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公开(公告)号:US20120289981A1
公开(公告)日:2012-11-15
申请号:US13561911
申请日:2012-07-30
IPC分类号: A61B17/03
CPC分类号: A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
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公开(公告)号:US09066884B2
公开(公告)日:2015-06-30
申请号:US13561949
申请日:2012-07-30
IPC分类号: A61F2/00 , A61F2/08 , A61K9/70 , A61K38/17 , A61L27/22 , A61L27/36 , A61L27/38 , A61L27/48 , C12N5/077 , C07K14/435 , A61K35/12
CPC分类号: A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
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公开(公告)号:US20120296443A1
公开(公告)日:2012-11-22
申请号:US13561949
申请日:2012-07-30
IPC分类号: A61F2/02
CPC分类号: A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
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公开(公告)号:US20110167602A1
公开(公告)日:2011-07-14
申请号:US13071396
申请日:2011-03-24
CPC分类号: A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
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公开(公告)号:US20120296352A1
公开(公告)日:2012-11-22
申请号:US13561847
申请日:2012-07-30
IPC分类号: A61B17/03
CPC分类号: A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
摘要翻译: 丝被纯化以消除免疫原性成分(特别是丝胶蛋白),并且用于形成用于形成用于植入的组织支撑假体装置的织物。 织物可以携带官能团,药物和其他生物试剂。 应用包括疝修补,组织壁重建和器官支撑,如膀胱吊带。 丝纤维平行布置,并且任选地缠结(例如扭曲)以形成构造体; 可以在织物形成期间的任何点提取丝胶蛋白,留下具有优异拉伸强度和其它机械性能的丝素蛋白纤维构建体。
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公开(公告)号:US20120294906A1
公开(公告)日:2012-11-22
申请号:US13561885
申请日:2012-07-30
CPC分类号: A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
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公开(公告)号:US20120210547A1
公开(公告)日:2012-08-23
申请号:US13456860
申请日:2012-04-26
CPC分类号: A61K9/70 , A61F2/00 , A61F2/08 , A61K35/12 , A61K35/28 , A61K38/17 , A61L27/227 , A61L27/3608 , A61L27/3662 , A61L27/3804 , A61L27/3821 , A61L27/3834 , A61L27/386 , A61L27/3895 , A61L27/48 , A61L2430/10 , C07K14/43518 , C12N5/066 , C12N5/0663 , C12N2533/50 , Y10T428/249921 , Y10T428/298 , Y10T442/2566 , C08L89/00
摘要: Silk is purified to eliminate immunogenic components (particularly sericin) and is used to form fabric that is used to form tissue-supporting prosthetic devices for implantation. The fabrics can carry functional groups, drugs, and other biological reagents. Applications include hernia repair, tissue wall reconstruction, and organ support, such as bladder slings. The silk fibers are arranged in parallel and, optionally, intertwined (e.g., twisted) to form a construct; sericin may be extracted at any point during the formation of the fabric, leaving a construct of silk fibroin fibers having excellent tensile strength and other mechanical properties.
摘要翻译: 丝被纯化以消除免疫原性成分(特别是丝胶蛋白),并且用于形成用于形成用于植入的组织支撑假体装置的织物。 织物可以携带官能团,药物和其他生物试剂。 应用包括疝修补,组织壁重建和器官支撑,如膀胱吊带。 丝纤维平行布置,并且任选地缠结(例如扭曲)以形成构造体; 可以在织物形成期间的任何点提取丝胶蛋白,留下具有优异拉伸强度和其它机械性能的丝素蛋白纤维构建体。
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公开(公告)号:US20120179252A1
公开(公告)日:2012-07-12
申请号:US13426906
申请日:2012-03-22
IPC分类号: A61F2/08
CPC分类号: A61F2/08 , A61F2002/30322 , A61F2250/0026 , D04B1/123 , D10B2509/00
摘要: A knitted prosthetic device has at least two knitted sections, where each knitted section has at least one row of fiber. The knitted prosthetic device also has at least one intra-articular section disposed between the at least two knitted sections. In addition, the at least one intra-articular section has at least one single continuous fiber traversing the at least one intra-articular section and the at least two knitted sections, where the at least one single continuous fiber forms a plurality of traverses extending between the at least two knitted sections. In particular, embodiments may be used as ligament prostheses by anchoring each of the at least two knitted sections to a bone section of a patient. Such embodiments may be constructed from a strong polymer, preferably, but not limited to, silk, where the polymer provides ligament support but bioresorbs as load bearing responsibilities are transferred to tissue resulting from ingrowth.
