. The engaging element and the engaging means are shaped such that the lever is disengaged from the plunger when the second pivot is moved relatively to the plunger in the proximal direction (30), and the plunger is engaged with the lever when the second pivot is moved in the distal direction (20).

摘要翻译： 具有接合装置和杆（5）的柱塞（4）布置在主体（1）中。 所述杠杆具有第一枢轴，所述第一枢轴在轴线方向相对于所述主体固定，第二枢轴和由所述杠杆的接合元件形成的第三枢轴。 所述枢轴以这样的方式设置，即所述杆相对于所述第一枢轴的旋转使所述第二枢轴和所述第三枢轴沿相对于所述轴线的相同方向移动。 接合元件和接合装置的形状使得当第二枢轴在近端方向（30）相对于柱塞移动时，杠杆与柱塞脱离，并且当第二枢轴移动时，柱塞与杠杆接合 在远端方向（20）。

公开(公告)号：US20120283646A1

公开(公告)日：2012-11-08

申请号：US13498372

申请日：2010-09-29

申请人： Garen Kouyoumjian ,  Robert Veasey ,  Christopher Jones ,  Catherine Anne Macdonald ,  Stephen Gilmore ,  George Cave

发明人： Garen Kouyoumjian ,  Robert Veasey ,  Christopher Jones ,  Catherine Anne Macdonald ,  Stephen Gilmore ,  George Cave

IPC分类号： A61M5/315 ,  A61M5/32

CPC分类号： A61M5/34 ,  A61M5/002 ,  A61M5/1456 ,  A61M5/2466 ,  A61M5/3146 ,  A61M5/31525 ,  A61M5/31533 ,  A61M5/31571 ,  A61M5/3202 ,  A61M5/3293 ,  A61M5/345

摘要： A drug delivery system comprises a drug delivery device which comprises a housing and a cartridge. The drug delivery device has a proximal end and a distal end. The drug delivery system further comprises a needle assembly which is attachable to the drug delivery device. The needle assembly and the drug delivery device are configured such that the cartridge is moved in the proximal direction with respect to the housing when the needle assembly is attached to the drug delivery device.

摘要翻译： 药物递送系统包括药物递送装置，其包括壳体和药筒。 药物递送装置具有近端和远端。 药物递送系统还包括可组装到药物递送装置上的针组件。 针组件和药物递送装置构造成使得当针组件附接到药物递送装置时，药筒相对于壳体在近侧方向上移动。

公开(公告)号：US09375535B2

公开(公告)日：2016-06-28

申请号：US13497378

申请日：2010-09-29

申请人： Robert Veasey ,  Simon Lewis Bilton ,  Christopher Jones ,  Garen Kouyoumjian ,  Catherine Anne Macdonald

发明人： Robert Veasey ,  Simon Lewis Bilton ,  Christopher Jones ,  Garen Kouyoumjian ,  Catherine Anne Macdonald

IPC分类号： A61M5/00 ,  A61M5/315 ,  A61M5/24 ,  A61M5/31

CPC分类号： A61M5/3158 ,  A61M5/24 ,  A61M5/31541 ,  A61M5/31543 ,  A61M5/31555 ,  A61M5/31556 ,  A61M2005/2407 ,  A61M2005/2477 ,  A61M2005/3126

摘要： According to one aspect, a resettable drive assembly for a drug delivery device is provided for. The resettable drive assembly may comprise a housing having a proximal end and a distal end, a piston rod being rotatable with respect to the housing and being axially displaceable with respect to the housing between a proximal start position and a distal end position, a drive member for distally displacing the piston rod towards the end position when dispensing a dose, and a stop member. The drive assembly may be configured such that the drive member is operable to interact with the piston rod for forming an unlockable first interlock, the first interlock being operable to block proximal movement of the piston rod with respect to the drive member. The drive assembly may be configured such that the stop member is operable to interact with the piston rod for forming an unlockable second interlock, the second interlock being operable to block proximal movement of the piston rod with respect to the housing. The drive assembly may be configured such that, when the drive assembly is in a drive mode, the first and second interlocks are locked such that proximal movement of the piston rod from the end position to the start position is prevented by the first interlock and the second interlock. The drive assembly may be configured such that, for switching the drive assembly from the drive mode to a reset mode, the piston rod is rotatable with respect to the drive member for unlocking the first interlock and the stop member and the piston rod are rotatable with respect to each other for unlocking the second interlock. The drive assembly may be configured such that, when the drive assembly is in the reset mode, the first interlock and the second interlock are unlocked such that proximal movement of the piston rod to the start position is allowed. Further, a drug delivery device and a use of a spring are provided for.

