公开(公告)号：US06348328B1

公开(公告)日：2002-02-19

申请号：US08858207

申请日：1997-05-14

申请人： Michael Terence Black ,  John Edward Hodgson ,  David Justin Charles Knowles ,  Richard Oakley Nicholas ,  Robert King Stodola

发明人： Michael Terence Black ,  John Edward Hodgson ,  David Justin Charles Knowles ,  Richard Oakley Nicholas ,  Robert King Stodola

IPC分类号： C12P2102

CPC分类号： C07K14/3156 ,  C07K2319/00

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

摘要翻译： 本发明涉及新鉴定的多核苷酸，由这些多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这些多核苷酸和多肽的产生以及用多核苷酸转化的重组宿主细胞。 本发明还涉及抑制这些多核苷酸或多肽的生物合成或作用以及这种抑制剂在治疗中的用途。

公开(公告)号：US5869290A

公开(公告)日：1999-02-09

申请号：US752132

申请日：1996-11-21

申请人： Kathryn Belinda Freeman ,  Richard Oakley Nicholas ,  George Pietro Livi

发明人： Kathryn Belinda Freeman ,  Richard Oakley Nicholas ,  George Pietro Livi

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P31/04 ,  C07K14/395 ,  C07K14/40 ,  C07K16/14 ,  C12N5/10 ,  C12N15/09 ,  C12N15/31 ,  C12Q1/68 ,  C12N15/00 ,  C07K14/00

CPC分类号： C07K14/40 ,  A61K38/00 ,  A61K48/00 ,  Y10S530/824

摘要： The invention provides caYAE1 polypeptides and DNA (RNA) encoding such caYAE1 and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such caYAE1 for the treatment of infection, particularly fungal infections. Antagonists against such caYAE1 and their use as a therapeutic to treat infections, particularly fungal infections are also provided. Further provided are diagnostic assays for detecting diseases related to the presence of caYAE1 nucleic acid sequences and the polypeptides in a host. Also provided are diagnostic assays for detecting polynucleotides encoding caYAE1 and for detecting the polypeptide in a host.

摘要翻译： 本发明提供了编码这种caYAE1的caYAE1多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还提供了利用这种caYAE1治疗感染，特别是真菌感染的方法。 还提供了抗这种caYAE1的拮抗剂及其用作治疗感染特别是真菌感染的治疗剂。 还提供了用于检测与宿主中caYAE1核酸序列和多肽的存在相关的疾病的诊断测定。 还提供了用于检测编码caYAE1的多核苷酸并用于检测宿主中的多肽的诊断测定。