Patent search ap:("Mirati Therapeutics Page Inc." OR "Array BioPharma Inc.") AND inv:"Adam Cook"

31.

发明申请
2-ARYL- AND 2-HETEROARYL-SUBSTITUTED 2-PYRIDAZIN-3(2H)-ONE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES 审中-公开

公开(公告)号：US20170260168A1

公开(公告)日：2017-09-14

申请号：US15333148

申请日：2016-10-24

Applicant: Array BioPharma, Inc.

Inventor： Steven W. Andrews , James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Andrew T. Metcalf , David Moreno , Li Ren , Tony P. Tang

IPC: C07D403/14 , A61K31/501 , G01N33/574 , A61K31/5377 , C07D401/14 , C12Q1/68 , A61K45/06 , C07D413/14

CPC classification number: C07D403/14 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D401/14 , C07D413/14 , C12Q1/6886 , G01N33/574

Abstract: Provided herein are compounds of the general Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which X, R1, R2, R3, Ring A and z have the meanings given in the specification, which are inhibitors of FGFR1, FGFR2, FGFR3 and/or FGFR4 and are useful in the treatment and prevention of diseases which can be treated with an FGFR inhibitor, including diseases or disorders mediated by FGFR1, FGFR2, FGFR3 and/or FGFR4.

32.

发明授权
Serine/threonine kinase inhibitors 有权

公开(公告)号：US09670208B2

公开(公告)日：2017-06-06

申请号：US15197445

申请日：2016-06-29

Applicant: Array BioPharma Inc. , Genentech, Inc.

Inventor： James F. Blake , Adam Cook , John Gaudino , Indrani W. Gunawardana , Erik James Hicken , Kevin W. Hunt , Michael Lyon , Andrew T. Metcalf , Peter J. Mohr , David A. Moreno , Brad Newhouse , Li Ren , Jacob Schwarz , Huifen Chen , Lewis Gazzard , Jane Schmidt , Steve Do

IPC: C07D471/04 , A61K45/06 , A61K31/5377 , A61K31/506 , A61K31/444 , C07D487/04 , C07D519/00 , A61K31/55

CPC classification number: C07D471/04 , A61K31/444 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D487/04 , C07D519/00

Abstract: Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.

33.

发明授权
6-substituted phenoxychroman carboxylic acid derivatives 有权
Title translation: 6-取代的苯氧基苯并二氢吡喃羧酸衍生物

公开(公告)号：US08716498B2

公开(公告)日：2014-05-06

申请号：US14013898

申请日：2013-08-29

Applicant: Array BioPharma Inc.

Inventor： Laurence E. Burgess , Christopher T. Clark , Adam Cook , Christopher P. Corrette , Robert Kirk DeLisle , George A. Doherty , Kevin W. Hunt , Todd T. Romoff , Ganghyeok Kim

IPC: C07D311/58

CPC classification number: C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12

Abstract: A compound having the formula: is useful in the preparation of compounds of Formula I.

Abstract translation: 具有下式的化合物可用于制备式I化合物。

34.

发明申请
6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES 有权
Title translation: 6-取代的苯氧基羧酸衍生物

公开(公告)号：US20140005418A1

公开(公告)日：2014-01-02

申请号：US14013898

申请日：2013-08-29

Applicant: ARRAY BIOPHARMA INC.

Inventor： Laurence E. Burgess , Christopher T. Clark , Adam Cook , Christopher P. Corrette , Robert Kirk DeLisle , George A. Doherty , Kevin W. Hunt , Todd T. Romoff , Ganghyeok Kim

IPC: C07D311/58

CPC classification number: C07D311/58 , C07D311/04 , C07D405/12 , C07D407/12

Abstract: A compound having the formula: is useful in the preparation of compounds of Formula I.

Abstract translation: 具有下式的化合物可用于制备式I化合物。

35.

发明授权
Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors 有权

公开(公告)号：US11998545B2

公开(公告)日：2024-06-04

申请号：US18342314

申请日：2023-06-27

Applicant: Array BioPharma, Inc.

Inventor： Steven W. Andrews , Sean Aronow , James F. Blake , Barbara J. Brandhuber , Adam Cook , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Elizabeth A. McFaddin , Megan L. McKenney , Oren T. McNulty , Andrew T. Metcalf , David A. Moreno , Tony P. Tang , Li Ren

IPC: C07D401/02 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/4985 , A61K31/4995 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , A61P1/12 , A61P35/00 , A61P35/02 , A61P35/04 , C07D401/10 , C07D471/04 , C07D519/00

CPC classification number: A61K31/496 , A61K31/444 , A61K31/4985 , A61K31/4995 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K45/06 , A61P1/12 , A61P35/00 , A61P35/02 , A61P35/04 , C07D471/04 , C07D519/00

Abstract: Provided herein are compounds of the Formula I:

and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

36.

发明授权
Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases 有权

公开(公告)号：US11780835B2

公开(公告)日：2023-10-10

申请号：US17376571

申请日：2021-07-15

Applicant: Array BioPharma Inc.

Inventor： Ronald Jay Hinklin , Shelley Allen , Patrick Barbour , Adam Cook , Joshua Dahlke , John Gaudino , Ellen Laird , Oren T. McNulty , Qian Zhao

IPC: C07D471/04

CPC classification number: C07D471/04

Abstract: Provided herein are compounds of the Formula (I): and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R1, R2, R9, X1 and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.

37.

发明授权
Bicyclic fused pyridine compounds as inhibitors of TAM kinases 有权

公开(公告)号：US11247990B1

公开(公告)日：2022-02-15

申请号：US16893784

申请日：2018-12-05

Applicant: ARRAY BIOPHARMA INC.

Inventor： Shelley Allen , Mark Laurence Boys , Adam Cook , John Gaudino , Ronald Jay Hinklin , Ellen Laird , Oren T. McNulty , Andrew T. Metcalf , Brad Newhouse , John E. Robinson

IPC: C07D471/04 , C07D519/00

Abstract: Provided herein are compounds of the Formula (I): and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein Ring A, X1, X2, X3, R1, R2 and R3 are as defined herein, which are inhibitors of one or more TAM kinases and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor.

38.

发明申请
SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS 有权

公开(公告)号：US20210186959A1

公开(公告)日：2021-06-24

申请号：US17165168

申请日：2021-02-02

Applicant: Array BioPharma, Inc.

Inventor： Steven W. Andrews , Sean Aronow , James F. Blake , Barbara J. Brandhuber , Adam Cook , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Elizabeth A. McFaddin , Megan L. McKenney , Oren T. McNulty , Andrew T. Metcalf , David A. Moreno , Tony P. Tang , Li Ren

IPC: A61K31/496 , A61K31/506 , A61K31/4995 , C07D519/00 , A61P35/00 , A61K31/5377 , A61P1/12 , A61P35/04 , A61P35/02 , A61K31/4985 , C07D471/04 , A61K45/06 , A61K31/551 , A61K31/444

Abstract: Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.