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公开(公告)号：US20100185184A1
公开(公告)日：2010-07-22
申请号：US12658570
申请日：2010-02-09
CPC分类号： F16J9/26 , A61K9/0004 , A61K9/0024 , A61M5/14276 , A61M5/14526 , A61M2005/14513 , A61M2205/0216 , F16J9/28 , Y10T29/49826
摘要： An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.
摘要翻译： 公开了用于将活性剂制剂递送到流体环境的渗透递送系统。 渗透递送系统通常包括储存器，其具有包含活性剂制剂的内腔和渗透剂制剂以及位于内腔中的活塞组件，以将活性剂制剂与渗透剂制剂隔离。 活塞组件通常包括构造和布置成用于定位在内腔中的主体。 主体通常由例如耐有机溶剂浸出的聚合材料制成。 在一个实施例中，主体是一个柱状体，其具有在其远端处的边缘，用于接合和密封储存器的壁，并且活塞组件还包括保持在柱状体的远端处的弹簧，用于偏置 柱状体抵靠水库的墙壁。
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公开(公告)号：US08801700B2
公开(公告)日：2014-08-12
申请号：US12930950
申请日：2011-01-19
IPC分类号： A61K9/22
CPC分类号： F16J9/26 , A61K9/0004 , A61K9/0024 , A61M5/14276 , A61M5/14526 , A61M2005/14513 , A61M2205/0216 , F16J9/28 , Y10T29/49826
摘要： An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.
摘要翻译： 公开了用于将活性剂制剂递送到流体环境的渗透递送系统。 渗透递送系统通常包括储存器，其具有包含活性剂制剂的内腔和渗透剂制剂以及位于内腔中的活塞组件，以将活性剂制剂与渗透剂制剂隔离。 活塞组件通常包括构造和布置成用于定位在内腔中的主体。 主体通常由例如耐有机溶剂浸出的聚合材料制成。 在一个实施例中，主体是一个柱状体，其具有在其远端处的边缘，用于接合和密封储存器的壁，并且活塞组件还包括保持在柱状体的远端处的弹簧，用于偏置 柱状体抵靠水库的墙壁。
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公开(公告)号：US07879028B2
公开(公告)日：2011-02-01
申请号：US12658570
申请日：2010-02-09
IPC分类号： A61K9/22
CPC分类号： F16J9/26 , A61K9/0004 , A61K9/0024 , A61M5/14276 , A61M5/14526 , A61M2005/14513 , A61M2205/0216 , F16J9/28 , Y10T29/49826
摘要： An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.
摘要翻译： 公开了用于将活性剂制剂递送到流体环境的渗透递送系统。 渗透递送系统通常包括储存器，其具有包含活性剂制剂的内腔和渗透剂制剂以及位于内腔中的活塞组件，以将活性剂制剂与渗透剂制剂隔离。 活塞组件通常包括构造和布置成用于定位在内腔中的主体。 主体通常由例如耐有机溶剂浸出的聚合材料制成。 在一个实施例中，主体是具有在其远端处的边缘的柱状体，用于接合和密封储存器的壁，并且活塞组件还包括保持在柱状体的远端处的弹簧，用于偏置 柱状体抵靠水库的墙壁。
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公开(公告)号：US20110166554A1
公开(公告)日：2011-07-07
申请号：US12930950
申请日：2011-01-19
CPC分类号： F16J9/26 , A61K9/0004 , A61K9/0024 , A61M5/14276 , A61M5/14526 , A61M2005/14513 , A61M2205/0216 , F16J9/28 , Y10T29/49826
摘要： An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.
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公开(公告)号：US07682356B2
公开(公告)日：2010-03-23
申请号：US11890836
申请日：2007-08-08
IPC分类号： A61K9/22
CPC分类号： F16J9/26 , A61K9/0004 , A61K9/0024 , A61M5/14276 , A61M5/14526 , A61M2005/14513 , A61M2205/0216 , F16J9/28 , Y10T29/49826
摘要： An osmotic delivery system is disclosed for delivering an active agent formulation to a fluid environment. The osmotic delivery system typically comprises a reservoir having a lumen that contains the active agent formulation and an osmotic agent formulation and a piston assembly positioned in the lumen to isolate the active agent formulation from the osmotic agent formulation. The piston assembly typically comprises a body constructed and arranged for positioning in the lumen. The body is typically made of a polymeric material that is, for example, resistant to leaching in an organic solvent. In one embodiment, the body is a columnar body having a rim at a distal end thereof for engaging and sealing against a wall of the reservoir and the piston assembly further comprises a spring retained at the distal end of the columnar body for biasing the rim of the columnar body against the wall of the reservoir.
