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40 条记录 (耗时 0.032 秒)

    Counteracting bioprosthetic calcification
    32.
    发明授权
    Counteracting bioprosthetic calcification 失效
    抵制生物假体钙化

    公开(公告)号：US07156881B2

    公开(公告)日：2007-01-02

    申请号：US10336857

    申请日：2003-01-06

    申请人： Robert J. Levy ,  Ivan Alferiev

    发明人： Robert J. Levy ,  Ivan Alferiev

    IPC分类号： A61F2/02

    CPC分类号： A61K31/663 ,  A61L27/3687 ,  A61L27/54 ,  A61L31/16 ,  A61L2400/02

    摘要： Adapting crosslinking with triglycidyl amine (TGA) to incorporate the use of a particular type of anti-calcification agent provides a broad-reaching solution to the problem in vivo bioprosthesis calcification. The anti-calcification agent in question includes a polyphosphonate compound that contains a functional group, which serves as a reaction site between the polyphosphonate and a polyepoxide. The functional group is reactive enough to dominate the reaction between the polyphosphonate and the polyepoxide, thereby excluding the chelating oxygen atoms of polyphosphonate from the reaction, protecting their anti-calcification ability. Furthermore, the high reactivity of the functional group allows the polyphosphonate to attach to the polyepoxide more completely, which improves the calcification resistance of bioprosthetic material with which the polyepoxide is crosslinked.

    摘要翻译： 使用三缩水甘油胺（TGA）进行交联以引入特定类型的抗钙化剂的使用为体内生物假体钙化提供了广泛的解决方案。 所讨论的抗钙化剂包括含有官能团的聚膦酸酯化合物，其用作聚膦酸盐和聚环氧化物之间的反应位点。 官能团反应性足以支配聚膦酸酯与聚环氧化物之间的反应，从反应中排除多膦酸的螯合氧原子，保护其抗钙化能力。 此外，官能团的高反应性允许聚膦酸盐更加完全地附着到聚环氧化物上，这提高了聚环氧化物交联的生物纤维材料的耐钙性。

    Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same
    33.
    发明授权
    Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same 失效
    在生物系统中表现出增强的稳定性的衍生的聚氨酯组合物及其制备方法

    公开(公告)号：US06689861B2

    公开(公告)日：2004-02-10

    申请号：US09985316

    申请日：2001-11-02

    申请人： Robert J. Levy ,  Ivan Alferiev

    发明人： Robert J. Levy ,  Ivan Alferiev

    IPC分类号： C08G1883

    CPC分类号： C08G18/4854 ,  C08G18/6674 ,  C08G18/836

    摘要： The invention relates to methods of making polyurethane derivatives which can be readily further derivatized using stabilizing agents such as anti-calcification agents, anti-thrombogenesis agents, and chemical and mechanical degradation-inhibiting agents. The invention also includes methods of making polyurethane derivatives so further derivatized and to polyurethanes derivatives made using such methods.

    摘要翻译： 本发明涉及制备聚氨酯衍生物的方法，其可以使用稳定剂如抗钙化剂，抗血栓形成剂和化学和机械降解抑制剂容易地进一步衍生化。 本发明还包括制备如此进一步衍生的聚氨酯衍生物和使用这些方法制备的聚氨酯衍生物的方法。

    Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same
    34.
    发明授权
    Derivatized polyurethane compositions which exhibit enhanced stability in biological systems and methods of making the same 有权
    在生物系统中表现出增强的稳定性的衍生的聚氨酯组合物及其制备方法

    公开(公告)号：US06320011B1

    公开(公告)日：2001-11-20

    申请号：US09620857

    申请日：2000-07-21

    申请人： Robert J. Levy ,  Ivan Alferiev

    发明人： Robert J. Levy ,  Ivan Alferiev

    IPC分类号： C08G1883

    CPC分类号： C08G18/4854 ,  C08G18/6674 ,  C08G18/836

    摘要： The invention relates to methods of making polyurethane derivatives which can be readily further derivatized using stabilizing agents such as anti-calcification agents, anti-thrombogenesis agents, and chemical and mechanical degradation-inhibiting agents. The invention also includes methods of making polyurethane derivatives so further derivatized and to polyurethanes derivatives made using such methods.

    摘要翻译： 本发明涉及制备聚氨酯衍生物的方法，其可以使用稳定剂如抗钙化剂，抗血栓形成剂和化学和机械降解抑制剂容易地进一步衍生化。 本发明还包括制备如此进一步衍生的聚氨酯衍生物和使用这些方法制备的聚氨酯衍生物的方法。

    Gene and Cell Delivery Self Expanding Polymer Stents
    35.
    发明申请
    Gene and Cell Delivery Self Expanding Polymer Stents 审中-公开
    基因和细胞递送自扩张聚合物支架

    公开(公告)号：US20070293927A1

    公开(公告)日：2007-12-20

    申请号：US10589711

    申请日：2004-04-16

    申请人： Ko Frank ,  Robert Levy ,  Ivan Alferiev ,  Ilia Fishbein

    发明人： Ko Frank ,  Robert Levy ,  Ivan Alferiev ,  Ilia Fishbein

    IPC分类号： A61F2/06

    CPC分类号： A61F2/90 ,  A61F2250/0067 ,  A61L31/16 ,  A61L2300/80

    摘要： A device having polymeric filaments, wherein at least one of the filaments includes at least one groove for slidably retaining at least one other filament, such that the device is adapted to revert to a tubular lattice structure when allowed to expand from a collapsed state. A device as described above and further including a biologically active function, wherein the polymeric filaments of the device include an agent having a reactive group or a fiber adapted to covalently react with a biomaterial. Thus, the device of the invention has an active structural function such as the ability to regain a shape and, optionally, a biologically active function such as the ability to deliver a biomaterial to an organism or a cell. A process of manufacturing the device is also described.

