公开(公告)号：US08301242B2

公开(公告)日：2012-10-30

申请号：US13372039

申请日：2012-02-13

申请人： Michael J. Root ,  Nick A. Youker ,  Keith R. Maile

发明人： Michael J. Root ,  Nick A. Youker ,  Keith R. Maile

IPC分类号： A61N1/00

CPC分类号： A61N1/3787 ,  A61B5/02 ,  A61B2562/0217 ,  A61N1/3752 ,  A61N1/378 ,  H01M2/1055 ,  H01M6/08 ,  H01M10/0422 ,  H01M10/0436 ,  H05K13/00 ,  Y10T29/49108 ,  Y10T29/4911

摘要： One example includes a battery that includes a stack of at least one substantially planar anode and at least one substantially planar cathode, wherein the stack defines a contoured exterior, and a battery housing enclosing the stack, the battery housing defining a battery housing exterior, wherein the contoured exterior of the stack is shaped to conform to a contoured interior of the battery housing that approximately conforms to the battery housing exterior, the battery produced by the process of modeling, using fluid dynamics, an exterior of a biocompatible housing and shaping the battery housing to conform to at least some of the exterior of the biocompatible housing.

公开(公告)号：US20110082509A1

公开(公告)日：2011-04-07

申请号：US12966444

申请日：2010-12-13

申请人： Michael J. Root ,  Nick A. Youker ,  Keith R. Maile

发明人： Michael J. Root ,  Nick A. Youker ,  Keith R. Maile

IPC分类号： A61N1/00 ,  H01M2/02

CPC分类号： A61N1/3787 ,  A61B5/02 ,  A61B2562/0217 ,  A61N1/3752 ,  A61N1/378 ,  H01M2/1055 ,  H01M6/08 ,  H01M10/0422 ,  H01M10/0436 ,  H05K13/00 ,  Y10T29/49108 ,  Y10T29/4911

摘要： One example includes a battery that includes a stack of at least one substantially planar anode and at least one substantially planar cathode, wherein the stack defines a contoured exterior, and a battery housing enclosing the stack, the battery housing defining a battery housing exterior, wherein the contoured exterior of the stack is shaped to conform to a contoured interior of the battery housing that approximately conforms to the battery housing exterior, the battery produced by the process of modeling, using fluid dynamics, an exterior of a biocompatible housing and shaping the battery housing to conform to at least some of the exterior of the biocompatible housing.

摘要翻译： 一个示例包括电池，其包括至少一个基本上平面的阳极和至少一个基本上平面的阴极的堆叠，其中堆叠限定轮廓外部，以及包围堆叠的电池壳体，电池壳体限定电池壳体外部，其中 堆叠的轮廓外形被成形为符合电池壳体的轮廓内部，其大致符合电池壳体外部，通过使用流体动力学，生物相容性壳体的外部和塑造电池的建模过程产生的电池 壳体以符合生物相容性壳体的至少一些外部。

公开(公告)号：US07860564B2

公开(公告)日：2010-12-28

申请号：US11611635

申请日：2006-12-15

申请人： Michael J. Root ,  Nick A. Youker ,  Keith R. Maile

发明人： Michael J. Root ,  Nick A. Youker ,  Keith R. Maile

IPC分类号： A61N1/00

CPC分类号： A61N1/3787 ,  A61B5/02 ,  A61B2562/0217 ,  A61N1/3752 ,  A61N1/378 ,  H01M2/1055 ,  H01M6/08 ,  H01M10/0422 ,  H01M10/0436 ,  H05K13/00 ,  Y10T29/49108 ,  Y10T29/4911

摘要： One embodiment of the present subject matter includes an apparatus including a non-thin-film battery, the apparatus including a cylindrical implantable housing, electronics disposed in the implantable housing, and a battery disposed in the implantable housing, the battery comprising: a stack including at least one substantially planar anode having a thickness greater than 1 micrometer and at least one substantially planar cathode having a thickness greater than 1 micrometer, a housing enclosing the stack of substantially planar anodes and cathodes, and terminals interconnecting the battery and the electronics, wherein the battery has a volume of less than 0.024 cubic centimeters. The present subject matter includes an implantable medical device having a bobbin battery.

摘要翻译： 本主题的一个实施例包括一种包括非薄膜电池的装置，该装置包括圆柱形可植入壳体，设置在可植入壳体中的电子设备和设置在可植入壳体中的电池，该电池包括：包括： 至少一个具有大于1微米厚度的基本上平面的阳极和至少一个具有大于1微米厚度的基本上平面的阴极，包围基本上平面的阳极和阴极的堆叠的壳体以及将电池和电子装置相互连接的端子，其中 电池的体积小于0.024立方厘米。 本主题包括具有线轴电池的可植入医疗装置。

公开(公告)号：US20100029568A1

公开(公告)日：2010-02-04

申请号：US12531116

申请日：2008-03-12

申请人： Kristen Kahle ,  Suparna Paul ,  H. Kirby Steger ,  Michael J. Root

发明人： Kristen Kahle ,  Suparna Paul ,  H. Kirby Steger ,  Michael J. Root

IPC分类号： A61K38/16 ,  C07H21/04 ,  A61P31/18

CPC分类号： C07K14/005 ,  C12N2740/16122

摘要： The invention provides compositions and methods for the treatment of HIV infection, inhibition against drug-resistant strains of HIV-1 and methods of enhancing the anti-HIV potency of peptide inhibitors against drug-resistant strains of HIV-1. In particular, oligomeric C-peptide inhibitors for inhibiting HIV entry into host cells are disclosed.

摘要翻译： 本发明提供了用于治疗HIV感染，对HIV-1耐药菌株的抑制的组合物和方法以及增强针对HIV-1耐药菌株的肽抑制剂的抗HIV效力的方法。 具体地，公开了用于抑制HIV进入宿主细胞的低聚C肽抑制剂。