公开(公告)号：US08447399B2

公开(公告)日：2013-05-21

申请号：US12060334

申请日：2008-04-01

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N1/00

CPC分类号： A61N1/368 ,  A61N1/0587 ,  A61N1/3627 ,  A61N1/3684

摘要： A system and method for managing and inhibiting cardiac remodeling in MI patients. Bi-ventricular stimulation is constantly provided with and without sensing to encourage normal pumping of the heart on a consistent basis. Pulses are administered using an anodal pulse followed by a cathodal pulse to stimulate cardiac muscle contraction. Stem cells are administered to MI areas to encourage regeneration of cardiac tissue in the damaged area. Stimulation may be provided to both healthy and compromised cardiac tissue.

摘要翻译： 一种用于管理和抑制MI患者心脏重塑的系统和方法。 不间断地提供双心室刺激，有助于不受感染，以鼓励心脏正常泵送。 使用阳极脉冲随后阴极脉冲施用脉冲以刺激心肌收缩。 将干细胞施用于MI区域以促进损伤区域中心脏组织的再生。 刺激可以提供给健康和妥协的心脏组织。

公开(公告)号：US07908003B1

公开(公告)日：2011-03-15

申请号：US11763768

申请日：2007-06-15

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N1/00

CPC分类号： A61N1/3627 ,  A61B5/0452 ,  A61N1/365 ,  A61N1/36557

摘要： A system and method for treating ischemic heart disease by increasing heart efficiency. By application of an anodal pulse at or above threshold, the efficiency of the heart is improved by increasing the resting membrane potential of the myocardial cells, increasing the size of the anodal virtual stimulatory electrode, or reducing the ventricular stretching during filling of the ventricle.

摘要翻译： 一种通过增加心脏功能来治疗缺血性心脏病的系统和方法。 通过施加等于或高于阈值的阳极脉冲，通过增加心肌细胞的静息膜电位，增加阳极虚拟刺激电极的尺寸或减少在心室填充期间的心室伸展来改善心脏的效率。

公开(公告)号：US06895274B2

公开(公告)日：2005-05-17

申请号：US09929478

申请日：2001-08-14

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N1/36 ,  A61N1/362 ,  A61N1/365 ,  A61N1/368 ,  A61N1/37 ,  A61N1/39

CPC分类号： A61N1/368 ,  A61N1/3622 ,  A61N1/36514 ,  A61N1/3712 ,  A61N1/3962

摘要： Protocols for antitachycardial pacing including biphasic stimulation administered at, or just above, the diastolic depolarization threshold potential; biphasic or conventional stimulation initiated at, or just above, the diastolic depolarization threshold potential, reduced, upon capture, to below threshold; and biphasic or conventional stimulation administered at a level set just below the diastolic depolarization threshold potential. These protocols result in reliable cardiac capture with a lower stimulation level, thereby causing less damage to the heart, extending battery life, causing less pain to the patient and having greater therapeutic effectiveness. In those protocols using biphasic cardiac pacing, a first and second stimulation phase is administered. The first stimulation phase has a predefined polarity, amplitude and duration. The second stimulation phase also has a predefined polarity, amplitude and duration. The two phases are applied sequentially. Contrary to current thought, anodal stimulation is first applied and followed by cathodal stimulation. In this fashion, pulse conduction through the cardiac muscle is improved together with the increase in contractility.

摘要翻译： 用于抗心动过速起搏的方案，包括在舒张期去极化阈值电位施用或恰好高于舒张去极化阈值电位的双相刺激; 在舒张去极化阈值电位或之前开始的双相或常规刺激，在捕获时降低到阈值以下; 以及在恰好低于舒张期去极化阈值电位的水平下施用的双相或常规刺激。 这些协议导致可靠的心脏捕获，具有较低的刺激水平，从而对心脏造成较小的损伤，延长电池寿命，对患者造成更少的疼痛并具有更大的治疗效果。 在使用双相心脏起搏的那些方案中，施用第一和第二刺激阶段。 第一刺激阶段具有预定义的极性，幅度和持续时间。 第二刺激阶段也具有预定义的极性，幅度和持续时间。 顺序应用两个阶段。 与目前的想法相反，首先应用阳极刺激，然后进行阴极刺激。 以这种方式，通过心肌的脉冲传导随着收缩性的增加而提高。

公开(公告)号：US06337995B1

公开(公告)日：2002-01-08

申请号：US09711030

申请日：2000-11-13

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N139

CPC分类号： A61N1/3712 ,  A61N1/36146 ,  A61N1/3622 ,  A61N1/3706 ,  A61N1/395 ,  A61N1/3956

摘要： Atrial sensing and stimulation as intervention for atrial fibrillation. The present invention relates to a method of atrial defibrillation using an implanted electronic stimulator. In a variety of protocols varying combinations of conventional and biphasic stimulation are applied at threshold and sub-threshold levels. In a preferred embodiment, the implantable electronic stimulator of the present invention includes multiple electrodes having stimulating and sensing capabilities. The small size of these electrodes allows for intravenous insertion into the patient.