    摘要翻译： 一种具有聚合物长丝的装置，其中至少一根长丝包括至少一个用于可滑动地保持至少一个其它细丝的凹槽，使得该装置适于在允许从折叠状态膨胀时回复到管状格子结构。 如上所述的装置并且还包括生物活性功能，其中所述装置的聚合长丝包括具有反应性基团的试剂或适于与生物材料共价反应的纤维。 因此，本发明的装置具有活性结构功能，例如恢复形状和任选的生物活性功能的能力，例如将生物材料递送到生物体或细胞的能力。 还描述了制造该装置的过程。

    Biodegradable linkers for molecular therapies
    36.
    发明申请
    Biodegradable linkers for molecular therapies 有权
    用于分子疗法的生物可降解接头

    公开(公告)号：US20070298066A1

    公开(公告)日：2007-12-27

    申请号：US11799861

    申请日：2007-05-03

    申请人： Ivan Alferiev ,  Robert Levy ,  Ilia Fishbein

    发明人： Ivan Alferiev ,  Robert Levy ,  Ilia Fishbein

    IPC分类号： A61K47/48 ,  A61K35/00 ,  A61K48/00 ,  A61K9/10 ,  A61K38/00

    CPC分类号： A61K47/6957 ,  A61K47/6901 ,  C12N2799/022

    摘要： A method and a composition for delivery of a biomaterial to an animal cell or a tissue, the composition includes (a) a biomaterial; (b) a biodegradable cross-linker portion having a hydrolyzable bond, wherein the biodegradable cross-linker portion is covalently bound to the biomaterial; and (c) a substrate, wherein the substrate is covalently bound to the biodegradable cross-linker portion, provided that the biodegradable cross-linker is adapted to hydrolyze by breaking the hydrolyzable bond and thereby release and deliver the biomaterial. A process of making the composition is also provided.

    摘要翻译： 用于将生物材料递送到动物细胞或组织的方法和组合物，所述组合物包括（a）生物材料; （b）具有可水解键的可生物降解的交联剂部分，其中所述可生物降解的交联剂部分与所述生物材料共价结合; 并且（c）底物，其中所述底物共价结合到所述可生物降解的交联剂部分，条件是所述可生物降解的交联剂适于通过破坏所述可水解键从而水解，从而释放和递送所述生物材料。 还提供了制备组合物的方法。

    Degradation resistant polyurethanes
    37.
    发明申请
    Degradation resistant polyurethanes 审中-公开
    抗降解聚氨酯

    公开(公告)号：US20060063894A1

    公开(公告)日：2006-03-23

    申请号：US11233149

    申请日：2005-09-21

    申请人： Ivan Alferiev ,  Robert Levy ,  Stanley Stachelek

    发明人： Ivan Alferiev ,  Robert Levy ,  Stanley Stachelek

    IPC分类号： C08G18/00

    CPC分类号： C08G18/83

    摘要： A degradation resistant polyurethane and methods of making and using thereof wherein the degradation resistant polyurethane has a modified hard segment which includes a urethane nitrogen and an antioxidant substituent pendant from the urethane nitrogen.

    摘要翻译： 耐降解聚氨酯及其制造和使用方法，其中耐劣化聚氨酯具有改性的硬链段，其包括氨基甲酸酯氮和来自聚氨酯氮的侧链的抗氧化剂取代基。

    Biodegradable crosslinking strategies using triglycidyl amine (TGA)
    39.
    发明申请
    Biodegradable crosslinking strategies using triglycidyl amine (TGA) 审中-公开
    使用三缩水甘油胺（TGA）的生物降解交联策略

    公开(公告)号：US20050244460A1

    公开(公告)日：2005-11-03

    申请号：US11119063

    申请日：2005-04-29

    申请人： Ivan Alferiev ,  Robert Levy

    发明人： Ivan Alferiev ,  Robert Levy

    IPC分类号： A61F2/02 ,  C08G65/04

    CPC分类号： C08G59/3227 ,  A61L27/34 ,  A61L27/3683 ,  A61L27/50 ,  A61L27/58 ,  A61L31/10 ,  A61L31/14 ,  A61L31/148

    摘要： The invention relates to implantable biodegradable bioprostheses and methods for making and using the bioprostheses. The implantable biodegradable bioprosthesis includes biomolecules having a reactive moiety and optionally a reactive group; and a biodegradable cross-linking moiety having (a) at least two linking moieties, wherein the at least two linking moieties are non-biodegradable and (b) a spacer, wherein the spacer is biodegradable and is in communication with the at least two linking moieties, provided that the biodegradable cross-linking moiety is artificial and is covalently bound to the reactive moiety. The implantable bioprosthesis is adapted to sufficiently degrade upon exposure to a cell or an enzyme to permit an expansion of the implantable bioprosthesis.

    摘要翻译： 本发明涉及可植入的可生物降解的生物预处理和生产和使用生物预处理的方法。 可植入的可生物降解的生物假体包括具有反应性部分和任选的反应性基团的生物分子; 和（a）至少两个连接部分的生物可降解的交联部分，其中所述至少两个连接部分是不可生物降解的，和（b）间隔物，其中所述间隔物是可生物降解的并且与所述至少两个连接 部分，条件是可生物降解的交联部分是人造的并且与反应性部分共价结合。 可植入生物假体适于在暴露于细胞或酶时充分降解以允许可植入生物假体的扩张。