公开(公告)号：US20100029568A1

公开(公告)日：2010-02-04

申请号：US12531116

申请日：2008-03-12

申请人： Kristen Kahle ,  Suparna Paul ,  H. Kirby Steger ,  Michael J. Root

发明人： Kristen Kahle ,  Suparna Paul ,  H. Kirby Steger ,  Michael J. Root

IPC分类号： A61K38/16 ,  C07H21/04 ,  A61P31/18

CPC分类号： C07K14/005 ,  C12N2740/16122

摘要： The invention provides compositions and methods for the treatment of HIV infection, inhibition against drug-resistant strains of HIV-1 and methods of enhancing the anti-HIV potency of peptide inhibitors against drug-resistant strains of HIV-1. In particular, oligomeric C-peptide inhibitors for inhibiting HIV entry into host cells are disclosed.

摘要翻译： 本发明提供了用于治疗HIV感染，对HIV-1耐药菌株的抑制的组合物和方法以及增强针对HIV-1耐药菌株的肽抑制剂的抗HIV效力的方法。 具体地，公开了用于抑制HIV进入宿主细胞的低聚C肽抑制剂。

公开(公告)号：US09219293B2

公开(公告)日：2015-12-22

申请号：US12782548

申请日：2010-05-18

申请人： Ignacio Chi ,  Michael J. Root

发明人： Ignacio Chi ,  Michael J. Root

IPC分类号： H02J7/00 ,  H01M10/44 ,  H01M10/48 ,  H01M10/52

CPC分类号： H01M10/44 ,  H01M10/448 ,  H01M10/48 ,  H01M10/52 ,  H02J7/0075

摘要： The present subject matter provides apparatus and methods for controlling lithium deposition during manufacture of implantable medical device batteries. A method includes processing materials to form the battery and performing a discharge conditioning process step. The discharge conditioning process step includes using a reduced discharge load and applying a discharge load intermittently to decrease formation of lithium deposits on negatively charged surfaces within the battery.

摘要翻译： 本主题提供了在可植入医疗器械电池的制造期间控制锂沉积的装置和方法。 一种方法包括处理材料以形成电池并执行放电调节处理步骤。 放电调节处理步骤包括使用减小的放电负荷并间歇地施加放电负载以减少电池内带负电的表面上的锂沉积物的形成。

公开(公告)号：US08761877B2

公开(公告)日：2014-06-24

申请号：US12572191

申请日：2009-10-01

申请人： Ljiljana Liliana Atanasoska ,  Michael J. Root

发明人： Ljiljana Liliana Atanasoska ,  Michael J. Root

IPC分类号： A61N1/00

CPC分类号： A61N1/378 ,  H01M2/0202 ,  H01M2/026 ,  H01M2/028 ,  H01M2/1653 ,  H01M4/36 ,  H01M4/38 ,  H01M4/50 ,  H01M4/52 ,  H01M4/5825 ,  H01M4/602 ,  H01M6/34 ,  H01M2220/00 ,  Y10T29/49108

摘要： Embodiments of the invention are related to biosorbable batteries, amongst other things. In an embodiment, the invention includes a biosorbable battery assembly including an anode, a cathode, and a biosorbable separation element. The anode can include an anode material, wherein electrochemical oxidation of the anode material results in the formation of reaction products that are substantially non-toxic. The cathode can include a cathode material, wherein electrochemical reduction of the cathode material results in the formation of reaction products that are substantially non-toxic, the cathode material having a larger standard reduction potential than the material of the anode. The biosorbable separation element can be disposed between the anode and the cathode and can be configured to provide electrical insulation between the anode and the cathode. In an embodiment, the invention includes a medical device system including an implanted medical device and a biosorbable battery in electrical communication with the implanted medical device. Other embodiments are also included herein.

