公开(公告)号：US20110301576A1

公开(公告)日：2011-12-08

申请号：US13209328

申请日：2011-08-12

申请人： Scott D. Lautenbach ,  Pedro E. de la Serna ,  Pauline C. Zamora ,  Michael A. DesJardin

发明人： Scott D. Lautenbach ,  Pedro E. de la Serna ,  Pauline C. Zamora ,  Michael A. DesJardin

IPC分类号： A61M31/00 ,  B23P11/00

CPC分类号： A61K9/0004 ,  A61K38/21 ,  Y10T29/49236 ,  Y10T29/494 ,  Y10T137/0402

摘要： An osmotic delivery system flow modulator includes an outer shell constructed and arranged for positioning in an opening, an inner core inserted in the outer shell, and a fluid channel having a spiral shape defined between the outer shell and the inner core. The fluid channel is adapted for delivery of an active agent formulation from the reservoir of the osmotic delivery system.

摘要翻译： 渗透输送系统流调节器包括构造和布置成定位在开口中的外壳，插入外壳中的内芯，以及限定在外壳和内芯之间的具有螺旋形状的流体通道。 流体通道适于从渗透递送系统的储存器输送活性剂制剂。

公开(公告)号：US20110166554A1

公开(公告)日：2011-07-07

申请号：US12930950

申请日：2011-01-19

申请人： Thomas R. Alessi ,  Michael A. DesJardin ,  Stan Lam ,  Scott D. Lautenbach ,  Pauline C. Zamora

发明人： Thomas R. Alessi ,  Michael A. DesJardin ,  Stan Lam ,  Scott D. Lautenbach ,  Pauline C. Zamora

IPC分类号： A61M31/00 ,  B23P17/04

CPC分类号： F16J9/26 ,  A61K9/0004 ,  A61K9/0024 ,  A61M5/14276 ,  A61M5/14526 ,  A61M2005/14513 ,  A61M2205/0216 ,  F16J9/28 ,  Y10T29/49826

摘要： An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.

公开(公告)号：US07682356B2

公开(公告)日：2010-03-23

申请号：US11890836

申请日：2007-08-08

申请人： Thomas R. Alessi ,  Michael A. DesJardin ,  Stan Lam ,  Scott D. Lautenbach ,  Pauline C. Zamora

发明人： Thomas R. Alessi ,  Michael A. DesJardin ,  Stan Lam ,  Scott D. Lautenbach ,  Pauline C. Zamora

IPC分类号： A61K9/22

CPC分类号： F16J9/26 ,  A61K9/0004 ,  A61K9/0024 ,  A61M5/14276 ,  A61M5/14526 ,  A61M2005/14513 ,  A61M2205/0216 ,  F16J9/28 ,  Y10T29/49826

摘要： An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.

公开(公告)号：US07112335B2

公开(公告)日：2006-09-26

申请号：US11219960

申请日：2005-09-06

申请人： Scott D. Lautenbach

发明人： Scott D. Lautenbach

IPC分类号： A61F2/00 ,  A61K9/22

CPC分类号： A61K9/48 ,  A61K9/0004 ,  A61M31/002 ,  A61M2005/14513

摘要： An osmotic pump having a minimally compliant, volume-efficient piston positioned within a capsule is provided. The capsule has an interior surface, a beneficial agent, and an osmotic agent. The piston is movable with respect to an interior surface of the capsule, and defines a movable seal with the interior surface of the capsule. The movable seal separates the osmotic agent from the beneficial agent. The piston has a length-to-total-diameter ratio of about 1.1:1 and a core-diameter-to-total-diameter ratio of about 0.9:1. The piston enables greater beneficial agent and/or osmotic agent payload without increasing the size of the capsule. The osmotic agent imbibes liquid from a surrounding environment through a semipermeable body to cause the piston to move and, in turn, cause delivery of the beneficial agent from the capsule.

摘要翻译： 提供了一种具有位于胶囊内的最小顺应性体积效率的活塞的渗透泵。 胶囊具有内表面，有益剂和渗透剂。 活塞可相对于胶囊的内表面移动，并且与胶囊的内表面限定可移动的密封。 可移动密封件将渗透剂与有益剂分离。 活塞具有约1.1:1的长度与总直径之比和约0.9:1的芯直径与总直径之比。 该活塞能够增加更大的有益剂和/或渗透剂有效载荷，而不增加胶囊的尺寸。 渗透剂通过半渗透体吸收来自周围环境的液体，引起活塞移动，从而使有益剂从胶囊输送。