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公开(公告)号：US07655254B2
公开(公告)日：2010-02-02
申请号：US11347601
申请日：2006-02-03
申请人： Paula Dennis , Michael A. Desjardin , Stan Lam , Kui Liu , James E. Matsuura , Latha Narayanan , Catherine M. Rohloff , Pauline C. Zamora
发明人： Paula Dennis , Michael A. Desjardin , Stan Lam , Kui Liu , James E. Matsuura , Latha Narayanan , Catherine M. Rohloff , Pauline C. Zamora
CPC分类号： A61K38/21 , A61F2250/0068 , A61K9/0004 , A61K9/0019 , A61K9/0024 , A61K9/10 , A61K9/1617 , A61K9/1623 , A61K9/1694 , A61K9/19
摘要： An implantable device includes a reservoir containing a suspension of an interferon in an amount sufficient to provide continuous delivery of the interferon at a therapeutically effective rate of 1 ng/day to 600 μg/day to maintain and achieve therapeutic blood or plasma levels of the interferon throughout a substantial period of the administration period.
摘要翻译： 可植入装置包括含有干扰素悬浮液的储存器，其量足以提供以1ng /天至600ug /天的治疗有效速率连续递送干扰素，以维持和实现干扰素的治疗血浆或血浆水平 在行政期间的相当长的一段时期。
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公开(公告)号：US20100297209A1
公开(公告)日：2010-11-25
申请号：US12827265
申请日：2010-06-30
申请人： Catherine M. ROHLOFF , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
发明人： Catherine M. ROHLOFF , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
CPC分类号： A61K38/21 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K38/043 , A61K38/085 , A61K38/09 , A61K38/095 , A61K38/105 , A61K38/1808 , A61K38/185 , A61K38/191 , A61K38/2242 , A61K38/225 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/35 , A61K38/36 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , Y10T29/494 , Y10T29/49826
摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
摘要翻译： 能够悬浮活性剂的非水性单相载体。 非水性单相载体包含至少一种溶剂和至少一种聚合物，并配制成在与水性环境接触时显示相分离。 所述至少一种溶剂可以选自苯甲酸苄酯，癸醇，乳酸乙基己酯及其混合物，并且所述至少一种聚合物可以选自聚酯，吡咯烷酮，不饱和醇的酯， 不饱和醇的醚，聚氧乙烯聚氧丙烯嵌段共聚物及其混合物。 在一个实施方案中，所述至少一种溶剂是苯甲酸苄酯，并且所述至少一种聚合物是聚乙烯吡咯烷酮。 还公开了包含非水单相载体和活性剂的稳定的非水悬浮液制剂及其形成方法。
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公开(公告)号：US08206745B2
公开(公告)日：2012-06-26
申请号：US13158137
申请日：2011-06-10
申请人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
发明人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
CPC分类号： A61K38/21 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K38/043 , A61K38/085 , A61K38/09 , A61K38/105 , A61K38/11 , A61K38/1808 , A61K38/185 , A61K38/191 , A61K38/2242 , A61K38/225 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/35 , A61K38/36 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , Y10T29/494 , Y10T29/49826
摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
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公开(公告)号：US20110264077A1
公开(公告)日：2011-10-27
申请号：US13158137
申请日：2011-06-10
申请人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
发明人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
CPC分类号： A61K38/21 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K38/043 , A61K38/085 , A61K38/09 , A61K38/105 , A61K38/11 , A61K38/1808 , A61K38/185 , A61K38/191 , A61K38/2242 , A61K38/225 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/35 , A61K38/36 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , Y10T29/494 , Y10T29/49826
摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
摘要翻译： 能够悬浮活性剂的非水性单相载体。 非水性单相载体包含至少一种溶剂和至少一种聚合物，并配制成在与水性环境接触时显示相分离。 所述至少一种溶剂可以选自苯甲酸苄酯，癸醇，乳酸乙基己酯及其混合物，并且所述至少一种聚合物可以选自聚酯，吡咯烷酮，不饱和醇的酯， 不饱和醇的醚，聚氧乙烯聚氧丙烯嵌段共聚物及其混合物。 在一个实施方案中，所述至少一种溶剂是苯甲酸苄酯，并且所述至少一种聚合物是聚乙烯吡咯烷酮。 还公开了包含非水单相载体和活性剂的稳定的非水悬浮液制剂及其形成方法。
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公开(公告)号：US08460694B2
公开(公告)日：2013-06-11
申请号：US13647228
申请日：2012-10-08
申请人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
发明人： Catherine M. Rohloff , Guohua Chen , Andrew S. Luk , Rupal A. Ayer , Paul R. Houston , Michael A. Desjardin , Pauline Zamora , Stan Lam
CPC分类号： A61K38/21 , A61K9/0004 , A61K9/0024 , A61K9/10 , A61K38/043 , A61K38/085 , A61K38/09 , A61K38/105 , A61K38/11 , A61K38/1808 , A61K38/185 , A61K38/191 , A61K38/2242 , A61K38/225 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/31 , A61K38/35 , A61K38/36 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/26 , A61K47/32 , Y10T29/494 , Y10T29/49826
摘要： A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.
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