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    Responsive neurostimulation for the treatment of chronic cardiac dysfunction
    34.
    发明授权
    Responsive neurostimulation for the treatment of chronic cardiac dysfunction 有权
    响应性神经刺激治疗慢性心脏功能障碍

    公开(公告)号：US09272143B2

    公开(公告)日：2016-03-01

    申请号：US14271714

    申请日：2014-05-07

    Applicant: CYBERONICS, INC. ,  East Tennessee State University

    Inventor： Imad Libbus ,  Badri Amurthur ,  Bruce H. KenKnight ,  Jeffrey L. Ardell

    IPC: A61N1/00 ,  A61N1/36

    CPC classification number: A61N1/36114 ,  A61N1/36053 ,  A61N1/36135 ,  A61N1/36139 ,  A61N1/3615 ,  A61N1/37217 ,  A61N1/37264

    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. The implanted stimulation device includes a physiological sensor for monitoring the patient's response to the neurostimulation therapy on an ambulatory basis over extended periods of time, and a control system for adjusting stimulation parameters to maintain stimulation in the neural fulcrum zone based on detected changes in the physiological response to stimulation.

    Abstract translation: 提供系统和方法用于向患者提供神经刺激疗法用于治疗慢性心力衰竭。 识别神经支点区域，并在神经支点区域内递送正在进行的神经刺激治疗。 植入刺激装置包括生理传感器，用于在延长的时间段内基于动态监视患者对神经刺激疗法的反应，以及控制系统，用于根据检测到的生理变化调整刺激参数以维持神经支点区域中的刺激 对刺激的反应。

    CUSTOMIZABLE TITRATION FOR AN IMPLANTABLE NEUROSTIMULATOR
    35.
    发明申请
    CUSTOMIZABLE TITRATION FOR AN IMPLANTABLE NEUROSTIMULATOR 有权

    公开(公告)号：US20240399153A1

    公开(公告)日：2024-12-05

    申请号：US18731997

    申请日：2024-06-03

    Applicant: LivaNova USA, Inc.

    Inventor： Scott Stubbs ,  Imad Libbus ,  Scott Mazar ,  Bruce KenKnight ,  Badri Amurthur

    IPC: A61N1/36 ,  A61N1/365 ,  A61N1/372 ,  G16H20/30 ,  G16H40/63

    Abstract: Systems and methods for customizable titration of an implantable neurostimulator are provided. A method of titrating a neurostimulation signal delivered to a patient from an implantable pulse generator includes delivering a first neurostimulation signal with a first set of parameters, increasing a first value of the first neurostimulation signal at a first rate for a first period of time while delivering the first neurostimulation signal, ceasing delivery of the first neurostimulation signal when the first value reaches a first target value, delivering a second neurostimulation signal with a second set of parameters, and increasing the second neurostimulation signal at a second rate for a second period of time while delivering the second neurostimulation signal.

    Titration assist system
    38.
    发明授权
    Titration assist system 有权

    公开(公告)号：US11633600B2

    公开(公告)日：2023-04-25

    申请号：US17136804

    申请日：2020-12-29

    Applicant: LivaNova USA, Inc.

    Inventor： Imad Libbus ,  Bruce KenKnight ,  Scott Stubbs ,  Scott Mazar

    IPC: A61N1/36

    Abstract: A neurostimulation system comprises a sensor and a control system. The sensor is configured to detect a cardiac physiological measure of a patient. The control system is programmed to monitor, via the sensor, the cardiac physiological measure during the treatment. The control system is further programmed to detect a change in the cardiac physiological measure during the treatment. The control system is further programmed to determine, based on the detected change in the cardiac physiological measure, a first transition time in a duty cycle of a neurostimulation signal delivered to the patient where the neurostimulation signal transitions between a stimulation OFF period and a stimulation ON period.

    Evaluation of vagus nerve stimulation using heart rate variability analysis
    39.
    发明授权
    Evaluation of vagus nerve stimulation using heart rate variability analysis 有权

    公开(公告)号：US11554263B2

    公开(公告)日：2023-01-17

    申请号：US16422746

    申请日：2019-05-24

    Applicant: LivaNova USA, Inc.

    Inventor： Imad Libbus ,  Bruce D. Nearing ,  Badri Amurthur ,  Bruce H. KenKnight ,  Richard L. Verrier

    IPC: A61N1/36 ,  A61B5/024 ,  A61B5/352 ,  A61B5/366

    Abstract: An implantable vagus nerve stimulation (VNS) system includes a sensor configured to measure ECG data for a patient, a stimulation subsystem configured to deliver VNS to the patient, and a control system configured to perform a heart rate variability analysis with the ECG data. In some aspects, performing the heart rate variability analysis includes measuring R-R intervals between successive R-waves for the ECG data measured during a stimulation period and a baseline period, plotting each R-R interval against an immediately preceding R-R interval for each of the stimulation period and the baseline period, and determining at least one of a standard deviation from an axis of a line perpendicular to an identity line for each of the stimulation period plot and the baseline period plot or a centroid of each of the stimulation period plot and the baseline period plot.

    TITRATION ASSIST SYSTEM
    40.
    发明申请
    TITRATION ASSIST SYSTEM 有权

    公开(公告)号：US20220203095A1

    公开(公告)日：2022-06-30

    申请号：US17136804

    申请日：2020-12-29

    Applicant: LivaNova USA, Inc.

    Inventor： Imad Libbus ,  Bruce KenKnight ,  Scott Stubbs ,  Scott Mazar

    IPC: A61N1/36

    Abstract: A neurostimulation system comprises a sensor and a control system. The sensor is configured to detect a cardiac physiological measure of a patient. The control system is programmed to monitor, via the sensor, the cardiac physiological measure during the treatment. The control system is further programmed to detect a change in the cardiac physiological measure during the treatment. The control system is further programmed to determine, based on the detected change in the cardiac physiological measure, a first transition time in a duty cycle of a neurostimulation signal delivered to the patient where the neurostimulation signal transitions between a stimulation OFF period and a stimulation ON period.

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