公开(公告)号：US20240382755A1

公开(公告)日：2024-11-21

申请号：US18663956

申请日：2024-05-14

Applicant: LivaNova USA, Inc.

Inventor： Imad Libbus ,  Bruce D. Nearing ,  Badri Amurthur ,  Bruce H. KenKnight ,  Richard L. Verrier

IPC: A61N1/36 ,  A61B5/024 ,  A61B5/352 ,  A61B5/366

Abstract: An implantable vagus nerve stimulation (VNS) system includes a sensor configured to measure ECG data for a patient, a stimulation subsystem configured to deliver VNS to the patient, and a control system configured to perform a heart rate variability analysis with the ECG data. In some aspects, performing the heart rate variability analysis includes measuring R-R intervals between successive R-waves for the ECG data measured during a stimulation period of VNS therapy and a baseline period of the VNS therapy, wherein the stimulation period comprises at least a portion of the ON period and the baseline period comprises at least a portion of the OFF period immediately preceding the ON period, and generating a plot of each R-R interval against an immediately successive R-R interval for each of the stimulation period and the baseline period configured to be displayed on a display.

公开(公告)号：US11554263B2

公开(公告)日：2023-01-17

申请号：US16422746

申请日：2019-05-24

Applicant: LivaNova USA, Inc.

Inventor： Imad Libbus ,  Bruce D. Nearing ,  Badri Amurthur ,  Bruce H. KenKnight ,  Richard L. Verrier

IPC: A61N1/36 ,  A61B5/024 ,  A61B5/352 ,  A61B5/366

Abstract: An implantable vagus nerve stimulation (VNS) system includes a sensor configured to measure ECG data for a patient, a stimulation subsystem configured to deliver VNS to the patient, and a control system configured to perform a heart rate variability analysis with the ECG data. In some aspects, performing the heart rate variability analysis includes measuring R-R intervals between successive R-waves for the ECG data measured during a stimulation period and a baseline period, plotting each R-R interval against an immediately preceding R-R interval for each of the stimulation period and the baseline period, and determining at least one of a standard deviation from an axis of a line perpendicular to an identity line for each of the stimulation period plot and the baseline period plot or a centroid of each of the stimulation period plot and the baseline period plot.

公开(公告)号：US20230146182A1

公开(公告)日：2023-05-11

申请号：US18092716

申请日：2023-01-03

Applicant: LivaNova USA, Inc.

Inventor： Imad Libbus ,  Bruce D. Nearing ,  Badri Amurthur ,  Bruce H. KenKnight ,  Richard L. Verrier

IPC: A61N1/36 ,  A61B5/024

CPC classification number: A61N1/36114 ,  A61N1/36139 ,  A61B5/02405 ,  A61N1/36196 ,  A61N1/3616 ,  A61N1/36175 ,  A61B5/352

Abstract: An implantable vagus nerve stimulation (VNS) system includes a sensor configured to measure ECG data for a patient, a stimulation subsystem configured to deliver VNS to the patient, and a control system configured to perform a heart rate variability analysis with the ECG data. In some aspects, performing the heart rate variability analysis includes measuring R-R intervals between successive R-waves for the ECG data measured during a stimulation period of VNS therapy and a baseline period of the VNS therapy, wherein the stimulation period comprises at least a portion of the ON period and the baseline period comprises at least a portion of the OFF period immediately preceding the ON period, and generating a plot of each R-R interval against an immediately successive R-R interval for each of the stimulation period and the baseline period configured to be displayed on a display.

公开(公告)号：US11980758B2

公开(公告)日：2024-05-14

申请号：US18092716

申请日：2023-01-03

Applicant: LivaNova USA, Inc.

Inventor： Imad Libbus ,  Bruce D. Nearing ,  Badri Amurthur ,  Bruce H. KenKnight ,  Richard L. Verrier

IPC: A61N1/36 ,  A61B5/024 ,  A61B5/352 ,  A61B5/366

CPC classification number: A61N1/36114 ,  A61B5/02405 ,  A61N1/36139 ,  A61B5/352 ,  A61B5/366 ,  A61N1/3616 ,  A61N1/36175 ,  A61N1/36196

Abstract: An implantable vagus nerve stimulation (VNS) system includes a sensor configured to measure ECG data for a patient, a stimulation subsystem configured to deliver VNS to the patient, and a control system configured to perform a heart rate variability analysis with the ECG data. In some aspects, performing the heart rate variability analysis includes measuring R-R intervals between successive R-waves for the ECG data measured during a stimulation period of VNS therapy and a baseline period of the VNS therapy, wherein the stimulation period comprises at least a portion of the ON period and the baseline period comprises at least a portion of the OFF period immediately preceding the ON period, and generating a plot of each R-R interval against an immediately successive R-R interval for each of the stimulation period and the baseline period configured to be displayed on a display.