利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

79 条记录 (耗时 0.058 秒)

    Aniline derivatives, their manufacture and use as pharmaceutical agents
    33.
    发明授权
    Aniline derivatives, their manufacture and use as pharmaceutical agents 失效
    苯胺衍生物，其制造和用作药剂

    公开(公告)号：US07345067B2

    公开(公告)日：2008-03-18

    申请号：US10858297

    申请日：2004-06-01

    申请人： Jean Ackermann ,  Johannes Aebi ,  Alfred Binggeli ,  Uwe Grether ,  Georges Hirth ,  Bernd Kuhn ,  Hans-Peter Maerki ,  Markus Meyer ,  Peter Mohr ,  Matthew Blake Wright

    发明人： Jean Ackermann ,  Johannes Aebi ,  Alfred Binggeli ,  Uwe Grether ,  Georges Hirth ,  Bernd Kuhn ,  Hans-Peter Maerki ,  Markus Meyer ,  Peter Mohr ,  Matthew Blake Wright

    IPC分类号： A61K31/426 ,  C07D277/20

    CPC分类号： C07D277/28 ,  C07D263/32

    摘要： This invention relates to compounds of the formula wherein X is N and Y is S or O; or X is S or O and Y is N; R1 is hydrogen or C1-7-alkyl; R2 and R3 independently from each other are selected from the group consisting of hydrogen, C1-7-alkyl and C1-7-alkoxy; R4, R5, R6, and R7 independently from each other are selected from the group consisting of hydrogen, C1-7-alkyl, C3-7-cycloalkyl, halogen, C1-7-alkoxy, C1-7-alkyl-C1-7-alkoxy-C1-7-alkyl, C2-7-alkenyl, C2-7-alkinyl, fluoro-C1-7-alkyl and cyano; R8 is selected from the group consisting of hydrogen, C1-7-alkyl, C3-7-cycloalkyl and fluoro-C1-7-alkyl; R9 is selected from the group consisting of hydrogen, C1-7-alkyl, C2-7-alkinyl, C3-7-cycloalkyl and fluoro-C1-7-alkyl; R10 is selected from the group consisting of hydrogen, C1-7-alkyl, C2-7-alkinyl, C3-7-cycloalkyl and fluoro-C1-7-alkyl; R11 is aryl or heteroaryl; N is 0, 1 or 2; and all enantiomers and pharmaceutically acceptable salts and/or esters thereof and their use as PPAR activators.

    摘要翻译： 本发明涉及下式的化合物其中X是N，Y是S或O; 或X为S或O，Y为N; R 1是氢或C 1-7 - 烷基; R 2和R 3彼此独立地选自氢，C 1-7 - 烷基和C 1-4烷基， 1-7-烷氧基; R 4，R 5，R 6，R 6和R 7彼此独立地选自： 的氢，C 1-7 - 烷基，C 3-7 - 环烷基，卤素，C 1-7 - 烷氧基，C 烯基，C 2-7 - 炔基，氟-C 1-7 - 烷基和氰基; R 8选自氢，C 1-7 - 烷基，C 3-7 - 环烷基和氟-C 1-4烷基， 烷基; R 9选自氢，C 1-7 - 烷基，C 2-7 - 炔基，C 1〜 3-7环烷基和氟-C 1-7 - 烷基; R 10选自氢，C 1-7 - 烷基，C 2-7 - 炔基，C 1〜 3-7环烷基和氟-C 1-7 - 烷基; R 11是芳基或杂芳基; N为0,1或2; 及其所有对映异构体及其药学上可接受的盐和/或酯及其作为PPAR活化剂的用途。