公开(公告)号：US20180156788A1

公开(公告)日：2018-06-07

申请号：US15577076

申请日：2016-06-30

Applicant: IMEC VZW

Inventor： Willem Van Roy ,  Tim Stakenborg ,  Kris Covens

IPC: G01N33/543 ,  C12Q1/00 ,  C12Q1/6825 ,  G01N33/52

Abstract: A device (1) for sensing an analyte, the device (1) comprises at least a sample inlet (10) for receiving a sample, affinity probes (111) selected to have a preferential binding to the analyte, a transducer (11) sensitive to a characteristic of the analyte and/or a label attached to the analyte, the transducer not being a FET transducer, and a desalting unit (13) for desalting the received sample.

公开(公告)号：US20180149643A1

公开(公告)日：2018-05-31

申请号：US15577311

申请日：2016-06-28

Applicant: IMEC VZW

Inventor： Rita Vos ,  Karolien Jans ,  Tim Stakenborg

IPC: G01N33/543 ,  G01N33/531

CPC classification number: G01N33/54353 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00677 ,  B01J2219/00725 ,  B01J2219/0074 ,  G01N33/531 ,  G01N33/54386

Abstract: A method for immobilizing an analyte-recognizing molecule (1) on a surface (2′) functionalized with chemical groups Y1 suitable for reacting with a chemical group X2 of a coupling molecule (7) to form a reaction product comprising a chemical group Y2 suitable for reacting with the analyte-recognizing molecule (1), the method comprising the steps of: a) Providing the functionalized surface (2′), b) Contacting the functionalized surface (2′) with a solution (6) comprising simultaneously: i) The coupling molecule (7), and ii) The analyte-recognizing molecule (1).