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44 条记录 (耗时 0.055 秒)

    IL-21 antagonists
    32.
    发明授权
    IL-21 antagonists 有权
    IL-21拮抗剂

    公开(公告)号：US07923539B2

    公开(公告)日：2011-04-12

    申请号：US12179003

    申请日：2008-07-24

    申请人： Pallavur V. Sivakumar ,  Stephen R. Jaspers

    发明人： Pallavur V. Sivakumar ,  Stephen R. Jaspers

    IPC分类号： C12P21/08 ,  A61K39/395 ,  C07K16/24

    CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/30 ,  Y10S530/809

    摘要： Monoclonal antibodies are identified that bind the IL-21 protein. These antibodies are used to identify regions of the IL-21 protein to where binding neutralizes IL-21 activity. Hybridomas and methods of producing anti-IL-21 monoclonal antibodies are described. The monoclonal antibodies are useful in treating IL-21-mediated diseases, which may include autoimmune and inflammatory diseases such as pancreatitis, type I diabetes (IDDM), Graves Disease, inflammatory bowel disease (IBD), Crohn's Disease, ulcerative colitis, irritable bowel syndrome, multiple sclerosis, rheumatoid arthritis, diverticulosis, systemic lupus erythematosus, psoriasis, ankylosing spondylitis, scleroderma, systemic sclerosis, psoriatic arthritis, osteoarthritis, atopic dermatitis, vitiligo, graft vs. host disease (GVHD), cutaneous T cell lymphoma (CTCL), Sjogren's syndrome, glomerulonephritis, IgA nephropathy, graft versous host disease, transplant rejection, atopic dermatitis, anti-phospholipid syndrome, and asthma, and other autoimmune diseases.

    摘要翻译： 鉴定结合IL-21蛋白的单克隆抗体。 这些抗体用于鉴定结合中和IL-21活性的IL-21蛋白的区域。 描述了杂交瘤和产生抗IL-21单克隆抗体的方法。 单克隆抗体可用于治疗IL-21介导的疾病，其可能包括自身免疫性和炎性疾病如胰腺炎，I型糖尿病（IDDM），格雷夫斯病，炎性肠病（IBD），克罗恩病，溃疡性结肠炎，肠易激综合征 综合征，多发性硬化症，类风湿性关节炎，憩室病，系统性红斑狼疮，牛皮癣，强直性脊柱炎，硬皮病，系统性硬化症，银屑病关节炎，骨关节炎，特应性皮炎，白癜风，移植物抗宿主病（GVHD），皮肤T细胞淋巴瘤 ，干燥综合征，肾小球性肾炎，IgA肾病，移植排斥反应，特应性皮炎，抗磷脂综合征，哮喘和其他自身免疫性疾病。

    Anti-human IL-21 antibodies
    37.
    发明授权
    Anti-human IL-21 antibodies 有权
    抗人IL-21抗体

    公开(公告)号：US09388241B2

    公开(公告)日：2016-07-12

    申请号：US13492315

    申请日：2012-06-08

    申请人： Pallavur V. Sivakumar ,  Stephen R. Jaspers

    发明人： Pallavur V. Sivakumar ,  Stephen R. Jaspers

    IPC分类号： A61K39/395 ,  C07K16/22 ,  C07K16/24 ,  C07K16/18 ,  A61K39/00

    CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2319/30 ,  Y10S530/809

    摘要： Monoclonal antibodies are identified that bind the IL-21 protein. These antibodies are used to identify regions of the IL-21 protein to where binding neutralizes IL-21 activity. Hybridomas and methods of producing anti-IL-21 monoclonal antibodies are described. The monoclonal antibodies are useful in treating IL-21-mediated diseases, which may include autoimmune and inflammatory diseases such as pancreatitis, type I diabetes (IDDM), Graves Disease, inflammatory bowel disease (IBD), Crohn's Disease, ulcerative colitis, irritable bowel syndrome, multiple sclerosis, rheumatoid arthritis, diverticulosis, systemic lupus erythematosus, psoriasis, ankylosing spondylitis, scleroderma, systemic sclerosis, psoriatic arthritis, osteoarthritis, atopic dermatitis, vitiligo, graft vs. host disease (GVHD), cutaneous T cell lymphoma (CTCL), Sjogren's syndrome, glomerulonephritis, IgA nephropathy, transplant rejection, atopic dermatitis, anti-phospholipid syndrome, and asthma, and other autoimmune diseases.

    摘要翻译： 鉴定结合IL-21蛋白的单克隆抗体。 这些抗体用于鉴定结合中和IL-21活性的IL-21蛋白的区域。 描述了杂交瘤和产生抗IL-21单克隆抗体的方法。 单克隆抗体可用于治疗IL-21介导的疾病，其可能包括自身免疫性和炎性疾病如胰腺炎，I型糖尿病（IDDM），格雷夫斯病，炎性肠病（IBD），克罗恩病，溃疡性结肠炎，肠易激综合征 综合征，多发性硬化症，类风湿性关节炎，憩室病，系统性红斑狼疮，牛皮癣，强直性脊柱炎，硬皮病，系统性硬化症，银屑病关节炎，骨关节炎，特应性皮炎，白癜风，移植物抗宿主病（GVHD），皮肤T细胞淋巴瘤 ，干燥综合征，肾小球性肾炎，IgA肾病，移植排斥反应，特应性皮炎，抗磷脂综合征，哮喘和其他自身免疫性疾病。