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公开(公告)号:US20100304623A1
公开(公告)日:2010-12-02
申请号:US12787602
申请日:2010-05-26
申请人: Daniel Poon , Kyle Smith
发明人: Daniel Poon , Kyle Smith
IPC分类号: H01R13/33
CPC分类号: H01L31/0508 , F16B5/0635 , F16B2001/0064 , F24S25/67 , Y02E10/50
摘要: A connector assembly is provided for connecting, two planar surfaces or structures together to permit electrical transmission between the two. As described, the connector have at least two housing sections having grooves formed therein for receiving springs, such as canted coil springs. The springs are configured to provide constant mechanical and electrical connection between multiple parts and allow for small motions between such parts. By allowing for movement of the connected parts, adequate connection during thermal changes and/or vibrations is maintained. This is possible due to the spring contact interface between the connector assembly and the connecting parts, which allows relative movement between the springs and the connecting parts.
摘要翻译: 提供连接器组件用于将两个平面表面或结构连接在一起以允许两者之间的电传输。 如上所述,连接器具有至少两个壳体部分,其中形成有用于接收弹簧的槽,例如倾斜螺旋弹簧。 弹簧构造成在多个部件之间提供恒定的机械和电气连接,并允许这些部件之间的小运动。 通过允许连接部件的移动,保持在热变化和/或振动期间的充分连接。 这是可能的,因为连接器组件和连接部件之间的弹簧接触界面,这允许弹簧和连接部件之间的相对移动。
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公开(公告)号:US09546173B2
公开(公告)日:2017-01-17
申请号:US14428546
申请日:2013-09-17
申请人: Michael Patrick Dillon , Mika Lindvall , Daniel Poon , Savithri Ramurthy , Vivek Rauniyar , Cynthia Shafer , Sharadha Subramanian , Huw Rowland Tanner
发明人: Michael Patrick Dillon , Mika Lindvall , Daniel Poon , Savithri Ramurthy , Vivek Rauniyar , Cynthia Shafer , Sharadha Subramanian , Huw Rowland Tanner
IPC分类号: A61K31/519 , C07D239/70 , C07D487/04 , C07D207/36 , A61K31/527 , A61K45/06 , C07D487/10
CPC分类号: C07D487/04 , A61K31/519 , A61K31/527 , A61K45/06 , C07D207/36 , C07D487/10
摘要: The present invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof; as further described herein. The present invention further provides pharmaceutical compositions comprising these compounds, and combinations comprising these compounds combined with or used with a therapeutic co-agent, as well as therapeutic uses of these compounds and compositions. These are useful in the treatment of diseases such as cancer that are associated with activation of ERK1 and/or ERK2, and especially for MAPK pathway dependent cancers showing resistance to Raf and/or MEK inhibitory cancer therapeutics.
摘要翻译: 本发明提供式(I)的化合物及其药学上可接受的盐; 如本文进一步描述的。 本发明还提供包含这些化合物的药物组合物,以及包含与治疗性助剂组合或与其一起使用的这些化合物的组合,以及这些化合物和组合物的治疗用途。 这些可用于治疗与ERK1和/或ERK2的激活相关的疾病,特别是对显示出对Raf和/或MEK抑制性癌症治疗剂的抗性的MAPK通路依赖性癌症的疾病的治疗
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公开(公告)号:USD749555S1
公开(公告)日:2016-02-16
申请号:US29477073
申请日:2013-12-19
申请人: Daniel Poon , Evan Andrew Reese
设计人: Daniel Poon , Evan Andrew Reese
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公开(公告)号:US20150274733A1
公开(公告)日:2015-10-01
申请号:US14428546
申请日:2013-09-17
申请人: Michael Patrick DILLON , Mika LINDVALL , Daniel POON , Savithri RAMURTHY , Vivek RAUNIYAR , Cynthia SHAFER , Sharadha SUBRAMANIAN , Huw TANNER
发明人: Michael Patrick Dillon , Mika Lindvall , Daniel Poon , Savithri Ramurthy , Vivek Rauniyar , Cynthia Shafer , Sharadha Subramanian , Huw Rowland Tanner
IPC分类号: C07D487/04 , A61K45/06 , A61K31/527 , A61K31/519 , C07D487/10
CPC分类号: C07D487/04 , A61K31/519 , A61K31/527 , A61K45/06 , C07D207/36 , C07D487/10
摘要: The present invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof; as further described herein. The present invention further provides pharmaceutical compositions comprising these compounds, and combinations comprising these compounds combined with or used with a therapeutic co-agent, as well as therapeutic uses of these compounds and compositions. These are useful in the treatment of diseases such as cancer that are associated with activation of ERK1 and/or ERK2, and especially for MAPK pathway dependent cancers showing resistance to Raf and/or MEK inhibitory cancer therapeutics
摘要翻译: 本发明提供式(I)的化合物及其药学上可接受的盐; 如本文进一步描述的。 本发明还提供包含这些化合物的药物组合物,以及包含与治疗性助剂组合或与其一起使用的这些化合物的组合,以及这些化合物和组合物的治疗用途。 这些可用于治疗与ERK1和/或ERK2的激活相关的疾病,特别是对显示出对Raf和/或MEK抑制性癌症治疗剂的抗性的MAPK通路依赖性癌症的疾病的治疗
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公开(公告)号:US08501758B2
公开(公告)日:2013-08-06
申请号:US12870130
申请日:2010-08-27
申请人: Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
发明人: Shenlin Huang , Xianming Jin , Zuosheng Liu , Daniel Poon , John Tellew , Yongqin Wan , Xing Wang , Yongping Xie
IPC分类号: A01N43/54
CPC分类号: C07D403/04 , A61K9/0053 , A61K31/4184 , A61K31/506 , A61K45/06 , C07D401/14 , C07D405/14 , A61K2300/00
摘要: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
摘要翻译: 本发明提供了一类新颖的化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法,特别是涉及B-Raf异常激活的疾病或病症。
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36.