摘要翻译： 除其他之外，本发明的实施例涉及生物可吸收电池。 在一个实施例中，本发明包括一种包括阳极，阴极和生物可吸收分离元件的生物可吸收电池组件。 阳极可以包括阳极材料，其中阳极材料的电化学氧化导致基本上无毒的反应产物的形成。 阴极可以包括阴极材料，其中阴极材料的电化学还原导致形成基本无毒的反应产物，阴极材料具有比阳极材料更大的标准还原电位。 生物可吸收分离元件可以设置在阳极和阴极之间，并且可以被配置为在阳极和阴极之间提供电绝缘。 在一个实施例中，本发明包括医疗装置系统，其包括与植入的医疗装置电通信的植入医疗装置和生物可吸收电池。 本文还包括其它实施例。

公开(公告)号：US08311627B2

公开(公告)日：2012-11-13

申请号：US12966444

申请日：2010-12-13

申请人： Michael J. Root ,  Nick A. Youker ,  Keith R. Maile

发明人： Michael J. Root ,  Nick A. Youker ,  Keith R. Maile

IPC分类号： A61N1/00

CPC分类号： A61N1/3787 ,  A61B5/02 ,  A61B2562/0217 ,  A61N1/3752 ,  A61N1/378 ,  H01M2/1055 ,  H01M6/08 ,  H01M10/0422 ,  H01M10/0436 ,  H05K13/00 ,  Y10T29/49108 ,  Y10T29/4911

摘要： One example includes a battery that includes a stack of at least one substantially planar anode and at least one substantially planar cathode, wherein the stack defines a contoured exterior, and a battery housing enclosing the stack, the battery housing defining a battery housing exterior, wherein the contoured exterior of the stack is shaped to conform to a contoured interior of the battery housing that approximately conforms to the battery housing exterior, the battery produced by the process of modeling, using fluid dynamics, an exterior of a biocompatible housing and shaping the battery housing to conform to at least some of the exterior of the biocompatible housing.

摘要翻译： 一个示例包括电池，其包括至少一个基本上平面的阳极和至少一个基本上平面的阴极的堆叠，其中堆叠限定轮廓外部，以及包围堆叠的电池壳体，电池壳体限定电池壳体外部，其中 堆叠的轮廓外形被成形为符合电池壳体的轮廓内部，其大致符合电池壳体外部，通过使用流体动力学，生物相容性壳体的外部和塑造电池的建模过程产生的电池 壳体以符合生物相容性壳体的至少一些外部。

公开(公告)号：US07744887B2

公开(公告)日：2010-06-29

申请号：US11628164

申请日：2005-05-31

申请人： John W. Shiver ,  Michael D. Miller ,  Romas Geleziunas ,  Daria J. Hazuda ,  Peter S. Kim ,  Debra M. Eckert ,  Michael J. Root ,  Simon N. Lennard ,  Elisabetta Bianchi

发明人： John W. Shiver ,  Michael D. Miller ,  Romas Geleziunas ,  Daria J. Hazuda ,  Peter S. Kim ,  Debra M. Eckert ,  Michael J. Root ,  Simon N. Lennard ,  Elisabetta Bianchi

IPC分类号： A61K39/42 ,  G01N33/53 ,  A61K39/395 ,  C12P16/00

CPC分类号： G01N33/56988 ,  C07K16/1063 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/76 ,  G01N2500/00

摘要： Human scFvs are disclosed which interact with a conformational epitope along the pre-hairpin, N-helix coiled coil structure within the heptad repeat 1 (HR1) region of gp41 of HIV. These antibodies, as well as IgG conversions, are shown to neutralize diverse HIV isolates. Isolated nucleic acid molecules are also disclosed which encode relevant portions of these antibodies, as well as the purified forms of the expressed antibodies or relevant antibody fragments, such as VH and VL chains. The antibody compositions disclosed within this specification may provide for a therapeutic treatment against HIV infection by reducing viral load levels within an infected individual, thus prolonging the asymptomatic phase of HIV infection. These antibodies will also be useful in assays to identify HIV antiviral compounds as well as allowing for the identification of candidate HIV vaccines, such as HIV peptide vaccines.

