公开(公告)号：US5210227A

公开(公告)日：1993-05-11

申请号：US661802

申请日：1991-02-27

申请人： Hirokazu Tanaka ,  Martin E. Cooper ,  David K. Donald

发明人： Hirokazu Tanaka ,  Martin E. Cooper ,  David K. Donald

IPC分类号： A61K31/16 ,  A61K31/165 ,  A61K31/19 ,  A61K31/215 ,  A61K31/23 ,  A61P37/06 ,  C07C59/62 ,  C07C59/90 ,  C07C69/734 ,  C07C69/738 ,  C07C233/10 ,  C07C235/30 ,  C07C235/78 ,  C07D309/30 ,  C07D498/18

CPC分类号： C07D309/30 ,  C07C235/30 ,  C07C403/20 ,  C07C69/734 ,  C07C69/738 ,  C07C2101/14

摘要： Compounds of formula I, ##STR1## wherein R.sup.1 represents H, OH, protected OH or alkoxy; R.sup.2 represents H; R.sup.3 represents O or (H,OH); R.sup.4 represents methyl, ethyl, propyl or allyl; R.sup.5 represents OH, protected OH or alkoxy; R.sup.6 represents OH; R.sup.7 represents OH, alkoxy or NR.sup.8 R.sup.9 where R.sup.8 and R.sup.9 independently represent H, alkyl or aryl; in addition, R.sup.1 and R.sup.2 may together represent a second bond between the carbon atoms to which they are attached; and R.sup.6 and R.sup.7 may together represent O; and pharmaceutically acceptable salts thereof; are useful inter alia as immunosuppressive agents. The invention also provides the novel compounds of formula I.

公开(公告)号：US4599361A

公开(公告)日：1986-07-08

申请号：US774491

申请日：1985-09-10

申请人： Jonathan P. Dickens ,  David K. Donald ,  Geoffrey Kneen ,  William R. McKay

发明人： Jonathan P. Dickens ,  David K. Donald ,  Geoffrey Kneen ,  William R. McKay

IPC分类号： A61K38/43 ,  C07C233/02 ,  C07C237/00 ,  C07C83/10 ,  A61K31/085 ,  A61K31/165 ,  A61K31/185

CPC分类号： C07C233/02 ,  C07C237/00

摘要： This disclosure relates to a novel class of hydroxamic acid based collagenase inhibitor derivatives. The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions in the treatment of collagenase induced diseases.

摘要翻译： 本公开涉及一类新型异羟肟酸胶原酶抑制剂衍生物。 本公开还涉及含有这些化合物的药物组合物以及这些化合物和组合物在治疗胶原酶诱导的疾病中的用途。