摘要翻译： 根据一个方面，提供了一种用于药物递送装置的可重置驱动组件。 可重置驱动组件可以包括具有近端和远端的壳体，活塞杆可相对于壳体旋转并且能够在近端起始位置和远端位置之间相对于壳体轴向移动，驱动构件 用于在分配剂量时将活塞杆朝向终端位置移动，以及止挡构件。 驱动组件可以构造成使得驱动构件可操作以与活塞杆相互作用以形成可解锁的第一互锁，第一互锁可操作以阻止活塞杆相对于驱动构件的近端运动。 驱动组件可以被配置为使得止动构件可操作以与活塞杆相互作用以形成可解锁的第二互锁，所述第二互锁可操作以阻止活塞杆相对于壳体的近端运动。 驱动组件可以构造成使得当驱动组件处于驱动模式时，第一和第二互锁被锁定，使得活塞杆从终端位置到起始位置的近端运动通过第一互锁来防止，并且 第二个互锁。 驱动组件可以被配置成使得为了将驱动组件从驱动模式切换到复位模式，活塞杆可相对于驱动构件旋转，用于解锁第一联锁装置，止动构件和活塞杆可随着 彼此相对以解锁第二互锁。 驱动组件可以被构造成使得当驱动组件处于复位模式时，第一互锁和第二联锁被解锁，使得允许活塞杆的近端运动到起始位置。 此外，提供了药物递送装置和弹簧的使用。

公开(公告)号：US09265891B2

公开(公告)日：2016-02-23

申请号：US13395840

申请日：2010-09-29

申请人： Catherine Anne MacDonald ,  Robert Veasey ,  Garen Kouyoumjian ,  Christopher Jones ,  Andrew Mark Lindsay ,  Michael Bainton

发明人： Catherine Anne MacDonald ,  Robert Veasey ,  Garen Kouyoumjian ,  Christopher Jones ,  Andrew Mark Lindsay ,  Michael Bainton

IPC分类号： A61M5/00 ,  A61M5/315 ,  A61M5/20

CPC分类号： A61M5/3155 ,  A61M2005/2073

摘要： An assembly of a drug delivery device with a longitudinal axis (L) is given, comprising a body (1) with a proximal end (2) and a distal end (3). The drug delivery device further comprises a drive assembly and a first button member (4). The drive assembly is at least partially arranged within the body (1) and is adapted to facilitate dispense of a medicinal product. The first button member (4) acts on the drive assembly to prepare the drug delivery device for dispensing the medicinal product. The first button member (4) is adapted to be detachable from the body (1) after the preparation of the drug delivery device is completed.

摘要翻译： 给出了具有纵向轴线（L）的药物递送装置的组件，包括具有近端（2）和远端（3）的主体（1）。 药物输送装置还包括驱动组件和第一按钮构件（4）。 驱动组件至少部分地布置在主体（1）内，并且适于便于分配药物。 第一按钮构件（4）作用在驱动组件上以制备用于分配药物的药物输送装置。 第一按钮构件（4）适于在药物输送装置的制备完成之后与主体（1）分离。

公开(公告)号：US08968259B2

公开(公告)日：2015-03-03

申请号：US13498906

申请日：2010-09-29

申请人： Robert Veasey ,  George Cave ,  Christopher Jones ,  Garen Kouyoumjian ,  Catherine Anne Macdonald

发明人： Robert Veasey ,  George Cave ,  Christopher Jones ,  Garen Kouyoumjian ,  Catherine Anne Macdonald

IPC分类号： A61M5/315 ,  F16H19/04 ,  A61M5/24

CPC分类号： A61M5/3158 ,  A61M5/24 ,  A61M5/31535 ,  A61M5/31543 ,  A61M5/31555 ,  A61M5/31558 ,  A61M5/31575 ,  A61M2005/2407 ,  A61M2005/2488 ,  A61M2005/3152 ,  Y10T74/18128

摘要： The present disclosure relates to a resettable drive mechanism for use in a drug delivery device. The drug delivery device is having a distal direction and a proximal direction. The drive mechanism comprises a drive rack engaged with a drive gear, a piston rack engaged with a piston gear and coupling means for coupling the drive gear with the piston gear. In a first state of the drive mechanism, the drive gear and the piston gear are coupled and the piston rack moves in distal direction when the drive rack is moved in distal direction. In a second state of the drive mechanism, the drive gear and the piston gear are decoupled and the piston rack is moveable in proximal direction for resetting the drive mechanism.

摘要翻译： 本公开涉及一种用于药物输送装置的可重置驱动机构。 药物输送装置具有远端方向和近端方向。 驱动机构包括与驱动齿轮接合的驱动齿条，与活塞齿轮接合的活塞齿轮和用于将驱动齿轮与活塞齿轮联接的联接装置。 在驱动机构的第一状态下，驱动齿轮和活塞齿轮联接，并且当驱动齿条沿远端方向移动时，活塞齿条沿远端方向移动。 在驱动机构的第二状态下，驱动齿轮和活塞齿轮脱离，并且活塞齿条能够在近端方向上移动以重新设置驱动机构。

公开(公告)号：US20120279329A1

公开(公告)日：2012-11-08

申请号：US13498906

申请日：2010-09-29

申请人： Robert Veasey ,  George Cave ,  Christopher Jones ,  Garen Kouyoumjian ,  Catherine Anne Macdonald

发明人： Robert Veasey ,  George Cave ,  Christopher Jones ,  Garen Kouyoumjian ,  Catherine Anne Macdonald