摘要翻译： 披露了人scFv，其与艾滋病病毒gp41的七重复重复1（HR1）区域内的前发夹，N-螺旋卷曲螺旋结构与构象表位相互作用。 显示出这些抗体以及IgG转化中和多种HIV分离物。 还公开了分离的核酸分子，其编码这些抗体的相关部分，以及所表达的抗体或相关抗体片段（例如VH和VL链）的纯化形式。 在本说明书中公开的抗体组合物可通过降低受感染个体内的病毒载量水平来提供抗HIV感染的治疗性治疗，从而延长HIV感染的无症状期。 这些抗体也可用于鉴定HIV抗病毒化合物的测定，以及允许鉴定候选的HIV疫苗，例如HIV肽疫苗。

公开(公告)号：US07053179B2

公开(公告)日：2006-05-30

申请号：US09738945

申请日：2000-12-15

申请人： Michael J. Root ,  Michael S. Kay ,  David C. Chan ,  Peter S. Kim

发明人： Michael J. Root ,  Michael S. Kay ,  David C. Chan ,  Peter S. Kim

IPC分类号： C07K14/00 ,  C07K14/005 ,  C07K14/16 ,  C12Q1/70

CPC分类号： C07K14/005 ,  A61K38/162 ,  A61K39/00 ,  C07K2319/00 ,  C12N2740/16122

摘要： Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino acid residue linkers, is disclosed. Six-Helix protein, which includes the three N-helices and the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, is also disclosed.

公开(公告)号：US08873220B2

公开(公告)日：2014-10-28

申请号：US12968571

申请日：2010-12-15

申请人： Gregory J. Sherwood ,  Michael J. Root ,  Jay E. Daley ,  Eric Stemen

发明人： Gregory J. Sherwood ,  Michael J. Root ,  Jay E. Daley ,  Eric Stemen

IPC分类号： H01G9/00 ,  H01G5/38 ,  H01G9/008 ,  H01G9/012 ,  H01G9/14 ,  H01G9/08 ,  A61N1/375 ,  A61N1/378

CPC分类号： H01G9/052 ,  A61N1/375 ,  A61N1/3756 ,  A61N1/378 ,  A61N1/3782 ,  H01G9/008 ,  H01G9/012 ,  H01G9/02 ,  H01G9/08 ,  H01G9/14 ,  H01G9/15

摘要： This document provides an apparatus including a sintered electrode, a second electrode and a separator material arranged in a capacitive stack. A conductive interconnect couples the sintered electrode and the second electrode. Embodiments include a clip interconnect. In some embodiments, the interconnect includes a comb-shaped connector. In some embodiments, the interconnect includes a wire snaked between adjacent sintered substrates.

摘要翻译： 该文献提供了一种装置，其包括布置在电容堆叠中的烧结电极，第二电极和隔板材料。 导电互连将烧结电极和第二电极耦合。 实施例包括夹子互连。 在一些实施例中，互连包括梳状连接器。 在一些实施例中，互连包括在相邻烧结基片之间缠绕的线。

公开(公告)号：US20130073004A1

公开(公告)日：2013-03-21

申请号：US13674860

申请日：2012-11-12

申请人： Michael J. Root ,  Nick A. Youker ,  Keith R. Maile

发明人： Michael J. Root ,  Nick A. Youker ,  Keith R. Maile

IPC分类号： A61N1/378 ,  H05K13/00

CPC分类号： A61N1/3787 ,  A61B5/02 ,  A61B2562/0217 ,  A61N1/3752 ,  A61N1/378 ,  H01M2/1055 ,  H01M6/08 ,  H01M10/0422 ,  H01M10/0436 ,  H05K13/00 ,  Y10T29/49108 ,  Y10T29/4911

摘要： One example includes a battery that includes a stack of at least one substantially planar anode and at least one substantially planar cathode, wherein the stack defines a contoured exterior, and a battery housing enclosing the stack, the battery housing defining a battery housing exterior, wherein the contoured exterior of the stack is shaped to conform to a contoured interior of the battery housing that approximately conforms to the battery housing exterior, the battery produced by the process of modeling, using fluid dynamics, an exterior of a biocompatible housing and shaping the battery housing to conform to at least some of the exterior of the biocompatible housing.