公开(公告)号:US06835084B2
公开(公告)日:2004-12-28
申请号:US10366912
申请日:2003-02-14
申请人: Daniel Poon , Peter J. Balsells
发明人: Daniel Poon , Peter J. Balsells
IPC分类号: H01R13627
CPC分类号: H01R13/187 , H01R13/111 , H01R13/623 , H01R2201/12
摘要: A medically implantable electrical connector includes a housing having a bore with an internal V-groove or a flat bottom groove therein along with radial garter spring disposed in the V-groove or an axial garter spring disposed in the flat bottom groove. A pin is provided and sized for insertion in the housing bore. The housing, spring and pin are formed from a combination of medically implantable materials in order to control electrical resistivity between the housing, the garter spring and the pin.
摘要翻译: 医学上可植入的电连接器包括壳体,该壳体具有内部V形槽或其中的平坦底部凹槽以及布置在V形槽中的径向卡定弹簧或设置在平坦底部凹槽中的轴向弹簧弹簧。 一个销被提供并且尺寸适于插入壳体孔中。 壳体,弹簧和销由医疗可植入材料的组合形成,以便控制壳体,套环弹簧和销之间的电阻率。
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公开(公告)号:USD776098S1
公开(公告)日:2017-01-10
申请号:US29498106
申请日:2014-07-31
申请人: Daniel Poon
设计人: Daniel Poon
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公开(公告)号:US20150264822A1
公开(公告)日:2015-09-17
申请号:US14210448
申请日:2014-03-14
申请人: Daniel Poon
发明人: Daniel Poon
CPC分类号: A45C11/00 , A45C2011/002
摘要: A protective case for a portable device having a touch screen is constructed from a back frame, a front frame and a stretchable cover. The back frame receives the portable device through an open front and the stretchable cover is stretched over the back frame and the device. A portion of the cover stretches over the back frame and portable device such that the portable device is securely held in the back frame and the touch screen can be accessed and used when the device is mounted in the back frame and stretchable cover. A front frame with a transparent screen protector that allows the touch screen of the portable device to be used while the device is fully enclosed in the case is removably coupled to the back frame with grasping arms that connect to mounting portions on the back frame that extend through openings in the stretchable cover. A debris resistant seal is created between the front frame and the stretchable cover through a compression fit.
摘要翻译: 具有触摸屏的便携式设备的保护壳由后框架,前框架和可拉伸盖构成。 后框架通过开放的前部接收便携式设备,并且可拉伸的盖子在后框架和设备上被拉伸。 盖的一部分在后框架和便携式装置上延伸,使得便携式装置被牢固地保持在后框架中,并且当装置安装在后框架和可拉伸盖中时可以访问和使用触摸屏。 具有透明屏幕保护器的前框架允许便携式设备的触摸屏在设备完全封闭在壳体中时被使用,可拆卸地联接到后框架,该抓握臂连接到延伸的后框架上的安装部分 通过可伸缩盖中的开口。 通过压缩配合在前框架和可拉伸盖之间产生无碎屑的密封。
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公开(公告)号:US08096842B2
公开(公告)日:2012-01-17
申请号:US12787602
申请日:2010-05-26
申请人: Daniel Poon , Kyle Smith
发明人: Daniel Poon , Kyle Smith
IPC分类号: H01R13/33
CPC分类号: H01L31/0508 , F16B5/0635 , F16B2001/0064 , F24S25/67 , Y02E10/50
摘要: A connector assembly is provided for connecting two planar surfaces or structures together to permit electrical transmission between the two. As described, the connector have at least two housing sections having grooves formed therein for receiving springs, such as canted coil springs. The springs are configured to provide constant mechanical and electrical connection between multiple parts and allow for small motions between such parts. By allowing for movement of the connected parts, adequate connection during thermal changes and/or vibrations is maintained. This is possible due to the spring contact interface between the connector assembly and the connecting parts, which allows relative movement between the springs and the connecting parts.
摘要翻译: 提供连接器组件用于将两个平面表面或结构连接在一起以允许两者之间的电传输。 如上所述,连接器具有至少两个壳体部分,其中形成有用于接收弹簧的槽,例如倾斜螺旋弹簧。 弹簧构造成在多个部件之间提供恒定的机械和电气连接,并允许这些部件之间的小运动。 通过允许连接部件的移动,保持在热变化和/或振动期间的充分连接。 这是可能的,因为连接器组件和连接部件之间的弹簧接触界面,这允许弹簧和连接部件之间的相对移动。
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