IPC分类号： F16H19/04

CPC分类号： A61M5/3158 ,  A61M5/24 ,  A61M5/31535 ,  A61M5/31543 ,  A61M5/31555 ,  A61M5/31558 ,  A61M5/31575 ,  A61M2005/2407 ,  A61M2005/2488 ,  A61M2005/3152 ,  Y10T74/18128

摘要： The present disclosure relates to a resettable drive mechanism for use in a drug delivery device. The drug delivery device is having a distal direction and a proximal direction. The drive mechanism comprises a drive rack engaged with a drive gear, a piston rack engaged with a piston gear and coupling means for coupling the drive gear with the piston gear. In a first state of the drive mechanism, the drive gear and the piston gear are coupled and the piston rack moves in distal direction when the drive rack is moved in distal direction. In a second state of the drive mechanism, the drive gear and the piston gear are decoupled and the piston rack is moveable in proximal direction for resetting the drive mechanism.

摘要翻译： 本公开涉及一种用于药物输送装置的可重置驱动机构。 药物输送装置具有远端方向和近端方向。 驱动机构包括与驱动齿轮接合的驱动齿条，与活塞齿轮接合的活塞齿轮和用于将驱动齿轮与活塞齿轮联接的联接装置。 在驱动机构的第一状态下，驱动齿轮和活塞齿轮联接，并且当驱动齿条沿远端方向移动时，活塞齿条沿远端方向移动。 在驱动机构的第二状态下，驱动齿轮和活塞齿轮脱离，并且活塞齿条能够在近端方向上移动以重新设置驱动机构。

公开(公告)号：US09463278B2

公开(公告)日：2016-10-11

申请号：US13395701

申请日：2010-09-29

申请人： Catherine Anne MacDonald ,  Robert Veasey ,  Christopher Jones ,  Garen Kouyoumjian

发明人： Catherine Anne MacDonald ,  Robert Veasey ,  Christopher Jones ,  Garen Kouyoumjian

IPC分类号： A61M5/24 ,  A61M5/31 ,  A61M5/315

CPC分类号： A61M5/24 ,  A61M5/3146 ,  A61M5/31543 ,  A61M5/31555 ,  A61M5/31556 ,  A61M5/3156 ,  A61M5/3158 ,  A61M2005/2407 ,  A61M2005/2488 ,  A61M2005/2492

摘要： A resettable drive mechanism for a drug delivery device (1) comprises a piston rod assembly (32) and an interaction member (23). The piston rod assembly (32) comprises a guide track (18) running along the piston rod assembly (32), the guide track (18) comprising at least one delivery section (18A) and at least one reset section (18B). The reset section (18B) is arranged to continue the delivery section (18A). The delivery section (18A) comprises at least one blocking means (19). The interaction member (23) is configured to cooperate with the guide track (18). For delivering a dose of a drug (24), the piston rod assembly (32) is axially displaceable in a dose delivery direction away from an axial starting position, the interaction member (23) cooperating with the delivery section (18A) and the blocking means (19) passing the interaction member (23) when the piston rod assembly (32) is displaced in the dose delivery direction. Axial displacement of the piston rod assembly (32) towards the axial starting position is prevented by mechanical interaction of the blocking means (19) and the interaction member (23) when the interaction member (23) cooperates with the delivery section (18A). For resetting the drug delivery device (1), the interaction member (23) is configured to cooperate with the reset section (18B), the piston rod assembly (32) being axially displaced towards the axial starting position, the blocking means (19) being offset from the interaction member (23) and passing the axial position of the interaction member (23) when the piston rod assembly (32) is axially displaced towards the axial starting position. Also, a piston rod assembly (32) is proposed.

摘要翻译： 用于药物输送装置（1）的可重置驱动机构包括活塞杆组件（32）和相互作用构件（23）。 活塞杆组件（32）包括沿着活塞杆组件（32）延伸的导轨（18），导轨（18）包括至少一个输送部分（18A）和至少一个复位部分（18B）。 复位部分（18B）布置成继续传送部分（18A）。 输送部分（18A）包括至少一个阻挡装置（19）。 相互作用构件（23）构造成与导轨（18）配合。 为了递送药物（24）的剂量，活塞杆组件（32）可以在远离轴向起始位置的剂量递送方向上轴向移位，相互作用构件（23）与输送段（18A）配合并阻塞 当活塞杆组件（32）在剂量递送方向上移位时，装置（19）使相互作用构件（23）通过。 当相互作用构件（23）与输送段（18A）配合时，通过阻挡装置（19）和相互作用构件（23）的机械相互作用来防止活塞杆组件（32）朝向轴向起始位置的轴向位移。 为了复位药物输送装置（1），相互作用构件（23）构造成与复位部分（18B）配合，活塞杆组件（32）朝着轴向起始位置轴向移位，阻挡装置（19） 当所述活塞杆组件（32）朝向所述轴向起始位置轴向移位时，所述相互作用构件（23）偏离所述相互作用构件（23）的轴向位置。 此外，提出了一种活塞杆组件（32）。