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公开(公告)号:US08172901B2
公开(公告)日:2012-05-08
申请号:US12052719
申请日:2008-03-20
IPC分类号: A61F2/08
CPC分类号: A61F2/08 , A61F2002/30322 , A61F2250/0026 , D04B1/123 , D10B2509/00
摘要: A knitted prosthetic device has at least two knitted sections, where each knitted section has at least one row of fiber. The knitted prosthetic device also has at least one intra-articular section disposed between the at least two knitted sections. In addition, the at least one intra-articular section has at least one single continuous fiber traversing the at least one intra-articular section and the at least two knitted sections, where the at least one single continuous fiber forms a plurality of traverses extending between the at least two knitted sections. In particular, embodiments may be used as ligament prostheses by anchoring each of the at least two knitted sections to a bone section of a patient. Such embodiments may be constructed from a strong polymer, preferably, but not limited to, silk, where the polymer provides ligament support but bioresorbs as load bearing responsibilities are transferred to tissue resulting from in-growth.
摘要翻译: 针织修复装置具有至少两个针织部,每个针织部具有至少一排纤维。 针织修复装置还具有设置在至少两个针织部之间的至少一个关节部。 另外,所述至少一个关节内部分具有穿过所述至少一个关节内部分和所述至少两个针织部分的至少一个单一连续纤维,其中所述至少一个单一连续纤维形成多个横向延伸 所述至少两个针织部分。 特别地,实施例可以通过将至少两个针织部分中的每一个锚定到患者的骨部分来用作韧带假体。 这样的实施方案可以由强聚合物构成,优选但不限于丝,其中聚合物提供韧带支持,但作为承载责任的生物吸收剂转移到由生长所导致的组织。
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公开(公告)号:US20110184227A1
公开(公告)日:2011-07-28
申请号:US12878757
申请日:2010-09-09
CPC分类号: A61F2/08 , A61F2/0811 , A61F2/12 , A61F2002/0858 , A61F2002/087 , A61F2002/0888 , D04B1/16 , D04B21/16 , D10B2211/22 , D10B2403/0311 , D10B2509/00
摘要: An implantable device for use in tissue and ligament repair comprising at least one knitted section and at least one single continuous fiber traversing the at least one knitted section, the at least one single continuous fiber forming a plurality of traverses extending through the at least one knitted section. The implantable device may comprise at least one single continuous silk fiber. The implantable device is suitable for use in a variety or reconstructive or support applications such as breast reconstruction, mastoplexy, breast augmentation revision, breast augmentation support, standard breast augmentation, chest wall repair, organ support, body contouring, abdominoplasty, facial reconstruction, hernia repair, and pelvic floor repair.
摘要翻译: 一种用于组织和韧带修复的可植入装置,其包括至少一个针织部分和至少一个穿过所述至少一个针织部分的单个连续纤维,所述至少一个单一连续纤维形成多个穿过所述至少一个针织物 部分。 可植入装置可以包括至少一个单一的连续丝纤维。 可植入装置适用于多种或重建或支持应用,如乳房重建,乳腺增生,乳房增大修复,乳房增大支持,标准胸部增大,胸壁修复,器官支撑,身体轮廓,腹部成形术,面部重建,疝气 修复和盆底修复。
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