公开(公告)号：US10746731B2

公开(公告)日：2020-08-18

申请号：US15577311

申请日：2016-06-28

Applicant: IMEC VZW

Inventor： Rita Vos ,  Karolien Jans ,  Tim Stakenborg

IPC: G01N33/543 ,  G01N33/531

Abstract: A method for immobilizing an analyte-recognizing molecule (1) on a surface (2′) functionalized with chemical groups Y1 suitable for reacting with a chemical group X2 of a coupling molecule (7) to form a reaction product comprising a chemical group Y2 suitable for reacting with the analyte-recognizing molecule (1), the method comprising the steps of: a) Providing the functionalized surface (2′), b) Contacting the functionalized surface (2′) with a solution (6) comprising simultaneously: i) The coupling molecule (7), and ii) The analyte-recognizing molecule (1).

公开(公告)号：US20180149643A1

公开(公告)日：2018-05-31

申请号：US15577311

申请日：2016-06-28

Applicant: IMEC VZW

Inventor： Rita Vos ,  Karolien Jans ,  Tim Stakenborg

IPC: G01N33/543 ,  G01N33/531

CPC classification number: G01N33/54353 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00677 ,  B01J2219/00725 ,  B01J2219/0074 ,  G01N33/531 ,  G01N33/54386

Abstract: A method for immobilizing an analyte-recognizing molecule (1) on a surface (2′) functionalized with chemical groups Y1 suitable for reacting with a chemical group X2 of a coupling molecule (7) to form a reaction product comprising a chemical group Y2 suitable for reacting with the analyte-recognizing molecule (1), the method comprising the steps of: a) Providing the functionalized surface (2′), b) Contacting the functionalized surface (2′) with a solution (6) comprising simultaneously: i) The coupling molecule (7), and ii) The analyte-recognizing molecule (1).

公开(公告)号：US11971385B2

公开(公告)日：2024-04-30

申请号：US17018368

申请日：2020-09-11

Applicant: IMEC VZW ,  Katholieke Universiteit Leuven, KU LEUVEN R & D

Inventor： Koen Martens ,  Chengxun Liu ,  Camila Dalben Madeira Campos ,  Rita Vos

IPC: G01N27/447

CPC classification number: G01N27/44752 ,  G01N27/44791

Abstract: A cyclic capillary electrophoresis device includes a capillary channel that forms a closed loop. The capillary channel comprises an inner half facing toward a space enclosed by the loop, where the inner half having an inner wall of first charge density, and an outer half facing away from the space enclosed by the loop, where the outer half having an inner wall surface of second charge density. A difference between the first and the second charge densities exists or can be turned on. The difference is configured to create a smaller average electroosmotic flow velocity in the inner half than in the outer half.

公开(公告)号：US20210080427A1

公开(公告)日：2021-03-18

申请号：US17018368

申请日：2020-09-11

Applicant: IMEC VZW ,  Katholieke Universiteit Leuven, KU LEUVEN R & D

Inventor： Koen Martens ,  Chengxun Liu ,  Camila Dalben Madeira Campos ,  Rita Vos

IPC: G01N27/447

Abstract: A cyclic capillary electrophoresis device includes a capillary channel that forms a closed loop. The capillary channel comprises an inner half facing toward a space enclosed by the loop, where the inner half having an inner wall of first charge density, and an outer half facing away from the space enclosed by the loop, where the outer half having an inner wall surface of second charge density. A difference between the first and the second charge densities exists or can be turned on. The difference is configured to create a smaller average electroosmotic flow velocity in the inner half than in the outer half.