公开(公告)号：US20200048720A1

公开(公告)日：2020-02-13

申请号：US16665738

申请日：2019-10-28

Applicant: Exact Sciences Development Company, LLC ,  Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  Hongzhi Zou ,  Graham P. Lidgard

IPC: C12Q1/6886 ,  C12Q1/6858 ,  C12Q1/6827

Abstract: The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.

公开(公告)号：US20190249263A1

公开(公告)日：2019-08-15

申请号：US16399467

申请日：2019-04-30

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.

公开(公告)号：US20190161806A1

公开(公告)日：2019-05-30

申请号：US16202944

申请日：2018-11-28

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Tracy C. Yab ,  John B. Kisiel ,  Hatim T. Allawi ,  Graham P. Lidgard ,  Michael W. Kaiser

IPC: C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/682

Abstract: Provided herein is technology for breast cancer screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of breast cancer.

公开(公告)号：US20180251859A1

公开(公告)日：2018-09-06

申请号：US15971561

申请日：2018-05-04

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Development Company, LLC

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Hatim T. Allawi

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/16

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as gastric cancer.

公开(公告)号：US20180066320A1

公开(公告)日：2018-03-08

申请号：US15694300

申请日：2017-09-01

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Corporation

Inventor： William R. Taylor ,  David A. Ahlquist ,  Douglas W. Mahoney ,  John B. Kisiel ,  Tracy C. Yab ,  Hatim T. Allawi ,  Maria Giakoumopoulos ,  Graham P. Lidgard

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/16 ,  C12Q2600/166

Abstract: Provided herein is technology for hepatocellular carcinoma screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of hepatocellular carcinoma.

公开(公告)号：US20170298439A1

公开(公告)日：2017-10-19

申请号：US15487124

申请日：2017-04-13

Applicant: Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney

IPC: C12Q1/68 ,  G06F19/00

CPC classification number: C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/16 ,  G16H50/20

Abstract: Provided herein is technology for colorectal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of colorectal neoplasia in 1) individuals at, older or younger than 50 years of age, or 2) individuals having Lynch Syndrome.

公开(公告)号：US20170073772A1

公开(公告)日：2017-03-16

申请号：US15301227

申请日：2015-03-26

Applicant: Mayo Foundation for Medical Education and Research ,  Exact Sciences Corporation

Inventor： David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Graham P. Lidgard ,  Hatim T. Allawi

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.

Abstract translation: 本文提供了涉及检测瘤形成的技术，特别是但不排他地涉及用于检测恶化前和恶性肿瘤如结肠直肠癌的方法，组合物和相关用途。

公开(公告)号：US20160251727A1

公开(公告)日：2016-09-01

申请号：US15054860

申请日：2016-02-26

Applicant: Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Douglas W. Mahoney ,  Tracy C. Yab

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154

Abstract: Provided herein is technology for gastrointestinal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of gastrointestinal neoplasm, and classifying the site location of such a gastrointestinal neoplasm (e.g., a colorectal region, a pancreaticobiliary region, a gastroesophageal region).

Abstract translation: 本文提供了用于胃肠道肿瘤筛选的技术，特别但并非排他地涉及用于检测胃肠道肿瘤存在的方法，组合物和相关用途，以及对这种胃肠道肿瘤（例如，结肠直肠区域，胰胆管炎 区域，胃食管区域）。

公开(公告)号：US20250137068A1

公开(公告)日：2025-05-01

申请号：US18955252

申请日：2024-11-21

Applicant: Mayo Foundation for Medical Education and Research

Inventor： John B. Kisiel ,  David A. Ahlquist ,  William R. Taylor ,  Douglas W. Mahoney ,  Tracy C. Yab

IPC: C12Q1/6886

Abstract: Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting neoplasms such as cholangiocarcinoma.

公开(公告)号：US20240368702A1

公开(公告)日：2024-11-07

申请号：US18628011

申请日：2024-04-05

Applicant: Exact Sciences Corporation ,  Mayo Foundation for Medical Education and Research

Inventor： David A. Ahlquist ,  William R. Taylor ,  Hongzhi Zou ,  Graham P. Lidgard

IPC: C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6858

Abstract: The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.