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公开(公告)号：US20070072257A1
公开(公告)日：2007-03-29
申请号：US11605814
申请日：2006-11-29
申请人： Paul Negulescu , Alec Harootunian , Philip Salzmann , Javier Flores , James Sinclair , Minh Vuong , Ashvani Singh , Fred VanGoor
发明人： Paul Negulescu , Alec Harootunian , Philip Salzmann , Javier Flores , James Sinclair , Minh Vuong , Ashvani Singh , Fred VanGoor
CPC分类号： B01L3/5085 , B01L3/50255 , B01L2300/0645 , B01L2300/0829
摘要： A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber.”
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公开(公告)号：US20050221274A1
公开(公告)日：2005-10-06
申请号：US10815176
申请日：2004-03-31
申请人： Paul Negulescu , Alec Harootunian , Philip Salzmann , Javier Flores , James Sinclair , Minh Vuong , Ashvani Singh , Fred VanGoor
发明人： Paul Negulescu , Alec Harootunian , Philip Salzmann , Javier Flores , James Sinclair , Minh Vuong , Ashvani Singh , Fred VanGoor
IPC分类号： B01L3/00 , C12M1/34 , C12M3/06 , G01N33/487 , C12Q1/00
CPC分类号： B01L3/5085 , B01L3/50255 , B01L2300/0645 , B01L2300/0829
摘要： A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber.”
摘要翻译： 用于表征细胞的生物学性质的装置可以包括多个双隔室测定室，其中每个室的隔室被离子可以流过的细胞层分开。 在存在或不存在实验化合物的情况下，细胞层的生物学性质可以通过测量该层的电梯度来确定。 这种类型的单室双腔室可以称为“尿素室”。
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公开(公告)号：US08101767B2
公开(公告)日：2012-01-24
申请号：US12351401
申请日：2009-01-09
申请人： Sara Hadida Ruah , Anna Hazlewood , Peter D. J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人： Sara Hadida Ruah , Anna Hazlewood , Peter D. J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
IPC分类号： C07D215/38
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20050176789A1
公开(公告)日：2005-08-11
申请号：US10936448
申请日：2004-09-07
申请人： Sara Hadida Ruah , Mark Miller , Ashvani Singh , Thomas Cleveland , Lewis Makings , Matthew Hamilton , Peter Grootenhuis
发明人： Sara Hadida Ruah , Mark Miller , Ashvani Singh , Thomas Cleveland , Lewis Makings , Matthew Hamilton , Peter Grootenhuis
IPC分类号： A61K31/426 , A61K31/427 , A61P43/00 , C07D263/48 , C07D277/46 , C07D277/82 , C07D417/02 , C07D417/04 , C07D417/06 , C07D417/12
CPC分类号： A61K31/426 , A61K31/4439 , A61K31/454 , A61K31/5377 , C07D263/48 , C07D277/46 , C07D277/82 , C07D295/15 , C07D417/04 , C07D417/06 , C07D417/12 , G01N33/5076
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运体或其片段的调节剂，包括CF跨膜调节剂（“CFTR”），其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20090227797A1
公开(公告)日：2009-09-10
申请号：US12351401
申请日：2009-01-09
申请人： Sara Hadida Ruah , Anna Hazlewood , Peter D.J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人： Sara Hadida Ruah , Anna Hazlewood , Peter D.J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
IPC分类号： C07D401/12 , C07D417/12 , C07D413/12
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：US20080071095A1
公开(公告)日：2008-03-20
申请号：US11841646
申请日：2007-08-20
申请人： Sara Hadida-Ruah , Anna Hazelwood , Peter Grootenhuis , Fred Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人： Sara Hadida-Ruah , Anna Hazelwood , Peter Grootenhuis , Fred Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
IPC分类号： C07C215/76 , C07C69/96 , C07D209/14 , C07D209/16 , C07D311/76
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20060074075A1
公开(公告)日：2006-04-06
申请号：US11165818
申请日：2005-06-24
申请人： Sara Hadida-Ruah , Anna Hazelwood , Peter Grootenhuis , Fred Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人： Sara Hadida-Ruah , Anna Hazelwood , Peter Grootenhuis , Fred Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
IPC分类号： A61K31/55 , A61K31/5415 , A61K31/538 , A61K31/5377 , A61K31/496 , A61K31/4747 , A61K31/4709 , A61K31/4704 , C07D417/02 , C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
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公开(公告)号：US20050148648A1
公开(公告)日：2005-07-07
申请号：US10961485
申请日：2004-10-08