摘要翻译： 心房感应和刺激作为房颤的干预。 本发明涉及使用植入电子刺激器的心房除颤方法。 在各种协议中，在阈值和次阈值水平上应用常规和双相刺激的不同组合。 在优选实施例中，本发明的可植入电子刺激器包括具有刺激和感测能力的多个电极。 这些电极的小尺寸允许静脉插入患者体内。

公开(公告)号：US6067470A

公开(公告)日：2000-05-23

申请号：US35455

申请日：1998-03-05

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N1/368 ,  A61N1/362 ,  A61N1/39

CPC分类号： A61N1/3622

摘要： An anti-reentry apparatus and method for reverting ventricular arrhythmias. Biphasic stimulation is applied at multiple ventricular sites to revert arrhythmias caused by reentry, particularly multiple random reentry. In the preferred embodiment, the first phase of biphasic stimulation is anodal, and is at a maximum subthreshold amplitude. The anodal phase preconditions the myocardium to accept the second phase (cathodal) such that less electrical energy is required to reach the threshold amplitude to produce depolarization. The anodal phase stimulation may have a shape over time that is square wave, ramped, or a series of short square wave pulses. Multiple electrodes located at multiple ventricular sites may be stimulated simultaneously, or they may be sequentially stimulated over time in a manner mimicking the normal progress pattern of cardiac depolarization. The multiple ventricular electrodes may stimulate from internal or external surfaces. One or both ventricles may receive biphasic stimulation from multiple electrodes. The invention also may be practiced with respect to atria.

摘要翻译： 一种用于恢复室性心律失常的反折返装置和方法。 双相刺激应用于多个心室部位以恢复由折返引起的心律失常，特别是多次随机折返。 在优选实施例中，双相刺激的第一阶段为阳极，并处于最大亚阈值幅度。 阳极相预处理心肌以接受第二相（阴极），使得需要更少的电能达到阈值振幅以产生去极化。 阳极相刺激可以具有随时间变化的形状，即方波，斜坡或一系列短方波脉冲。 可以同时刺激位于多个心室部位的多个电极，或者可以以模仿心脏去极化的正常进展模式的方式随时间推移它们。 多个心室电极可以从内部或外部表面刺激。 一个或两个脑室可以接收来自多个电极的双相刺激。 本发明也可以相对于心房来实施。

公开(公告)号：US5476497A

公开(公告)日：1995-12-19

申请号：US290113

申请日：1994-08-15

申请人： Morton M. Mower ,  Seah Nisam

发明人： Morton M. Mower ,  Seah Nisam

IPC分类号： A61N1/05

CPC分类号： A61N1/05 ,  A61N1/056

摘要： To prevent electrical conductors which connect a patient-implanted high energy electrode to a pulse generator from short circuiting at locations where a tubular lead body in which the conductors are contained encounters a sharp bend, the lead body has an oval cross section and the conductors are disposed on the major axis of the oval. This arrangement promotes preferential bending of the lead body about the major axis, rather than the minor axis of the oval body, tending to maintain the spacing between the conductors and thereby minimizing short circuits. The lead body can be resiliently compressed, however, for insertion into a patient in a cylindrical catheter of circular cross section.

摘要翻译： 为了防止将患者植入的高能电极连接到脉冲发生器的电导体在其中包含导体的管状引线体的位置处发生短路，遇到尖锐的弯曲，引线体具有椭圆形横截面，导体为 设置在椭圆的长轴上。 这种布置促进引线体围绕长轴的优先弯曲，而不是椭圆体的短轴，倾向于保持导体之间的间隔，从而使短路最小化。 然而，引线体可以弹性压缩，以便在圆形横截面的圆柱形导管中插入患者体内。

公开(公告)号：US5346506A

公开(公告)日：1994-09-13

申请号：US974049

申请日：1992-11-10

申请人： Morton M. Mower ,  Peng S. Chen

发明人： Morton M. Mower ,  Peng S. Chen

IPC分类号： A61N1/38 ,  A61N1/39

CPC分类号： A61N1/385 ,  A61N1/3943

摘要： A method of determining a defibrillation threshold for an implantable cardiac defibrillator, based upon determining the 50% probability of reaching the upper limit of vulnerability. The 50% probability of reaching the upper limit of vulnerability at the mid-upslope of the T-wave is found to closely approximate the 50% probability of successful defibrillation used to set the shock energy level of the defibrillator. A delayed up-down algorithm is used to determine the shock strength associated with 50% probability of reaching the upper limit of vulnerability.