摘要翻译： 一个示例包括电池，其包括至少一个基本上平面的阳极和至少一个基本上平面的阴极的堆叠，其中堆叠限定轮廓外部，以及包围堆叠的电池壳体，电池壳体限定电池壳体外部，其中 堆叠的轮廓外形被成形为符合电池壳体的轮廓内部，其大致符合电池壳体外部，通过使用流体动力学，生物相容性壳体的外部和塑造电池的建模过程产生的电池 壳体以符合生物相容性壳体的至少一些外部。

公开(公告)号：US20110230924A1

公开(公告)日：2011-09-22

申请号：US13038987

申请日：2011-03-02

申请人： Gregory J. Sherwood ,  Michael J. Root ,  Mary M. Byron

发明人： Gregory J. Sherwood ,  Michael J. Root ,  Mary M. Byron

IPC分类号： A61N1/05 ,  H01G4/06

CPC分类号： H01G9/07 ,  A61N1/375 ,  A61N1/3782 ,  H01G9/0032 ,  H01G9/035 ,  H01G9/145 ,  Y10T29/435

摘要： This disclosure relates to methods and apparatus for enhanced dielectric properties for electrolytic capacitors to store energy in an implantable medical device. One aspect of the present subject matter includes a method for manufacturing a capacitor adapted to be disposed in an implantable device housing. An embodiment of the method includes providing a dielectric comprising aluminum oxide and doping the aluminum oxide with an oxide having a dielectric constant greater than aluminum oxide. Doping the aluminum oxide includes using sol-gel based chemistry, electrodeposition or atomic layer deposition (ALD) in various embodiments.

摘要翻译： 本公开涉及用于在可植入医疗装置中储存能量的电解电容器的增强介电特性的方法和装置。 本主题的一个方面包括一种用于制造适于设置在可植入装置壳体中的电容器的方法。 该方法的一个实施方案包括提供包含氧化铝的电介质，并用氧化铝掺杂氧化铝和介电常数大于氧化铝的氧化物。 掺杂氧化铝包括在各种实施方案中使用基于溶胶 - 凝胶的化学，电沉积或原子层沉积（ALD）。

公开(公告)号：US07985500B2

公开(公告)日：2011-07-26

申请号：US11611649

申请日：2006-12-15

申请人： Michael J. Root ,  Nick A. Youker

发明人： Michael J. Root ,  Nick A. Youker

IPC分类号： H01M6/46 ,  A61N5/06

CPC分类号： H01M2/0277 ,  A61N1/378 ,  H01M2/0275 ,  H01M2/1022 ,  H01M2/105 ,  H01M2/204 ,  H01M10/052 ,  H01M10/0565 ,  H01M10/425

摘要： One embodiment of the present subject matter includes an apparatus for storing energy, the apparatus having a first portion comprising a flexible substrate containing a polymer electrolyte and a second portion adapted to provide a conformable housing surrounding the first portion; wherein the apparatus is adapted to provide a source of energy to an implantable device. The apparatus defines a flexible implantable device capable of traversing the circulatory system of a body with minimal obstruction of flow within the circulatory system. Further provided is a method of implanting an power source within the circulatory system of a subject's body.

摘要翻译： 本主题的一个实施例包括用于存储能量的装置，该装置具有第一部分，该第一部分包括含有聚合物电解质的柔性基底和适于提供围绕第一部分的适形外壳的第二部分; 其中所述装置适于向可植入装置提供能量源。 该装置定义了能够以最小的循环系统内的流动障碍物穿过身体的循环系统的柔性可植入装置。 还提供了在受试者的身体的循环系统内植入动力源的方法。