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    Feature point detecting device, feature point detecting method, and feature point detecting program
    31.
    发明申请
    Feature point detecting device, feature point detecting method, and feature point detecting program 有权
    特征点检测装置，特征点检测方法和特征点检测程序

    公开(公告)号：US20070217683A1

    公开(公告)日：2007-09-20

    申请号：US11717139

    申请日：2007-03-13

    申请人： Koichi Kinoshita

    发明人： Koichi Kinoshita

    IPC分类号： G06K9/46

    CPC分类号： G06K9/00214 ,  G06K9/6209

    摘要： A device and method for detecting feature points of an object from an image. A three-dimensional model is created in which a plurality of nodes corresponding to feature points in a learning image are defined. The model is projected onto an input image and a feature value is derived from a plurality of sampling points around a projection point of each node. An error estimated amount is computed based on the displacement of a feature point between a correct model and an error model. The three dimensional position of each feature point in the input image is estimated based on the error estimated amount and a three dimensional model.

    摘要翻译： 一种用于从图像中检测物体的特征点的装置和方法。 创建三维模型，其中定义了与学习图像中的特征点对应的多个节点。 将模型投影到输入图像上，并且从每个节点的投影点周围的多个采样点导出特征值。 基于正确模型和误差模型之间的特征点的位移来计算误差估计量。 基于误差估计量和三维模型估计输入图像中的每个特征点的三维位置。

    Process for preparing pharmacologically acceptable salt of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid
    36.
    发明授权
    Process for preparing pharmacologically acceptable salt of n-(1(s)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid 失效
    制备正（（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酰 - 氨基酸的药学上可接受的盐的方法

    公开(公告)号：US06518436B2

    公开(公告)日：2003-02-11

    申请号：US09989186

    申请日：2001-11-21

    申请人： Yasuyoshi Ueda ,  Koichi Kinoshita ,  Tadashi Moroshima ,  Yoshifumi Yanagida ,  Yoshihide Fuse

    发明人： Yasuyoshi Ueda ,  Koichi Kinoshita ,  Tadashi Moroshima ,  Yoshifumi Yanagida ,  Yoshihide Fuse

    IPC分类号： C07D20704

    CPC分类号： C07K5/0222 ,  C07K5/06026

    摘要： There is provided a process for preparing a pharmacologically acceptable salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid which comprises condensing an amino acid and N-(1(S) -ethoxycarbonyl-3-phenylpropyl)-L-alanine N-carboxy-anhydride under basic condition, carrying out decarboxylation under between neutral and acidic condition to obtain N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid, and forming a pharmacologically acceptable salt thereof, wherein the production of a by-product (3): is suppressed by carrying out in an aqueous liquid a series of operations till formation of the pharmacologically acceptable salt or till isolation of the pharmacologically acceptable salt. The present invention enables to prepare the pharmacologically acceptable salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-amino acid having high quality, in a commercial scale with high yield and economical efficiency.

    摘要翻译： 提供了制备N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酰 - 氨基酸的药学上可接受的盐的方法，其包括将氨基酸和N-（1（S） - 乙氧基羰基 - 3-苯基丙基）-L-丙氨酸N-羧酸酐，在中性和酸性条件下进行脱羧，得到N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酰 - 氨基酸， 并形成其药学上可接受的盐，其中通过在含水液体中进行一系列操作直至形成药理学上可接受的盐或直到药理学上可接受的盐的分离来抑制副产物（3）的产生。 本发明能够以高产率和经济效益以商业规模制备质量高的N-（1（S） - 乙氧基羰基-3-苯基丙基）-L-丙氨酰 - 氨基酸的药理学上可接受的盐。

    Simple process for producing high quality captopril
    37.
    发明授权
    Simple process for producing high quality captopril 失效
    生产高品质卡托普利的简单过程

    公开(公告)号：US06187932B1

    公开(公告)日：2001-02-13

    申请号：US09077747

    申请日：1998-08-03

    申请人： Koichi Kinoshita ,  Fumihiko Kano ,  Takahiro Okubo ,  Yasuyoshi Ueda

    发明人： Koichi Kinoshita ,  Fumihiko Kano ,  Takahiro Okubo ,  Yasuyoshi Ueda

    IPC分类号： C07D20712

    CPC分类号： C07D207/16

    摘要： A process for producing captopril of the following formula (1) comprising subjecting a substrate compound of the following general formula (2) to a hydrolysis reaction in aqueous medium to remove the RCO group and isolating the product compound, said hydrolysis reaction in aqueous medium being conducted in the presence of a strong acid at pH not over 1 and a reaction temperature not below 40° C.