IPC分类号： A61K31/00 , A61K31/335 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/495 , A61K45/06 , C07C233/11 , C07C233/22 , C07C233/60 , C07C233/65 , C07C233/73 , C07C235/34 , C07C235/46 , C07C235/48 , C07C307/00 , C07C311/16 , C07C311/17 , C07C323/60 , C07D209/42 , C07D213/82 , C07D215/54 , C07D215/56 , C07D217/26 , C07D231/14 , C07D231/56 , C07D237/28 , C07D261/20 , C07D307/68 , C07D307/85 , C07D307/87 , C07D333/32 , C07D333/70 , C07D407/12 , C07D409/02 , A61K31/343 , A61K31/381 , A61K31/416 , C07D45/02
CPC分类号： C07D307/87 , A61K31/00 , A61K31/335 , A61K31/38 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/495 , A61K45/06 , C07C233/22 , C07C233/60 , C07C233/65 , C07C233/73 , C07C235/34 , C07C235/46 , C07C235/48 , C07C311/16 , C07C311/17 , C07C323/60 , C07C2601/08 , C07D209/42 , C07D213/82 , C07D215/54 , C07D217/26 , C07D231/14 , C07D231/56 , C07D237/28 , C07D261/20 , C07D307/68 , C07D307/85 , C07D333/32 , C07D333/70 , C07D407/12
摘要： The present invention provides compounds of Formula I useful as modulators of ABC transporter activity, or a pharmaceutically acceptable salt thereof, wherein RB, n, B, RC, RD, RE, A, and Z are described generally and in classes and subclasses below. The present invention also provides pharmaceutical compositions, methods and kits associated with Formula I, useful for as modulators, and for the treatments of disease and disease conditions associated with ABC transporter proteins.
摘要翻译： 本发明提供可用作ABC转运蛋白活性调节剂的式I化合物或其药学上可接受的盐，其中R B，N，B，R C， SUP> D ，R E，A和Z一般地在下面的类和子类中描述。 本发明还提供了与式I相关的药物组合物，方法和试剂盒，其用作调节剂，以及用于治疗与ABC转运蛋白相关的疾病和疾病状况。
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公开(公告)号：US08324242B2
公开(公告)日：2012-12-04
申请号：US12351447
申请日：2009-01-09
申请人： Sara Hadida Ruah , Anna Hazlewood , Peter D. J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
发明人： Sara Hadida Ruah , Anna Hazlewood , Peter D. J. Grootenhuis , Fredrick Van Goor , Ashvani Singh , Jinglan Zhou , Jason McCartney
CPC分类号： C07D471/10 , A61K8/4926 , A61K31/04 , A61K31/136 , A61K31/265 , A61K31/27 , A61K31/277 , A61K31/352 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/44 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4747 , A61K31/538 , A61K31/5415 , A61K31/55 , A61K45/06 , C07C205/11 , C07C205/58 , C07C209/00 , C07C211/17 , C07C211/50 , C07C211/52 , C07C215/28 , C07C215/70 , C07C215/76 , C07C215/78 , C07C217/76 , C07C217/80 , C07C217/84 , C07C219/34 , C07C229/52 , C07C255/58 , C07C271/20 , C07C311/08 , C07C311/39 , C07C2601/14 , C07C2601/18 , C07C2602/10 , C07C2603/74 , C07D209/04 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/94 , C07D209/96 , C07D213/20 , C07D213/73 , C07D215/227 , C07D215/233 , C07D215/38 , C07D215/56 , C07D217/04 , C07D217/06 , C07D223/16 , C07D265/36 , C07D279/16 , C07D311/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , G01N33/48728 , G01N33/5035 , G01N33/566 , G01N33/6872 , G01N2333/705
摘要： The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
摘要翻译： 本发明涉及ATP结合盒（ABC）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂，其组合物及其方法。 本发明还涉及使用这种调节剂治疗ABC转运蛋白介导的疾病的方法。
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公开(公告)号：US20110177999A1
公开(公告)日：2011-07-21
申请号：US12672664
申请日：2008-08-07
IPC分类号： A61K38/12 , C12N5/071 , A61K31/517 , A61K31/7048 , A61K31/4184 , A61K31/5415 , A61K31/553 , A61K31/138 , A61K31/343 , A61K31/4545 , A61K31/135 , A61K31/5377 , A61K31/40 , A61K31/496 , A61K31/4152 , A61K31/4709 , A61K31/52 , A61K31/58 , A61K31/397 , A61K31/47 , A61P11/00
CPC分类号： A61K31/137 , A61K31/138 , A61K31/343 , A61K31/351 , A61K31/4184 , A61K31/4545 , A61K31/517 , A61K31/5415 , A61K31/553
摘要： The present invention relates to therapeutic combinations and kits useful in treating CFTR-related diseases, such as cystic fibrosis.
摘要翻译： 本发明涉及可用于治疗CFTR相关疾病如囊性纤维化的治疗组合和试剂盒。
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