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公开(公告)号:US4743587A
公开(公告)日:1988-05-10
申请号:US880130
申请日:1986-07-07
IPC分类号: C12N9/99 , A61K31/16 , A61K31/165 , A61K38/43 , A61P29/00 , A61P43/00 , C07C233/02 , C07C237/00 , C07C237/06 , C07C237/20 , C07C237/22 , C07C259/06 , C07C83/10 , A61K31/085 , A61K31/185
CPC分类号: C07C233/02 , C07C237/00
摘要: Thid disclosure relates to a novel class of hydroxamic acid based collagenase inhibitor derivatives. The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions in the treatment of collagenase induced diseases.
摘要翻译: 公开涉及一类新型异羟肟酸胶原酶抑制剂衍生物。 本公开还涉及含有这些化合物的药物组合物以及这些化合物和组合物在治疗胶原酶诱导的疾病中的用途。
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公开(公告)号:US4628104A
公开(公告)日:1986-12-09
申请号:US720917
申请日:1985-04-08
IPC分类号: C07D233/54 , C07D249/08 , C07D521/00 , C07D233/66 , C07D401/00
CPC分类号: C07D231/12 , C07D233/56 , C07D249/08
摘要: This disclosure relates to a class of novel compounds of the formula: ##STR1## wherein R.sup.1 is C.sub.1 -C.sub.4 alkyl, phenyl or C.sub.1 -C.sub.4 alkylphenyl;R.sup.2 is C.sub.1 -C.sub.7 alkyl, benzyl, pyridyl, phenyl, halophenyl or dihalophenyl; andA is imidazol-1-yl, 1,2,4-triazol-1-yl or substituted imidazol-1-yl wherein the substituent is one or more groups selected from class consisting of C.sub.1 -C.sub.4 alkylthio and carboxy(C.sub.2 -C.sub.4 alkenyl);and pharmaceutically acceptable acid addition salts thereof. This invention further relates to pharmaceutical compositions containing the compounds and to the use of such compounds and compositions as anti-anaerobic agents.
摘要翻译: 本公开涉及一类新的下式化合物:其中R 1是C 1 -C 4烷基,苯基或C 1 -C 4烷基苯基; R2是C1-C7烷基,苄基,吡啶基,苯基,卤代苯基或二卤代苯基; 和A是咪唑-1-基,1,2,4-三唑-1-基或取代的咪唑-1-基,其中取代基是一个或多个选自C 1 -C 4烷硫基和羧基(C 2 -C 4) 烯基); 及其药学上可接受的酸加成盐。 本发明还涉及含有这些化合物的药物组合物以及这种化合物和组合物作为抗厌氧剂的用途。
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公开(公告)号:US4599361A
公开(公告)日:1986-07-08
申请号:US774491
申请日:1985-09-10
IPC分类号: A61K38/43 , C07C233/02 , C07C237/00 , C07C83/10 , A61K31/085 , A61K31/165 , A61K31/185
CPC分类号: C07C233/02 , C07C237/00
摘要: This disclosure relates to a novel class of hydroxamic acid based collagenase inhibitor derivatives. The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions in the treatment of collagenase induced diseases.
摘要翻译: 本公开涉及一类新型异羟肟酸胶原酶抑制剂衍生物。 本公开还涉及含有这些化合物的药物组合物以及这些化合物和组合物在治疗胶原酶诱导的疾病中的用途。
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公开(公告)号:US4442896A
公开(公告)日:1984-04-17
申请号:US400323
申请日:1982-07-21
申请人: Lucio V. Reale , William R. McKay
发明人: Lucio V. Reale , William R. McKay
IPC分类号: E21B4/02 , E21B7/04 , E21B29/00 , E21B43/00 , E21B43/04 , E21B43/16 , E21B43/247 , E21B43/26 , E21B43/30 , E21C25/54
CPC分类号: E21B43/295 , E21B29/00 , E21B43/04 , E21B43/247 , E21B43/26 , E21B43/305 , E21C41/31
摘要: A method of preparing an underground bed for treatment. A channel is formed in the bed extending from the ground down through the bed and up to the ground. A cutting device is inserted into the channel operated to form a pathway in a substantially vertical plane.
摘要翻译: 一种地下床处理方法。 在床上形成一个通道,从地面向下延伸穿过床,直到地面。 将切割装置插入通道中,以在基本垂直的平面中形成路径。
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公开(公告)号:US4403154A
公开(公告)日:1983-09-06
申请号:US331734
申请日:1981-12-17
申请人: Lucio V. Reale , William R. McKay
发明人: Lucio V. Reale , William R. McKay
摘要: An apparatus to generate electricity. There is a first cylinder having an open end and containing a first piston. A second cylinder has an open end and contains a second piston. A pipe communicates the two cylinders at the ends remote from their open ends. A closure can be moved to close and open the open end of each cylinder in sequence. The system receives a liquid between that part of the apparatus defined by the cylinders and the pipe and between the two pistons. An electrical generator is operated by movement of the liquid in the apparatus to generate electricity when fluid pressure acts on the first piston in the first cylinder, with the second cylinder closed by the closure, it moves the first piston inwardly, moving the liquid to the second piston through the pipe. Movement of the piston and thus of the liquid acts to operate the electrical generator. Movement of the closure closes the first cylinder and opens the second cylinder. This allows the fluid pressure to act on the second piston to move the first piston back to its start position. Electricity is also generated by movement of the second piston inwardly.
摘要翻译: 发电的装置。 存在具有开口端并包含第一活塞的第一气缸。 第二气缸具有开口端并包含第二活塞。 管道在距开口端远端的两端连通两个气缸。 闭合件可以移动以依次关闭并打开每个气缸的开口端。 系统在由气缸和管道限定的设备的该部分之间以及两个活塞之间接收液体。 当液体作用在第一气缸中的第一活塞上时,发电机通过液体在设备中的运动而发电,第二气缸由闭合器封闭,使第一活塞向内移动,将液体移动到 第二活塞通过管道。 活塞和液体的移动用于操作发电机。 闭合件的运动闭合第一气缸并打开第二气缸。 这允许流体压力作用在第二活塞上以使第一活塞回到其起始位置。 电力也是通过向内移动第二活塞而产生的。
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