    摘要翻译： 一种制备下式（1）的卡托普利的方法，包括使下列通式（2）的底物化合物在水性介质中进行水解反应以除去RCO基团并分离产物化合物，水介质中的所述水解反应为 在pH不超过1，反应温度不低于40℃的强酸存在下进行。

    Process for producing N-(D-.alpha.-methyl-.beta.-mercaptopropionyl)-L-proline and its intermediate
    38.
    发明授权
    Process for producing N-(D-.alpha.-methyl-.beta.-mercaptopropionyl)-L-proline and its intermediate 失效
    制备N-（D-α-甲基-β-巯基丙酰基）-L-脯氨酸及其中间体的方法

    公开(公告)号：US5917055A

    公开(公告)日：1999-06-29

    申请号：US849337

    申请日：1997-07-31

    申请人： Yasuyoshi Ueda ,  Fumihiko Kanou ,  Koichi Kinoshita ,  Takahiro Okubo

    发明人： Yasuyoshi Ueda ,  Fumihiko Kanou ,  Koichi Kinoshita ,  Takahiro Okubo

    IPC分类号： A61K31/00 ,  C07D207/16

    CPC分类号： C07D207/16

    摘要： A highly convenient and efficient process for economically producing in a high yield high-quality captopril which is remarkably reduced in the content of impurities and has a high melting point and intermediates for synthesizing the same which contain only a small amount of precursors as impurities and have excellent qualities. The process comprises subjecting an acid halide and an L-proline to the Schotten-Baumann reaction and eliminating the impurities formed as the by-products in the form of the precursors represented by general formula (5) or (6) by treating, during or after the Schotten-Baumann reaction, the aqueous medium solution with active carbon or crystallization followed by deacylation. In the formula, R.sup.1 represents acyl and n represents an integer of from 2 to 4. ##STR1##

    摘要翻译： PCT No.PCT / JP96 / 02902 Sec。 371日期1997年7月31日 102（e）1997年7月31日PCT PCT 1996年10月7日PCT公布。 公开号WO97 / 12858 日期1997年04月10日在高产量的高品质卡托普利经济地生产方法中高度方便和高效的方法，其显着降低了杂质含量，并且具有高熔点和用于合成它们的中间体，其仅含有少量的 前体作为杂质，具有优良的品质。 该方法包括使酰卤和L-脯氨酸进行Schotten-Baumann反应，并通过在通式（5）或（6）表示的前体中处理， 在Schotten-Baumann反应之后，将含有活性炭的水介质溶液或结晶，然后脱酰基化。 式中，R1表示酰基，n表示2〜4的整数。

    Charging device for electronic copier
    40.
    发明授权
    Charging device for electronic copier 失效
    电子复印机充电装置

    公开(公告)号：US4387980A

    公开(公告)日：1983-06-14

    申请号：US218444

    申请日：1980-12-19

    申请人： Tsuyoshi Ueno ,  Hideo Mukai ,  Yoshitsugu Nakatomi ,  Hiroshi Saito ,  Koichi Kinoshita ,  Takaaki Konuma

    发明人： Tsuyoshi Ueno ,  Hideo Mukai ,  Yoshitsugu Nakatomi ,  Hiroshi Saito ,  Koichi Kinoshita ,  Takaaki Konuma

    IPC分类号： G03G15/02 ,  G03G15/00 ,  G03G15/16

    CPC分类号： G03G15/0216

    摘要： In an electronic copier provided with a light-sensitive medium, a charging station, an exposure station, a developing station, a transfer station and a fixing unit, the charging station includes a plurality of contact charging elements in contact with the light-sensitive medium and a voltage supply means for applying voltages to the contact charging elements. A voltage continuously rising in a predetermined period of time is supplied from the voltage supply means to the contact charging elements with the rotation of light-sensitive medium, and the light-sensitive medium is thus uniformly charged.

    摘要翻译： 在设置有感光介质，充电站，曝光站，显影站，转印站和定影单元的电子复印机中，充电站包括与感光介质接触的多个接触充电元件 以及用于向接触充电元件施加电压的电压供给装置。 在预定时间段内连续上升的电压随着光敏介质的旋转从电压供给装置提供给接触充电元件，因此光敏介质被均匀地充电。