公开(公告)号：US20110203392A1

公开(公告)日：2011-08-25

申请号：US12709414

申请日：2010-02-19

Applicant: James Sinclair ,  B. Albert Griffin ,  Minh Vuong

Inventor： James Sinclair ,  B. Albert Griffin ,  Minh Vuong

IPC: G01N1/20

CPC classification number: G01N9/02 ,  G01N1/20

Abstract: Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.

Abstract translation: 提供了散装材料如粉末的在线取样方法和装置。 可以使用本文所述的方法和装置绘制的样品来确定材料的体积密度。 采样材料的方法的一个实施例允许材料流过采样室，封闭采样室下方的材料流，通过采样室建立一列材料，移动采样室以移除一片 柱中的材料，并将切片材料放入样品容器中。 在另一个实施例中提供用于取样材料的装置。 该装置包括入口，与入口对准的出口和样品收集器。 样品收集器可以包括至少一个通孔，并且被配置为移动，使得至少一个通孔可以移动进入和离开与入口和出口对齐。

公开(公告)号：US20090281911A1

公开(公告)日：2009-11-12

申请号：US12436259

申请日：2009-05-06

Applicant: James Sinclair ,  James O'Hagan ,  Edward R. Howorka ,  Jain Neena

Inventor： James Sinclair ,  James O'Hagan ,  Edward R. Howorka ,  Jain Neena

IPC: G06Q30/00

CPC classification number: G06Q40/04 ,  G06Q30/0601

Abstract: An anonymous trading system includes a prime broker facility that allows a third party to trade on behalf of an institution. A deal is executed between the third party and a counter-party and a further deal is then executed between the third party and the party on whose behalf it has traded. The second deal may be for the same amount as the first deal or may be altered to include the third party's fee for conducting the first deal. Clients of the third party have prices available to them for trades made via the third party which are displayed at their trader terminals. The client sees that a better price is available though the third party than by dealing direct and selects to conduct a deal through the third party.

公开(公告)号：US20060287523A1

公开(公告)日：2006-12-21

申请号：US11391675

申请日：2006-03-29

Applicant: Claude Wischik ,  Janet Rickard ,  Charles Harrington ,  David Horsley ,  John Storey ,  Colin Marshall ,  James Sinclair ,  Han Tan

Inventor： Claude Wischik ,  Janet Rickard ,  Charles Harrington ,  David Horsley ,  John Storey ,  Colin Marshall ,  James Sinclair ,  Han Tan

IPC: C07D279/18

CPC classification number: C09B19/02 ,  C07D279/18

Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diaminophenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methythioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (NOS); nitrosyl reduction (NR); thiosulfonic acid formation (TSAF); oxidative coupling (OC); Cr(VI) reduction (CR); isolation and purification of zwitterionic intermediate (IAPOZI); ring closure (RC); chloride salt formation (CSF); one of: sulphide treatment (ST); dimethyldithiocarbamate treatment (DT); carbonate treatment (CT); ethylenediaminetetraacetic acid treatment (EDTAT); organic extraction (OE); and recrystallisation (RX). The present invention also pertains to the resulting (high purity) compounds, compositions comprising them (e.g., tablets, capsules), and their use in methods of inactivating pathogens, and methods of medical treatment and diagnosis, etc., for example, for tauopathies, Alzheimer's disease (AD), skin cancer, melanoma, viral diseases, bacterial diseases, or protozoal diseases.

Abstract translation: 本发明一般涉及化学合成和纯化领域，更具体地涉及合成和纯化某些3,7-二氨基吩噻嗪-5-肟化合物（本文中称为“二氨基吩噻嗪鎓化合物”）的方法，包括氯化铁偶氮（MTC）（ 也称为亚甲基蓝）。 在一个实施方案中，该方法包括以下步骤：按顺序：亚硝基化（NOS）; 亚硝酰还原（NR）; 硫代磺酸形成（TSAF）; 氧化偶合（OC）; Cr（VI）还原（CR）; 两性离子中间体（IAPOZI）的分离和纯化; 闭环（RC）; 氯化物盐形成（CSF）; 一种：硫化物处理（ST）; 二甲基二硫代氨基甲酸酯处理（DT）; 碳酸盐处理（CT）; 乙二胺四乙酸处理（EDTAT）; 有机萃取（OE）; 和重结晶（RX）。 本发明还涉及所得的（高纯度）化合物，包含它们的组合物（例如片剂，胶囊）及其在灭活病原体的方法中的用途，以及治疗和诊断方法等，例如对于tau蛋白病 ，阿尔茨海默病（AD），皮肤癌，黑素瘤，病毒性疾病，细菌性疾病或原生动物疾病。

公开(公告)号：US20050221274A1

公开(公告)日：2005-10-06

申请号：US10815176

申请日：2004-03-31

Applicant: Paul Negulescu ,  Alec Harootunian ,  Philip Salzmann ,  Javier Flores ,  James Sinclair ,  Minh Vuong ,  Ashvani Singh ,  Fred VanGoor

Inventor： Paul Negulescu ,  Alec Harootunian ,  Philip Salzmann ,  Javier Flores ,  James Sinclair ,  Minh Vuong ,  Ashvani Singh ,  Fred VanGoor

IPC: B01L3/00 ,  C12M1/34 ,  C12M3/06 ,  G01N33/487 ,  C12Q1/00

CPC classification number: B01L3/5085 ,  B01L3/50255 ,  B01L2300/0645 ,  B01L2300/0829

Abstract: A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber.”

Abstract translation: 用于表征细胞的生物学性质的装置可以包括多个双隔室测定室，其中每个室的隔室被离子可以流过的细胞层分开。 在存在或不存在实验化合物的情况下，细胞层的生物学性质可以通过测量该层的电梯度来确定。 这种类型的单室双腔室可以称为“尿素室”。