摘要翻译： 基于确定达到脆弱性上限的50％的概率来确定可植入心脏除颤器的除颤阈值的方法。 发现在T波中上游达到脆弱性上限的50％概率接近用于设定除颤器的冲击能量水平的成功除颤的50％概率。 使用延迟上调算法来确定与达到脆弱性上限的50％概率相关的冲击强度。

公开(公告)号：US5111815A

公开(公告)日：1992-05-12

申请号：US597378

申请日：1990-10-15

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N1/365 ,  A61N1/39

CPC分类号： A61N1/36514

摘要： A method and apparatus for cardioverter/pacemaking utilizing neurosensing. The invention utilizes the baroreceptor nerves found in the body. A neurosense electrode is placed around the carotid sinus nerve and a sense amplifier with automatic gain control and an integral band pass filter provides a frequency-to-voltage converter with a frequency proportional to the stimulus received from the carotid sinus nerve. The voltage from the frequency-to-voltage converter is sent to the analog-to-digital converter where it is bussed to a microprocessor. The microprocessor then drives a pacing lead and in the presence of a cardiac signal the microprocessor provides a cardioverting signal to the cardioverting lead if ventricular arrhythmia is sensed. The microprocessor also drives a telemetry coil and receives ventricular information from the ventricular sensing lead.

公开(公告)号：US4928688A

公开(公告)日：1990-05-29

申请号：US299895

申请日：1989-01-23

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N1/362 ,  A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/3684

摘要： A method of treating hemodynamic disfunction by simultaneously pacing both ventricles of a heart. At least one ECG amplifier is arranged to separately detect contraction of each ventricle and a stimulator is then activated for issuing stimulating pulses to both ventricles in a manner to assure simultaneous contraction of both ventricles, thereby to assure hemodynamic efficiency. A first ventricle is stimulated simultaneously with contraction of a second ventricle when the first fails to properly contract. Further, both ventricles are stimulated after lapse of a predetermined A-V escape interval. One of a pair of electrodes, connected in series, is placed through the superior vena cava into the right ventricle and a second is placed in the coronary sinus about the left ventricle. Each electrode performs both pacing and sensing functions. The pacer is particularly suitable for treating bundle branch blocks or slow conduction in a portion of the ventricles.

摘要翻译： 通过同时起搏心脏的两个心室来治疗血液动力学障碍的方法。 至少一个ECG放大器被设置为分别检测每个心室的收缩，然后激活刺激器以便以两种心室的刺激脉冲发出刺激脉冲，以确保两个脑室同时收缩，从而确保血液动力学效率。 当第一个心室不能正常收缩时，第一个心室与第二个心室的收缩同时受到刺激。 此外，在经过预定的A-V逃逸间隔之后刺激两个心室。 串联连接的一对电极之一通过上腔静脉置入右心室，另一个电极放置在左心室周围的冠状窦内。 每个电极执行起搏和感应功能。 该起搏器特别适用于治疗束支传导阻滞或在一部分心室中缓慢传导。

公开(公告)号：US09789303B2

公开(公告)日：2017-10-17

申请号：US14970029

申请日：2015-12-15

申请人： Morton M. Mower

发明人： Morton M. Mower

IPC分类号： A61N1/04 ,  A61N1/32 ,  A61K9/00 ,  A61K9/70

CPC分类号： A61N1/0468 ,  A61F13/02 ,  A61K9/0009 ,  A61K9/703 ,  A61K31/635 ,  A61K33/26 ,  A61K33/30 ,  A61N1/0496 ,  A61N1/326

摘要： A pad for electrically stimulated wound healing, including a pad configured to be placed on a wound, at least one anode disposed on the pad to contact the wound, and at least one cathode disposed on the pad to contact the wound, the at least one cathode being disposed separately from the at least on anode. The pad wherein the at least one anode and the at least one cathode in contact with the wound provide a flow of electrical current in an intended direction through the wound based on the separate locations of the at least one anode and the at least one cathode.